FRI-1 Is an Anti-Cancer Isoquinolinequinone That Inhibits the Mitochondrial Bioenergetics and Blocks Metabolic Shifts by Redox Disruption in Breast Cancer Cells

Since breast cancer (BC) cells are dependent on mitochondrial bioenergetics for promoting proliferation, survival, and metastasis, mitochondria highlight as an important target for anticancer drug discovery. FRI-1, methyl 1, 3-dimethyl-5, 8-dioxo-5, 8-dihydro-4-isoquinolinecarboxylate, was previousl...

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Detalles Bibliográficos
Autores principales: Córdova-Delgado, Miguel, Fuentes-Retamal, Sebastián, Palominos, Charlotte, López-Torres, Camila, Guzmán-Rivera, Daniela, Ramírez-Rodríguez, Oney, Araya-Maturana, Ramiro, Urra, Félix A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533268/
https://www.ncbi.nlm.nih.gov/pubmed/34679752
http://dx.doi.org/10.3390/antiox10101618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533268/
https://www.ncbi.nlm.nih.gov/pubmed/34679752
http://dx.doi.org/10.3390/antiox10101618

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