Cargando…

Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu

Nanoparticles (NPs) in contact with a biological medium are rapidly comprehended by a number of protein molecules resulting in the formation of an NP–protein complex called protein corona (PC). The cell sees the protein-coated NPs as the synthetic identity is masked by protein surfacing. The PC form...

Descripción completa

Detalles Bibliográficos
Autores principales: Akhter, Md Habban, Khalilullah, Habibullah, Gupta, Manish, Alfaleh, Mohamed A., Alhakamy, Nabil A., Riadi, Yassine, Md, Shadab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533425/
https://www.ncbi.nlm.nih.gov/pubmed/34680613
http://dx.doi.org/10.3390/biomedicines9101496
_version_ 1784587309684883456
author Akhter, Md Habban
Khalilullah, Habibullah
Gupta, Manish
Alfaleh, Mohamed A.
Alhakamy, Nabil A.
Riadi, Yassine
Md, Shadab
author_facet Akhter, Md Habban
Khalilullah, Habibullah
Gupta, Manish
Alfaleh, Mohamed A.
Alhakamy, Nabil A.
Riadi, Yassine
Md, Shadab
author_sort Akhter, Md Habban
collection PubMed
description Nanoparticles (NPs) in contact with a biological medium are rapidly comprehended by a number of protein molecules resulting in the formation of an NP–protein complex called protein corona (PC). The cell sees the protein-coated NPs as the synthetic identity is masked by protein surfacing. The PC formation ultimately has a substantial impact on various biological processes including drug release, drug targeting, cell recognition, biodistribution, cellular uptake, and therapeutic efficacy. Further, the composition of PC is largely influenced by the physico-chemical properties of NPs viz. the size, shape, surface charge, and surface chemistry in the biological milieu. However, the change in the biological responses of the new substrate depends on the quantity of protein access by the NPs. The PC-layered NPs act as new biological entities and are recognized as different targeting agents for the receptor-mediated ingress of therapeutics in the biological cells. The corona-enveloped NPs have both pros and cons in the biological system. The review provides a brief insight into the impact of biomolecules on nanomaterials carrying cargos and their ultimate fate in the biological milieu.
format Online
Article
Text
id pubmed-8533425
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85334252021-10-23 Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu Akhter, Md Habban Khalilullah, Habibullah Gupta, Manish Alfaleh, Mohamed A. Alhakamy, Nabil A. Riadi, Yassine Md, Shadab Biomedicines Review Nanoparticles (NPs) in contact with a biological medium are rapidly comprehended by a number of protein molecules resulting in the formation of an NP–protein complex called protein corona (PC). The cell sees the protein-coated NPs as the synthetic identity is masked by protein surfacing. The PC formation ultimately has a substantial impact on various biological processes including drug release, drug targeting, cell recognition, biodistribution, cellular uptake, and therapeutic efficacy. Further, the composition of PC is largely influenced by the physico-chemical properties of NPs viz. the size, shape, surface charge, and surface chemistry in the biological milieu. However, the change in the biological responses of the new substrate depends on the quantity of protein access by the NPs. The PC-layered NPs act as new biological entities and are recognized as different targeting agents for the receptor-mediated ingress of therapeutics in the biological cells. The corona-enveloped NPs have both pros and cons in the biological system. The review provides a brief insight into the impact of biomolecules on nanomaterials carrying cargos and their ultimate fate in the biological milieu. MDPI 2021-10-19 /pmc/articles/PMC8533425/ /pubmed/34680613 http://dx.doi.org/10.3390/biomedicines9101496 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Akhter, Md Habban
Khalilullah, Habibullah
Gupta, Manish
Alfaleh, Mohamed A.
Alhakamy, Nabil A.
Riadi, Yassine
Md, Shadab
Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu
title Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu
title_full Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu
title_fullStr Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu
title_full_unstemmed Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu
title_short Impact of Protein Corona on the Biological Identity of Nanomedicine: Understanding the Fate of Nanomaterials in the Biological Milieu
title_sort impact of protein corona on the biological identity of nanomedicine: understanding the fate of nanomaterials in the biological milieu
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533425/
https://www.ncbi.nlm.nih.gov/pubmed/34680613
http://dx.doi.org/10.3390/biomedicines9101496
work_keys_str_mv AT akhtermdhabban impactofproteincoronaonthebiologicalidentityofnanomedicineunderstandingthefateofnanomaterialsinthebiologicalmilieu
AT khalilullahhabibullah impactofproteincoronaonthebiologicalidentityofnanomedicineunderstandingthefateofnanomaterialsinthebiologicalmilieu
AT guptamanish impactofproteincoronaonthebiologicalidentityofnanomedicineunderstandingthefateofnanomaterialsinthebiologicalmilieu
AT alfalehmohameda impactofproteincoronaonthebiologicalidentityofnanomedicineunderstandingthefateofnanomaterialsinthebiologicalmilieu
AT alhakamynabila impactofproteincoronaonthebiologicalidentityofnanomedicineunderstandingthefateofnanomaterialsinthebiologicalmilieu
AT riadiyassine impactofproteincoronaonthebiologicalidentityofnanomedicineunderstandingthefateofnanomaterialsinthebiologicalmilieu
AT mdshadab impactofproteincoronaonthebiologicalidentityofnanomedicineunderstandingthefateofnanomaterialsinthebiologicalmilieu