Induced Pluripotent Stem Cell-Derived Cardiomyocytes with SCN5A R1623Q Mutation Associated with Severe Long QT Syndrome in Fetuses and Neonates Recapitulates Pathophysiological Phenotypes

SIMPLE SUMMARY: In this study, the induced pluripotent stem cell-derived cardiomyocyte model from a patient with long QT syndrome harboring a heterozygous Nav1.5 R1623Q mutation exhibited prolonged field potential duration corrected by Fridericia’s formula (FPDcF, analogous to QTcF). FPDcF was short...

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Detalles Bibliográficos
Autores principales: Hayama, Emiko, Furutani, Yoshiyuki, Kawaguchi, Nanako, Seki, Akiko, Nagashima, Yoji, Okita, Keisuke, Takeuchi, Daiji, Matsuoka, Rumiko, Inai, Kei, Hagiwara, Nobuhisa, Nakanishi, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533193/
https://www.ncbi.nlm.nih.gov/pubmed/34681161
http://dx.doi.org/10.3390/biology10101062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533193/
https://www.ncbi.nlm.nih.gov/pubmed/34681161
http://dx.doi.org/10.3390/biology10101062

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