Cargando…
Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis
Angiogenesis is considered to be one of the key stages in the development of endometriosis. Recent studies indicate that bone morphogenetic proteins (BMPs) and their receptors (BMPR) may play an important role in the angiogenesis process. In the literature, however, there is a lack of publications c...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533551/ https://www.ncbi.nlm.nih.gov/pubmed/34680408 http://dx.doi.org/10.3390/biomedicines9101292 |
_version_ | 1784587341018431488 |
---|---|
author | Janusz, Joanna Janusz, Aleksandra Kondera-Anasz, Zdzisława Sikora, Justyna Smycz-Kubańska, Marta Englisz, Aleksandra Wendlocha, Dominika Mielczarek-Palacz, Aleksandra |
author_facet | Janusz, Joanna Janusz, Aleksandra Kondera-Anasz, Zdzisława Sikora, Justyna Smycz-Kubańska, Marta Englisz, Aleksandra Wendlocha, Dominika Mielczarek-Palacz, Aleksandra |
author_sort | Janusz, Joanna |
collection | PubMed |
description | Angiogenesis is considered to be one of the key stages in the development of endometriosis. Recent studies indicate that bone morphogenetic proteins (BMPs) and their receptors (BMPR) may play an important role in the angiogenesis process. In the literature, however, there is a lack of publications concerning binding BMPs and their receptors with the pathogenesis of endometriosis. The aim of the study was to determine the role of soluble bone morphogenetic proteins, BMP-2 and BMP-7, and their receptors, ALK-1 and BMPR2, in the process of the formation and development of endometriosis. Peritoneal fluid was collected in the proliferative phase of the menstrual cycle, from 80 women aged 21–49 years (mean age 31.3 ± 6.7 years) undergoing laparoscopy to determine the causes of primary infertility. The study involved 60 women in the I, II, III, and IV stages of the disease. The reference group consisted of 20 women who did not have endometriosis or other lesions in the pelvic area. The concentration in the peritoneal fluid of women with endometriosis was compared to the concentration of this parameter in the reference group, and a statistically significant reduction in the concentration of the BMP-2 molecule was found, as well as increasing concentrations of BMP-7, ALK-1, and BMPR2. BMP-2 and BMP-7 and their soluble receptors, ALK-1 and BMPR2, are involved in the formation of endometriosis. The changes in the concentrations of most of the tested parameters demonstrated in the study, especially in the early stages of the disease, may indicate the more effective formation of new blood vessels in this period. |
format | Online Article Text |
id | pubmed-8533551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85335512021-10-23 Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis Janusz, Joanna Janusz, Aleksandra Kondera-Anasz, Zdzisława Sikora, Justyna Smycz-Kubańska, Marta Englisz, Aleksandra Wendlocha, Dominika Mielczarek-Palacz, Aleksandra Biomedicines Article Angiogenesis is considered to be one of the key stages in the development of endometriosis. Recent studies indicate that bone morphogenetic proteins (BMPs) and their receptors (BMPR) may play an important role in the angiogenesis process. In the literature, however, there is a lack of publications concerning binding BMPs and their receptors with the pathogenesis of endometriosis. The aim of the study was to determine the role of soluble bone morphogenetic proteins, BMP-2 and BMP-7, and their receptors, ALK-1 and BMPR2, in the process of the formation and development of endometriosis. Peritoneal fluid was collected in the proliferative phase of the menstrual cycle, from 80 women aged 21–49 years (mean age 31.3 ± 6.7 years) undergoing laparoscopy to determine the causes of primary infertility. The study involved 60 women in the I, II, III, and IV stages of the disease. The reference group consisted of 20 women who did not have endometriosis or other lesions in the pelvic area. The concentration in the peritoneal fluid of women with endometriosis was compared to the concentration of this parameter in the reference group, and a statistically significant reduction in the concentration of the BMP-2 molecule was found, as well as increasing concentrations of BMP-7, ALK-1, and BMPR2. BMP-2 and BMP-7 and their soluble receptors, ALK-1 and BMPR2, are involved in the formation of endometriosis. The changes in the concentrations of most of the tested parameters demonstrated in the study, especially in the early stages of the disease, may indicate the more effective formation of new blood vessels in this period. MDPI 2021-09-22 /pmc/articles/PMC8533551/ /pubmed/34680408 http://dx.doi.org/10.3390/biomedicines9101292 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Janusz, Joanna Janusz, Aleksandra Kondera-Anasz, Zdzisława Sikora, Justyna Smycz-Kubańska, Marta Englisz, Aleksandra Wendlocha, Dominika Mielczarek-Palacz, Aleksandra Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis |
title | Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis |
title_full | Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis |
title_fullStr | Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis |
title_full_unstemmed | Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis |
title_short | Participation of Selected Soluble BMP-2 and BMP-7 Bone Morphogenetic Proteins and Their Soluble Type I ALK-1 and Type II BMPR2 Receptors in Formation and Development of Endometriosis |
title_sort | participation of selected soluble bmp-2 and bmp-7 bone morphogenetic proteins and their soluble type i alk-1 and type ii bmpr2 receptors in formation and development of endometriosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533551/ https://www.ncbi.nlm.nih.gov/pubmed/34680408 http://dx.doi.org/10.3390/biomedicines9101292 |
work_keys_str_mv | AT januszjoanna participationofselectedsolublebmp2andbmp7bonemorphogeneticproteinsandtheirsolubletypeialk1andtypeiibmpr2receptorsinformationanddevelopmentofendometriosis AT januszaleksandra participationofselectedsolublebmp2andbmp7bonemorphogeneticproteinsandtheirsolubletypeialk1andtypeiibmpr2receptorsinformationanddevelopmentofendometriosis AT konderaanaszzdzisława participationofselectedsolublebmp2andbmp7bonemorphogeneticproteinsandtheirsolubletypeialk1andtypeiibmpr2receptorsinformationanddevelopmentofendometriosis AT sikorajustyna participationofselectedsolublebmp2andbmp7bonemorphogeneticproteinsandtheirsolubletypeialk1andtypeiibmpr2receptorsinformationanddevelopmentofendometriosis AT smyczkubanskamarta participationofselectedsolublebmp2andbmp7bonemorphogeneticproteinsandtheirsolubletypeialk1andtypeiibmpr2receptorsinformationanddevelopmentofendometriosis AT engliszaleksandra participationofselectedsolublebmp2andbmp7bonemorphogeneticproteinsandtheirsolubletypeialk1andtypeiibmpr2receptorsinformationanddevelopmentofendometriosis AT wendlochadominika participationofselectedsolublebmp2andbmp7bonemorphogeneticproteinsandtheirsolubletypeialk1andtypeiibmpr2receptorsinformationanddevelopmentofendometriosis AT mielczarekpalaczaleksandra participationofselectedsolublebmp2andbmp7bonemorphogeneticproteinsandtheirsolubletypeialk1andtypeiibmpr2receptorsinformationanddevelopmentofendometriosis |