Cargando…
Sex Hormone-Binding Globulin (SHBG) in Cerebrospinal Fluid Does Not Discriminate between the Main FTLD Pathological Subtypes but Correlates with Cognitive Decline in FTLD Tauopathies
Biomarkers to discriminate the main pathologies underlying frontotemporal lobar degeneration (FTLD-Tau, FTLD-TDP) are lacking. Our previous FTLD cerebrospinal fluid (CSF) proteome study revealed that sex hormone-binding globulin (SHBG) was specifically increased in FTLD-Tau patients. Here we investi...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533538/ https://www.ncbi.nlm.nih.gov/pubmed/34680117 http://dx.doi.org/10.3390/biom11101484 |
_version_ | 1784587337811886080 |
---|---|
author | del Campo, Marta Pijnenburg, Yolande A. L. Chen-Plotkin, Alice Irwin, David J. Grossman, Murray Twaalfhoven, Harry A. M. Hu, William T. Meeter, Lieke H. van Swieten, John Vermunt, Lisa Martens, Frans Heijboer, Annemieke C. Teunissen, Charlotte E. |
author_facet | del Campo, Marta Pijnenburg, Yolande A. L. Chen-Plotkin, Alice Irwin, David J. Grossman, Murray Twaalfhoven, Harry A. M. Hu, William T. Meeter, Lieke H. van Swieten, John Vermunt, Lisa Martens, Frans Heijboer, Annemieke C. Teunissen, Charlotte E. |
author_sort | del Campo, Marta |
collection | PubMed |
description | Biomarkers to discriminate the main pathologies underlying frontotemporal lobar degeneration (FTLD-Tau, FTLD-TDP) are lacking. Our previous FTLD cerebrospinal fluid (CSF) proteome study revealed that sex hormone-binding globulin (SHBG) was specifically increased in FTLD-Tau patients. Here we investigated the potential of CSF SHBG as a novel biomarker discriminating the main FTLD pathological subtypes. SHBG was measured in CSF samples from patients with FTLD-Tau (n = 23), FTLD-TDP (n = 29) and controls (n = 33) using an automated electro-chemiluminescent immunoassay. Differences in CSF SHBG levels across groups, as well as its association with CSF YKL40, pTau181/total-Tau ratio and cognitive function were analyzed. CSF SHBG did not differ across groups, though a trend towards elevated levels in FTLD-Tau cases compared to FTLD-TDP and controls was observed. CSF SHBG levels were not associated with either CSF YKL40 or the p/tTau ratio. They, however, inversely correlated with the MMSE score (r = −0.307, p = 0.011), an association likely driven by the FTLD-Tau group (r FTLD-Tau = −0.38; r FTLD-TDP = −0.02). CSF SHBG is not a suitable biomarker to discriminate FTLD-Tau from FTLD-TDP. |
format | Online Article Text |
id | pubmed-8533538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85335382021-10-23 Sex Hormone-Binding Globulin (SHBG) in Cerebrospinal Fluid Does Not Discriminate between the Main FTLD Pathological Subtypes but Correlates with Cognitive Decline in FTLD Tauopathies del Campo, Marta Pijnenburg, Yolande A. L. Chen-Plotkin, Alice Irwin, David J. Grossman, Murray Twaalfhoven, Harry A. M. Hu, William T. Meeter, Lieke H. van Swieten, John Vermunt, Lisa Martens, Frans Heijboer, Annemieke C. Teunissen, Charlotte E. Biomolecules Brief Report Biomarkers to discriminate the main pathologies underlying frontotemporal lobar degeneration (FTLD-Tau, FTLD-TDP) are lacking. Our previous FTLD cerebrospinal fluid (CSF) proteome study revealed that sex hormone-binding globulin (SHBG) was specifically increased in FTLD-Tau patients. Here we investigated the potential of CSF SHBG as a novel biomarker discriminating the main FTLD pathological subtypes. SHBG was measured in CSF samples from patients with FTLD-Tau (n = 23), FTLD-TDP (n = 29) and controls (n = 33) using an automated electro-chemiluminescent immunoassay. Differences in CSF SHBG levels across groups, as well as its association with CSF YKL40, pTau181/total-Tau ratio and cognitive function were analyzed. CSF SHBG did not differ across groups, though a trend towards elevated levels in FTLD-Tau cases compared to FTLD-TDP and controls was observed. CSF SHBG levels were not associated with either CSF YKL40 or the p/tTau ratio. They, however, inversely correlated with the MMSE score (r = −0.307, p = 0.011), an association likely driven by the FTLD-Tau group (r FTLD-Tau = −0.38; r FTLD-TDP = −0.02). CSF SHBG is not a suitable biomarker to discriminate FTLD-Tau from FTLD-TDP. MDPI 2021-10-08 /pmc/articles/PMC8533538/ /pubmed/34680117 http://dx.doi.org/10.3390/biom11101484 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report del Campo, Marta Pijnenburg, Yolande A. L. Chen-Plotkin, Alice Irwin, David J. Grossman, Murray Twaalfhoven, Harry A. M. Hu, William T. Meeter, Lieke H. van Swieten, John Vermunt, Lisa Martens, Frans Heijboer, Annemieke C. Teunissen, Charlotte E. Sex Hormone-Binding Globulin (SHBG) in Cerebrospinal Fluid Does Not Discriminate between the Main FTLD Pathological Subtypes but Correlates with Cognitive Decline in FTLD Tauopathies |
