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The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris
Artemisia capillaris Thunb. (A. capillaris, Yin-Chen in Chinese) is a traditional medicinal herb with a wide spectrum of pharmacological properties ranging from effects against liver dysfunction to treatments of severe cirrhosis and cancer. We used relevant keywords to search electronic databases, i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533588/ https://www.ncbi.nlm.nih.gov/pubmed/34680529 http://dx.doi.org/10.3390/biomedicines9101412 |
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author | Hsueh, Tun-Pin Lin, Wan-Ling Dalley, Jeffrey W. Tsai, Tung-Hu |
author_facet | Hsueh, Tun-Pin Lin, Wan-Ling Dalley, Jeffrey W. Tsai, Tung-Hu |
author_sort | Hsueh, Tun-Pin |
collection | PubMed |
description | Artemisia capillaris Thunb. (A. capillaris, Yin-Chen in Chinese) is a traditional medicinal herb with a wide spectrum of pharmacological properties ranging from effects against liver dysfunction to treatments of severe cirrhosis and cancer. We used relevant keywords to search electronic databases, including PubMed, Medline, and Google Scholar, for scientific contributions related to this medicinal herb and the pharmacokinetics of its components. The pharmaceutical effects of A. capillaris contribute to the treatment not only of viral hepatitis, cirrhosis, and hepatocellular hepatoma, but also metabolic syndrome, psoriasis, and enterovirus in the clinic. The bioactive compounds, including scoparone, capillarisin, scopoletin, and chlorogenic acid, exhibit antioxidant, anti-inflammatory, antisteatotic, antiviral, and antitumor properties, reflecting the pharmacological effects of A. capillaris. The pharmacokinetics of the main bioactive compounds in A. capillaris can achieve a maximum concentration within 1 hour, but only chlorogenic acid has a relatively long half-life. Regarding the use of the A. capillaris herb by health professionals to treat various diseases, the dosing schedule of this herb should be carefully considered to maximize therapeutic outcomes while lessening possible side effects. |
format | Online Article Text |
id | pubmed-8533588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85335882021-10-23 The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris Hsueh, Tun-Pin Lin, Wan-Ling Dalley, Jeffrey W. Tsai, Tung-Hu Biomedicines Review Artemisia capillaris Thunb. (A. capillaris, Yin-Chen in Chinese) is a traditional medicinal herb with a wide spectrum of pharmacological properties ranging from effects against liver dysfunction to treatments of severe cirrhosis and cancer. We used relevant keywords to search electronic databases, including PubMed, Medline, and Google Scholar, for scientific contributions related to this medicinal herb and the pharmacokinetics of its components. The pharmaceutical effects of A. capillaris contribute to the treatment not only of viral hepatitis, cirrhosis, and hepatocellular hepatoma, but also metabolic syndrome, psoriasis, and enterovirus in the clinic. The bioactive compounds, including scoparone, capillarisin, scopoletin, and chlorogenic acid, exhibit antioxidant, anti-inflammatory, antisteatotic, antiviral, and antitumor properties, reflecting the pharmacological effects of A. capillaris. The pharmacokinetics of the main bioactive compounds in A. capillaris can achieve a maximum concentration within 1 hour, but only chlorogenic acid has a relatively long half-life. Regarding the use of the A. capillaris herb by health professionals to treat various diseases, the dosing schedule of this herb should be carefully considered to maximize therapeutic outcomes while lessening possible side effects. MDPI 2021-10-08 /pmc/articles/PMC8533588/ /pubmed/34680529 http://dx.doi.org/10.3390/biomedicines9101412 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hsueh, Tun-Pin Lin, Wan-Ling Dalley, Jeffrey W. Tsai, Tung-Hu The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris |
title | The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris |
title_full | The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris |
title_fullStr | The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris |
title_full_unstemmed | The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris |
title_short | The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris |
title_sort | pharmacological effects and pharmacokinetics of active compounds of artemisia capillaris |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533588/ https://www.ncbi.nlm.nih.gov/pubmed/34680529 http://dx.doi.org/10.3390/biomedicines9101412 |
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