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Targeting Drug Chemo-Resistance in Cancer Using Natural Products
Cancer is one of the leading causes of death globally. The development of drug resistance is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms to reduce the therapeutic effects of anticancer drugs, thereby causing chemotherapy failure. Natural products are ac...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533186/ https://www.ncbi.nlm.nih.gov/pubmed/34680470 http://dx.doi.org/10.3390/biomedicines9101353 |
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author | Talib, Wamidh H. Alsayed, Ahmad Riyad Barakat, Muna Abu-Taha, May Ibrahim Mahmod, Asma Ismail |
author_facet | Talib, Wamidh H. Alsayed, Ahmad Riyad Barakat, Muna Abu-Taha, May Ibrahim Mahmod, Asma Ismail |
author_sort | Talib, Wamidh H. |
collection | PubMed |
description | Cancer is one of the leading causes of death globally. The development of drug resistance is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms to reduce the therapeutic effects of anticancer drugs, thereby causing chemotherapy failure. Natural products are accessible, inexpensive, and less toxic sources of chemotherapeutic agents. Additionally, they have multiple mechanisms of action to inhibit various targets involved in the development of drug resistance. In this review, we have summarized the basic research and clinical applications of natural products as possible inhibitors for drug resistance in cancer. The molecular targets and the mechanisms of action of each natural product are also explained. Diverse drug resistance biomarkers were sensitive to natural products. P-glycoprotein and breast cancer resistance protein can be targeted by a large number of natural products. On the other hand, protein kinase C and topoisomerases were less sensitive to most of the studied natural products. The studies discussed in this review will provide a solid ground for scientists to explore the possible use of natural products in combination anticancer therapies to overcome drug resistance by targeting multiple drug resistance mechanisms. |
format | Online Article Text |
id | pubmed-8533186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85331862021-10-23 Targeting Drug Chemo-Resistance in Cancer Using Natural Products Talib, Wamidh H. Alsayed, Ahmad Riyad Barakat, Muna Abu-Taha, May Ibrahim Mahmod, Asma Ismail Biomedicines Review Cancer is one of the leading causes of death globally. The development of drug resistance is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms to reduce the therapeutic effects of anticancer drugs, thereby causing chemotherapy failure. Natural products are accessible, inexpensive, and less toxic sources of chemotherapeutic agents. Additionally, they have multiple mechanisms of action to inhibit various targets involved in the development of drug resistance. In this review, we have summarized the basic research and clinical applications of natural products as possible inhibitors for drug resistance in cancer. The molecular targets and the mechanisms of action of each natural product are also explained. Diverse drug resistance biomarkers were sensitive to natural products. P-glycoprotein and breast cancer resistance protein can be targeted by a large number of natural products. On the other hand, protein kinase C and topoisomerases were less sensitive to most of the studied natural products. The studies discussed in this review will provide a solid ground for scientists to explore the possible use of natural products in combination anticancer therapies to overcome drug resistance by targeting multiple drug resistance mechanisms. MDPI 2021-09-29 /pmc/articles/PMC8533186/ /pubmed/34680470 http://dx.doi.org/10.3390/biomedicines9101353 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Talib, Wamidh H. Alsayed, Ahmad Riyad Barakat, Muna Abu-Taha, May Ibrahim Mahmod, Asma Ismail Targeting Drug Chemo-Resistance in Cancer Using Natural Products |
title | Targeting Drug Chemo-Resistance in Cancer Using Natural Products |
title_full | Targeting Drug Chemo-Resistance in Cancer Using Natural Products |
title_fullStr | Targeting Drug Chemo-Resistance in Cancer Using Natural Products |
title_full_unstemmed | Targeting Drug Chemo-Resistance in Cancer Using Natural Products |
title_short | Targeting Drug Chemo-Resistance in Cancer Using Natural Products |
title_sort | targeting drug chemo-resistance in cancer using natural products |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533186/ https://www.ncbi.nlm.nih.gov/pubmed/34680470 http://dx.doi.org/10.3390/biomedicines9101353 |
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