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Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or Irisin, Predisposes to More Serious COVID-19 Course

Analysis of liver biopsy specimens showed that SARS-CoV-2 might have led to liver damage. This study aimed to evaluate the role of selected hepatokines and myokines in the development and progression of COVID-19. Seventy patients with laboratory-confirmed COVID-19 and 20 healthy volunteers were enro...

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Autores principales: Kukla, Michał, Menżyk, Tomasz, Dembiński, Marcin, Winiarski, Marek, Garlicki, Aleksander, Bociąga-Jasik, Monika, Skonieczna, Magdalena, Hudy, Dorota, Maziarz, Barbara, Kuśnierz-Cabala, Beata, Kapusta, Maria, Skladany, Lubomir, Grgurevic, Ivica, Mikolasevic, Ivana, Filipec-Kanizaj, Tajana, Wójcik-Bugajska, Małgorzata, Grodzicki, Tomasz, Rogula, Tomasz, Stygar, Dominika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533535/
https://www.ncbi.nlm.nih.gov/pubmed/34680053
http://dx.doi.org/10.3390/biom11101422
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author Kukla, Michał
Menżyk, Tomasz
Dembiński, Marcin
Winiarski, Marek
Garlicki, Aleksander
Bociąga-Jasik, Monika
Skonieczna, Magdalena
Hudy, Dorota
Maziarz, Barbara
Kuśnierz-Cabala, Beata
Kapusta, Maria
Skladany, Lubomir
Grgurevic, Ivica
Mikolasevic, Ivana
Filipec-Kanizaj, Tajana
Wójcik-Bugajska, Małgorzata
Grodzicki, Tomasz
Rogula, Tomasz
Stygar, Dominika
author_facet Kukla, Michał
Menżyk, Tomasz
Dembiński, Marcin
Winiarski, Marek
Garlicki, Aleksander
Bociąga-Jasik, Monika
Skonieczna, Magdalena
Hudy, Dorota
Maziarz, Barbara
Kuśnierz-Cabala, Beata
Kapusta, Maria
Skladany, Lubomir
Grgurevic, Ivica
Mikolasevic, Ivana
Filipec-Kanizaj, Tajana
Wójcik-Bugajska, Małgorzata
Grodzicki, Tomasz
Rogula, Tomasz
Stygar, Dominika
author_sort Kukla, Michał
collection PubMed
description Analysis of liver biopsy specimens showed that SARS-CoV-2 might have led to liver damage. This study aimed to evaluate the role of selected hepatokines and myokines in the development and progression of COVID-19. Seventy patients with laboratory-confirmed COVID-19 and 20 healthy volunteers were enrolled in the study. Irisin, pentraxin 3, fetuin-A, and FGF-21 serum concentrations and biochemical parameters were assessed using an immunoenzymatic method with commercially available enzyme immunoassay (EIA) or enzyme-linked immunosorbent assay (ELISA) kits. Serum fetuin-A concentrations were significantly decreased in COVID-19 patients compared to healthy volunteers. The serum concentration of FGF-21 was significantly increased in obese COVID-19 patients compared to overweight ones. Moreover, the FGF-21 level was higher in COVID-19 patients diagnosed with metabolic syndrome than in patients without metabolic syndrome. PTX3 concentration was higher in COVID-19 patients with higher HOMA-IR values than those with lower HOMA-IR values. COVID-19 patients with HOMA-IR ≤ 3 and >3 had significantly lower fetuin-A levels than the control group. Irisin concentration was significantly decreased in the HOMA-IR ≤ 3 COVID-19 subgroup when comparing with the control group. Lower levels of fetuin-A observed in COVID-19 patients despite higher HOMA-IR, CRP, and ferritin levels, pneumonia, patients requiring ICU care suggests that fetuin-A deficiency predisposes to more severe COVID-19 course. Upregulated pentraxin 3 may be used as a potential predictor of COVID-19 severity.
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spelling pubmed-85335352021-10-23 Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or Irisin, Predisposes to More Serious COVID-19 Course Kukla, Michał Menżyk, Tomasz Dembiński, Marcin Winiarski, Marek Garlicki, Aleksander Bociąga-Jasik, Monika Skonieczna, Magdalena Hudy, Dorota Maziarz, Barbara Kuśnierz-Cabala, Beata Kapusta, Maria Skladany, Lubomir Grgurevic, Ivica Mikolasevic, Ivana Filipec-Kanizaj, Tajana Wójcik-Bugajska, Małgorzata Grodzicki, Tomasz Rogula, Tomasz Stygar, Dominika Biomolecules Article Analysis of liver biopsy specimens showed that SARS-CoV-2 might have led to liver damage. This study aimed to evaluate the role of selected hepatokines and myokines in the development and progression of COVID-19. Seventy patients with laboratory-confirmed COVID-19 and 20 healthy volunteers were enrolled in the study. Irisin, pentraxin 3, fetuin-A, and FGF-21 serum concentrations and biochemical parameters were assessed using an immunoenzymatic method with commercially available enzyme immunoassay (EIA) or enzyme-linked immunosorbent assay (ELISA) kits. Serum fetuin-A concentrations were significantly decreased in COVID-19 patients compared to healthy volunteers. The serum concentration of FGF-21 was significantly increased in obese COVID-19 patients compared to overweight ones. Moreover, the FGF-21 level was higher in COVID-19 patients diagnosed with metabolic syndrome than in patients without metabolic syndrome. PTX3 concentration was higher in COVID-19 patients with higher HOMA-IR values than those with lower HOMA-IR values. COVID-19 patients with HOMA-IR ≤ 3 and >3 had significantly lower fetuin-A levels than the control group. Irisin concentration was significantly decreased in the HOMA-IR ≤ 3 COVID-19 subgroup when comparing with the control group. Lower levels of fetuin-A observed in COVID-19 patients despite higher HOMA-IR, CRP, and ferritin levels, pneumonia, patients requiring ICU care suggests that fetuin-A deficiency predisposes to more severe COVID-19 course. Upregulated pentraxin 3 may be used as a potential predictor of COVID-19 severity. MDPI 2021-09-28 /pmc/articles/PMC8533535/ /pubmed/34680053 http://dx.doi.org/10.3390/biom11101422 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kukla, Michał
Menżyk, Tomasz
Dembiński, Marcin
Winiarski, Marek
Garlicki, Aleksander
Bociąga-Jasik, Monika
Skonieczna, Magdalena
Hudy, Dorota
Maziarz, Barbara
Kuśnierz-Cabala, Beata
Kapusta, Maria
Skladany, Lubomir
Grgurevic, Ivica
Mikolasevic, Ivana
Filipec-Kanizaj, Tajana
Wójcik-Bugajska, Małgorzata
Grodzicki, Tomasz
Rogula, Tomasz
Stygar, Dominika
Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or Irisin, Predisposes to More Serious COVID-19 Course
title Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or Irisin, Predisposes to More Serious COVID-19 Course
title_full Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or Irisin, Predisposes to More Serious COVID-19 Course
title_fullStr Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or Irisin, Predisposes to More Serious COVID-19 Course
title_full_unstemmed Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or Irisin, Predisposes to More Serious COVID-19 Course
title_short Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or Irisin, Predisposes to More Serious COVID-19 Course
title_sort fetuin-a deficiency but not pentraxin 3, fgf-21, or irisin, predisposes to more serious covid-19 course
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533535/
https://www.ncbi.nlm.nih.gov/pubmed/34680053
http://dx.doi.org/10.3390/biom11101422
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