Cargando…

Characterizations of Hamster Retina as a Model for Studies of Retinal Cholesterol Homeostasis

SIMPLE SUMMARY: This work represents a comprehensive evaluation of hamster retina by state-of-the-art methodologies and provides evidence that hamsters may represent a better model for studies of retinal cholesterol maintenance than mice. The latter is an important finding, as disturbances in retina...

Descripción completa

Detalles Bibliográficos
Autores principales:	El-Darzi, Nicole, Mast, Natalia, Dailey, Brian, Denker, John, Li, Yong, Vance, Joseph, Pikuleva, Irina A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533155/ https://www.ncbi.nlm.nih.gov/pubmed/34681102 http://dx.doi.org/10.3390/biology10101003

Ejemplares similares

Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters
por: Mast, Natalia, et al.
Publicado: (2023)

The Interplay between Retinal Pathways of Cholesterol Output and Its Effects on Mouse Retina
por: Petrov, Alexey M., et al.
Publicado: (2019)

N,N-Dimethyl-3β-hydroxycholenamide Reduces Retinal Cholesterol via Partial Inhibition of Retinal Cholesterol Biosynthesis Rather Than its Liver X Receptor Transcriptional Activity
por: El-Darzi, Nicole, et al.
Publicado: (2018)

The normalizing effects of the CYP46A1 activator efavirenz on retinal sterol levels and risk factors for glaucoma in Apoj(−/−) mice
por: El-Darzi, Nicole, et al.
Publicado: (2023)

Low-Dose Anti-HIV Drug Efavirenz Mitigates Retinal Vascular Lesions in a Mouse Model of Alzheimer’s Disease
por: El-Darzi, Nicole, et al.
Publicado: (2022)

2-Hydroxypropyl-β-cyclodextrin mitigates pathological changes in a mouse model of retinal cholesterol dyshomeostasis
por: El-Darzi, Nicole, et al.
Publicado: (2022)

Spatial Distribution of the Pathways of Cholesterol Homeostasis in Human Retina
por: Zheng, Wenchao, et al.
Publicado: (2012)

CYP46A1-dependent and independent effects of efavirenz treatment
por: Mast, Natalia, et al.
Publicado: (2020)

Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain
por: Saeed, Ahmed A., et al.
Publicado: (2014)

Brain sterol flux mediated by cytochrome P450 46A1 affects membrane properties and membrane-dependent processes
por: Petrov, Alexey M, et al.
Publicado: (2020)

Quantification of Histone Deacetylase Isoforms in Human Frontal Cortex, Human Retina, and Mouse Brain
por: Anderson, Kyle W., et al.
Publicado: (2015)

Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1)
por: Mast, Natalia, et al.
Publicado: (2017)

Cholesterol homeostasis in the vertebrate retina: biology and pathobiology
por: Ramachandra Rao, Sriganesh, et al.
Publicado: (2021)

Cholesterol crystal formation is a unifying pathogenic mechanism in the development of diabetic retinopathy
por: Hammer, Sandra S., et al.
Publicado: (2023)

Increased Acetylcholine Levels and Other Brain Effects in 5XFAD Mice after Treatment with 8,14-Dihydroxy Metabolite of Efavirenz
por: Mast, Natalia, et al.
Publicado: (2022)

CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer’s disease
por: Lerner, Alan J., et al.
Publicado: (2022)

Editorial: Cholesterol and Neurodegenerative Diseases - Pressing Questions and How to Address Them
por: Betuing, Sandrine, et al.
Publicado: (2022)

Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications
por: Pikuleva, Irina A., et al.
Publicado: (2021)

Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism
por: Yutuc, Eylan, et al.
Publicado: (2020)

Histone H3 Ser57 and Thr58 phosphorylation in the brain of 5XFAD mice
por: Anderson, Kyle W., et al.
Publicado: (2015)

Brain Acetyl-CoA Production and Phosphorylation of Cytoskeletal Proteins Are Targets of CYP46A1 Activity Modulation and Altered Sterol Flux
por: Mast, Natalia, et al.
Publicado: (2021)

Inhibition of pancreatic cholesterol esterase reduces cholesterol absorption in the hamster
por: Heidrich, John E, et al.
Publicado: (2004)

In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds
por: Mast, Natalia, et al.
Publicado: (2019)

Visual arrestin modulates gene expression in the retinal pigment epithelium: Implications for homeostasis in the retina
por: Nagaoka, Natsuko, et al.
Publicado: (2019)

Retinal homeostasis and metformin-induced protection are not affected by retina-specific Pparδ knockout
por: Xu, Lei, et al.
Publicado: (2020)

ATP and Adenosine in the Retina and Retinal Diseases
por: Ye, Shan-Shan, et al.
Publicado: (2021)

Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1
por: White, Mark Andrew, et al.
Publicado: (2008)

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis
por: Das, Akash, et al.
Publicado: (2014)

Curcumin Supplementation Ameliorates Bile Cholesterol Supersaturation in Hamsters by Modulating Gut Microbiota and Cholesterol Absorption
por: Hong, Ting, et al.
Publicado: (2022)

Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration
por: Liang, Ning, et al.
Publicado: (2021)

Retinal Oxygenation in Inherited Diseases of the Retina
por: Türksever, Cengiz, et al.
Publicado: (2021)

Isolation and characterization of Chinese hamster ovary cell mutants defective in intracellular low density lipoprotein-cholesterol trafficking
Publicado: (1990)

Epigenetic regulation of cholesterol homeostasis
por: Meaney, Steve
Publicado: (2014)

Cholesterol metabolism and homeostasis in the brain
por: Zhang, Juan, et al.
Publicado: (2015)

SUMOylation in the control of cholesterol homeostasis
por: Talamillo, Ana, et al.
Publicado: (2020)

Monocyte infiltration and proliferation reestablish myeloid cell homeostasis in the mouse retina following retinal pigment epithelial cell injury
por: Ma, Wenxin, et al.
Publicado: (2017)

From Dietary Cholesterol to Blood Cholesterol, Physiological Lipid Fluxes, and Cholesterol Homeostasis
por: Stellaard, Frans
Publicado: (2022)

A tale of 2 gasses, 1 regulator, and cholesterol homeostasis
por: Fenton, Nicole M., et al.
Publicado: (2023)

Deletion of TSPO Causes Dysregulation of Cholesterol Metabolism in Mouse Retina
por: Farhan, Fahad, et al.
Publicado: (2021)

Changes in cholesterol homeostasis modify the response of F1B hamsters to dietary very long chain n-3 and n-6 polyunsaturated fatty acids
por: Lecker, Jaime L, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_7ba6u4vn6on1b7einli3bccf3g