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ONC201 and an MEK Inhibitor Trametinib Synergistically Inhibit the Growth of Triple-Negative Breast Cancer Cells

Triple-negative breast cancer (TNBC) is a heterogeneous group of estrogen, progesterone, and HER2-negative breast cancers with poor clinical outcomes. The imipridone ONC201 is a G-protein-coupled dopamine receptor D2 modulator and an allosteric agonist of the mitochondrial protease caseinolytic prot...

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Detalles Bibliográficos
Autores principales:	Lim, Bora, Peterson, Christine B., Davis, Alexander, Cho, Elin, Pearson, Troy, Liu, Huey, Hwang, Minha, Ueno, Naoto Tada, Lee, Jangsoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533320/ https://www.ncbi.nlm.nih.gov/pubmed/34680527 http://dx.doi.org/10.3390/biomedicines9101410

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