Cargando…

A Perspective on the Development of c-Jun N-terminal Kinase Inhibitors as Therapeutics for Alzheimer’s Disease: Investigating Structure through Docking Studies

c-Jun N-terminal kinase (JNK) plays an important role in cell death caused by various stimuli. Because the isoform JNK3 is mainly expressed in the brain, it is believed to play a pivotal role in various neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), whic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cho, Hyunwook, Hah, Jung-Mi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533360/ https://www.ncbi.nlm.nih.gov/pubmed/34680547 http://dx.doi.org/10.3390/biomedicines9101431

Ejemplares similares

c-Jun N-Terminal Kinase Inhibitors as Potential Leads for New Therapeutics for Alzheimer’s Diseases
por: Hepp Rehfeldt, Stephanie Cristine, et al.
Publicado: (2020)

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease
por: Yarza, Ramon, et al.
Publicado: (2016)

Molecular docking of C-Jun-N-Terminal Kinase (Jnk) with amino-pyrimidine derivatives
por: Meenakumari, Krishnamoorthy, et al.
Publicado: (2020)

C-Jun N-terminal kinase inhibitors: Structural insight into kinase-inhibitor complexes
por: Duong, Men Thi Hoai, et al.
Publicado: (2020)

Inhibitors of c-Jun N-terminal kinases—JuNK no more?
por: Bogoyevitch, Marie A., et al.
Publicado: (2008)

c-Jun N-Terminal Kinase Signaling Inhibitors Under Development
por: Han, Sun-Young
Publicado: (2008)

Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors
por: Davis, Terence, et al.
Publicado: (2011)

c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1
por: Tian, Xiaodong, et al.
Publicado: (2021)

c-Jun N-Terminal Kinase as a Therapeutic Target in Experimental Autoimmune Encephalomyelitis
por: Bagnoud, Maud, et al.
Publicado: (2020)

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases
por: Guma, Monica, et al.
Publicado: (2012)

Jun N-terminal kinase signaling makes a face
por: Hursh, Deborah A., et al.
Publicado: (2016)

Activation of c-Jun N-Terminal Kinase, a Potential Therapeutic Target in Autoimmune Arthritis
por: Lai, Benjamin, et al.
Publicado: (2020)

Novel Tryptanthrin Derivatives with Selectivity as c–Jun N–Terminal Kinase (JNK) 3 Inhibitors
por: Schepetkin, Igor A., et al.
Publicado: (2023)

C‐Jun N‐terminal kinase signalling pathway in response to cisplatin
por: Yan, Dong, et al.
Publicado: (2016)

Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase
por: Biggi, Silvia, et al.
Publicado: (2017)

Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation
por: Anfinogenova, Nina D., et al.
Publicado: (2020)

The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
por: Chen, Jing, et al.
Publicado: (2021)

c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo
por: Sclip, A, et al.
Publicado: (2014)

Mechanism and Therapeutic Targets of c-Jun-N-Terminal Kinases Activation in Nonalcoholic Fatty Liver Disease
por: Min, Robert W. M., et al.
Publicado: (2022)

In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells
por: Kim, Byung-Jin, et al.
Publicado: (2016)

Myocardial protective effects of a c‐Jun N‐terminal kinase inhibitor in rats with brain death
por: Guo, Wenzhi, et al.
Publicado: (2016)

Stressor-Like Effects of c-Jun N-Terminal Kinase (JNK) Inhibition
por: Clarke, Melanie, et al.
Publicado: (2012)

c-Jun N-Terminal Kinase Phosphorylation Is a Biomarker of Plitidepsin Activity
por: Muñoz-Alonso, María J., et al.
Publicado: (2013)

C-Jun N-terminal kinases are required for oncolytic adenovirus-mediated autophagy
por: Klein, SR, et al.
Publicado: (2015)

Activation of c-Jun N-terminal kinase by Akabane virus is required for apoptosis
por: Mitomo, S., et al.
Publicado: (2016)

Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase
por: Marcus, David J., et al.
Publicado: (2015)

c-Jun N-Terminal Kinases (JNKs) in Myocardial and Cerebral Ischemia/Reperfusion Injury
por: Shvedova, Maria, et al.
Publicado: (2018)

Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell Migration
por: Andjelković, Ana, et al.
Publicado: (2018)

Role of c-Jun N-Terminal Kinases (JNKs) in Epilepsy and Metabolic Cognitive Impairment
por: Busquets, Oriol, et al.
Publicado: (2019)

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes
por: Yung, Justin Hou Ming, et al.
Publicado: (2020)

On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory
por: Rossato, Janine I., et al.
Publicado: (2022)

Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats
por: Plotnikov, Mark B., et al.
Publicado: (2019)

Suppression of Age-Related Macular Degeneration-like Pathology by c-Jun N-Terminal Kinase Inhibitor IQ-1S
por: Zhdankina, Anna A., et al.
Publicado: (2023)

Cardioprotective Effects of a Selective c-Jun N-terminal Kinase Inhibitor in a Rat Model of Myocardial Infarction
por: Plotnikov, Mark B., et al.
Publicado: (2023)

Protein Synthesis Inhibition and Activation of the c-Jun N-Terminal Kinase Are Potential Contributors to Cisplatin Ototoxicity
por: Nicholas, Brian D., et al.
Publicado: (2017)

Monosodium Urate in the Presence of RANKL Promotes Osteoclast Formation through Activation of c-Jun N-Terminal Kinase
por: Choe, Jung-Yoon, et al.
Publicado: (2015)

A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancer-associated membrane protease Prss14/epithin via protein kinase CβII
por: Yoon, Joobyoung, et al.
Publicado: (2020)

A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib
por: Ebelt, Nancy D., et al.
Publicado: (2017)

Neuroprotective Effects of a Novel Inhibitor of c-Jun N-Terminal Kinase in the Rat Model of Transient Focal Cerebral Ischemia
por: Plotnikov, Mark B., et al.
Publicado: (2020)

Design, synthesis and biological evaluation of novel O-substituted tryptanthrin oxime derivatives as c-Jun N-terminal kinase inhibitors
por: Schepetkin, Igor A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ot2qu9f210593k3998hkf00mjl