Highly Potent, Selective, and Competitive Indole-Based MAO-B Inhibitors Protect PC12 Cells against 6-Hydroxydopamine- and Rotenone-Induced Oxidative Stress

Monoamine oxidase B (MAO-B) is responsible for dopamine metabolism and plays a key role in oxidative stress by changing the redox state of neuronal and glial cells. To date, no disease-modifying therapy for Parkinson’s disease (PD) has been identified. However, MAO-B inhibitors have emerged as a via...

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Detalles Bibliográficos
Autores principales: Elsherbeny, Mohamed H., Kim, Jushin, Gouda, Noha A., Gotina, Lizaveta, Cho, Jungsook, Pae, Ae Nim, Lee, Kyeong, Park, Ki Duk, Elkamhawy, Ahmed, Roh, Eun Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533206/
https://www.ncbi.nlm.nih.gov/pubmed/34679775
http://dx.doi.org/10.3390/antiox10101641

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