title | Sex Hormone-Binding Globulin (SHBG) in Cerebrospinal Fluid Does Not Discriminate between the Main FTLD Pathological Subtypes but Correlates with Cognitive Decline in FTLD Tauopathies |
title_full | Sex Hormone-Binding Globulin (SHBG) in Cerebrospinal Fluid Does Not Discriminate between the Main FTLD Pathological Subtypes but Correlates with Cognitive Decline in FTLD Tauopathies |
title_fullStr | Sex Hormone-Binding Globulin (SHBG) in Cerebrospinal Fluid Does Not Discriminate between the Main FTLD Pathological Subtypes but Correlates with Cognitive Decline in FTLD Tauopathies |
title_full_unstemmed | Sex Hormone-Binding Globulin (SHBG) in Cerebrospinal Fluid Does Not Discriminate between the Main FTLD Pathological Subtypes but Correlates with Cognitive Decline in FTLD Tauopathies |
title_short | Sex Hormone-Binding Globulin (SHBG) in Cerebrospinal Fluid Does Not Discriminate between the Main FTLD Pathological Subtypes but Correlates with Cognitive Decline in FTLD Tauopathies |
title_sort | sex hormone-binding globulin (shbg) in cerebrospinal fluid does not discriminate between the main ftld pathological subtypes but correlates with cognitive decline in ftld tauopathies |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533538/ https://www.ncbi.nlm.nih.gov/pubmed/34680117 http://dx.doi.org/10.3390/biom11101484 |
work_keys_str_mv | AT delcampomarta sexhormonebindingglobulinshbgincerebrospinalfluiddoesnotdiscriminatebetweenthemainftldpathologicalsubtypesbutcorrelateswithcognitivedeclineinftldtauopathies AT pijnenburgyolandeal sexhormonebindingglobulinshbgincerebrospinalfluiddoesnotdiscriminatebetweenthemainftldpathologicalsubtypesbutcorrelateswithcognitivedeclineinftldtauopathies AT chenplotkinalice sexhormonebindingglobulinshbgincerebrospinalfluiddoesnotdiscriminatebetweenthemainftldpathologicalsubtypesbutcorrelateswithcognitivedeclineinftldtauopathies AT irwindavidj sexhormonebindingglobulinshbgincerebrospinalfluiddoesnotdiscriminatebetweenthemainftldpathologicalsubtypesbutcorrelateswithcognitivedeclineinftldtauopathies AT grossmanmurray sexhormonebindingglobulinshbgincerebrospinalfluiddoesnotdiscriminatebetweenthemainftldpathologicalsubtypesbutcorrelateswithcognitivedeclineinftldtauopathies AT twaalfhovenharryam sexhormonebindingglobulinshbgincerebrospinalfluiddoesnotdiscriminatebetweenthemainftldpathologicalsubtypesbutcorrelateswithcognitivedeclineinftldtauopathies AT huwilliamt sexhormonebindingglobulinshbgincerebrospinalfluiddoesnotdiscriminatebetweenthemainftldpathologicalsubtypesbutcorrelateswithcognitivedeclineinftldtauopathies AT meeterliekeh sexhormonebindingglobulinshbgincerebrospinalfluiddoesnotdiscriminatebetweenthemainftldpathologicalsubtypesbutcorrelateswithcognitivedeclineinftldtauopathies AT vanswietenjohn sexhormonebindingglobulinshbgincerebrospinalfluiddoesnotdiscriminatebetweenthemainftldpathologicalsubtypesbutcorrelateswithcognitivedeclineinftldtauopathies AT vermuntlisa sexhormonebindingglobulinshbgincerebrospinalfluiddoesnotdiscriminatebetweenthemainftldpathologicalsubtypesbutcorrelateswithcognitivedeclineinftldtauopathies AT martensfrans sexhormonebindingglobulinshbgincerebrospinalfluiddoesnotdiscriminatebetweenthemainftldpathologicalsubtypesbutcorrelateswithcognitivedeclineinftldtauopathies AT heijboerannemiekec sexhormonebindingglobulinshbgincerebrospinalfluiddoesnotdiscriminatebetweenthemainftldpathologicalsubtypesbutcorrelateswithcognitivedeclineinftldtauopathies AT teunissencharlottee sexhormonebindingglobulinshbgincerebrospinalfluiddoesnotdiscriminatebetweenthemainftldpathologicalsubtypesbutcorrelateswithcognitivedeclineinftldtauopathies |