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Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu
Nanoparticles (NPs) in contact with a biological medium are rapidly comprehended by a number of protein molecules resulting in the formation of an NP–protein complex called protein corona (PC). The cell sees the protein-coated NPs as the synthetic identity is masked by protein surfacing. The PC form...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533425/ https://www.ncbi.nlm.nih.gov/pubmed/34680613 http://dx.doi.org/10.3390/biomedicines9101496 |
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author | Akhter, Md Habban Khalilullah, Habibullah Gupta, Manish Alfaleh, Mohamed A. Alhakamy, Nabil A. Riadi, Yassine Md, Shadab |
author_facet | Akhter, Md Habban Khalilullah, Habibullah Gupta, Manish Alfaleh, Mohamed A. Alhakamy, Nabil A. Riadi, Yassine Md, Shadab |
author_sort | Akhter, Md Habban |
collection | PubMed |
description | Nanoparticles (NPs) in contact with a biological medium are rapidly comprehended by a number of protein molecules resulting in the formation of an NP–protein complex called protein corona (PC). The cell sees the protein-coated NPs as the synthetic identity is masked by protein surfacing. The PC formation ultimately has a substantial impact on various biological processes including drug release, drug targeting, cell recognition, biodistribution, cellular uptake, and therapeutic efficacy. Further, the composition of PC is largely influenced by the physico-chemical properties of NPs viz. the size, shape, surface charge, and surface chemistry in the biological milieu. However, the change in the biological responses of the new substrate depends on the quantity of protein access by the NPs. The PC-layered NPs act as new biological entities and are recognized as different targeting agents for the receptor-mediated ingress of therapeutics in the biological cells. The corona-enveloped NPs have both pros and cons in the biological system. The review provides a brief insight into the impact of biomolecules on nanomaterials carrying cargos and their ultimate fate in the biological milieu. |
format | Online Article Text |
id | pubmed-8533425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85334252021-10-23 Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu Akhter, Md Habban Khalilullah, Habibullah Gupta, Manish Alfaleh, Mohamed A. Alhakamy, Nabil A. Riadi, Yassine Md, Shadab Biomedicines Review Nanoparticles (NPs) in contact with a biological medium are rapidly comprehended by a number of protein molecules resulting in the formation of an NP–protein complex called protein corona (PC). The cell sees the protein-coated NPs as the synthetic identity is masked by protein surfacing. The PC formation ultimately has a substantial impact on various biological processes including drug release, drug targeting, cell recognition, biodistribution, cellular uptake, and therapeutic efficacy. Further, the composition of PC is largely influenced by the physico-chemical properties of NPs viz. the size, shape, surface charge, and surface chemistry in the biological milieu. However, the change in the biological responses of the new substrate depends on the quantity of protein access by the NPs. The PC-layered NPs act as new biological entities and are recognized as different targeting agents for the receptor-mediated ingress of therapeutics in the biological cells. The corona-enveloped NPs have both pros and cons in the biological system. The review provides a brief insight into the impact of biomolecules on nanomaterials carrying cargos and their ultimate fate in the biological milieu. MDPI 2021-10-19 /pmc/articles/PMC8533425/ /pubmed/34680613 http://dx.doi.org/10.3390/biomedicines9101496 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Akhter, Md Habban Khalilullah, Habibullah Gupta, Manish Alfaleh, Mohamed A. Alhakamy, Nabil A. Riadi, Yassine Md, Shadab Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu |
title | Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu |
title_full | Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu |
title_fullStr | Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu |
title_full_unstemmed | Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu |
title_short | Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu |
title_sort | impact of protein corona on the biological identity of nanomedicine: understanding the fate of nanomaterials in the biological milieu |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533425/ https://www.ncbi.nlm.nih.gov/pubmed/34680613 http://dx.doi.org/10.3390/biomedicines9101496 |
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