Cargando…
Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials
Due to the demographic change, medicine faces a growing demand for tissue engineering solutions and implants. Often, satisfying tissue regeneration is difficult to achieve especially when co-morbidities hamper the healing process. As a novel strategy, we propose the incorporation of zinc oxide nanop...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533365/ https://www.ncbi.nlm.nih.gov/pubmed/34680579 http://dx.doi.org/10.3390/biomedicines9101462 |
_version_ | 1784587295299469312 |
---|---|
author | Wiesmann, Nadine Mendler, Simone Buhr, Christoph R. Ritz, Ulrike Kämmerer, Peer W. Brieger, Juergen |
author_facet | Wiesmann, Nadine Mendler, Simone Buhr, Christoph R. Ritz, Ulrike Kämmerer, Peer W. Brieger, Juergen |
author_sort | Wiesmann, Nadine |
collection | PubMed |
description | Due to the demographic change, medicine faces a growing demand for tissue engineering solutions and implants. Often, satisfying tissue regeneration is difficult to achieve especially when co-morbidities hamper the healing process. As a novel strategy, we propose the incorporation of zinc oxide nanoparticles (ZnO NPs) into biomaterials to improve tissue regeneration. Due to their wide range of biocompatibility and their antibacterial properties, ZnO NPs are already discussed for different medical applications. As there are versatile possibilities of modifying their form, size, and function, they are becoming increasingly attractive for tissue engineering. In our study, in addition to antibacterial effects of ZnO NPs, we show for the first time that ZnO NPs can foster the metabolic activity of fibroblasts as well as endothelial cells, both cell types being crucial for successful implant integration. With the gelatin sponge method performed on the chicken embryo’s chorioallantoic membrane (CAM), we furthermore confirmed the high biocompatibility of ZnO NPs. In summary, we found ZnO NPs to have very favorable properties for the modification of biomaterials. Here, incorporation of ZnO NPs could help to guide the tissue reaction and promote complication-free healing. |
format | Online Article Text |
id | pubmed-8533365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85333652021-10-23 Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials Wiesmann, Nadine Mendler, Simone Buhr, Christoph R. Ritz, Ulrike Kämmerer, Peer W. Brieger, Juergen Biomedicines Article Due to the demographic change, medicine faces a growing demand for tissue engineering solutions and implants. Often, satisfying tissue regeneration is difficult to achieve especially when co-morbidities hamper the healing process. As a novel strategy, we propose the incorporation of zinc oxide nanoparticles (ZnO NPs) into biomaterials to improve tissue regeneration. Due to their wide range of biocompatibility and their antibacterial properties, ZnO NPs are already discussed for different medical applications. As there are versatile possibilities of modifying their form, size, and function, they are becoming increasingly attractive for tissue engineering. In our study, in addition to antibacterial effects of ZnO NPs, we show for the first time that ZnO NPs can foster the metabolic activity of fibroblasts as well as endothelial cells, both cell types being crucial for successful implant integration. With the gelatin sponge method performed on the chicken embryo’s chorioallantoic membrane (CAM), we furthermore confirmed the high biocompatibility of ZnO NPs. In summary, we found ZnO NPs to have very favorable properties for the modification of biomaterials. Here, incorporation of ZnO NPs could help to guide the tissue reaction and promote complication-free healing. MDPI 2021-10-13 /pmc/articles/PMC8533365/ /pubmed/34680579 http://dx.doi.org/10.3390/biomedicines9101462 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wiesmann, Nadine Mendler, Simone Buhr, Christoph R. Ritz, Ulrike Kämmerer, Peer W. Brieger, Juergen Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials |
title | Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials |
title_full | Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials |
title_fullStr | Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials |
title_full_unstemmed | Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials |
title_short | Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials |
title_sort | zinc oxide nanoparticles exhibit favorable properties to promote tissue integration of biomaterials |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533365/ https://www.ncbi.nlm.nih.gov/pubmed/34680579 http://dx.doi.org/10.3390/biomedicines9101462 |
work_keys_str_mv | AT wiesmannnadine zincoxidenanoparticlesexhibitfavorablepropertiestopromotetissueintegrationofbiomaterials AT mendlersimone zincoxidenanoparticlesexhibitfavorablepropertiestopromotetissueintegrationofbiomaterials AT buhrchristophr zincoxidenanoparticlesexhibitfavorablepropertiestopromotetissueintegrationofbiomaterials AT ritzulrike zincoxidenanoparticlesexhibitfavorablepropertiestopromotetissueintegrationofbiomaterials AT kammererpeerw zincoxidenanoparticlesexhibitfavorablepropertiestopromotetissueintegrationofbiomaterials AT briegerjuergen zincoxidenanoparticlesexhibitfavorablepropertiestopromotetissueintegrationofbiomaterials |