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The Role of Uterine Natural Killer Cells on Recurrent Miscarriage and Recurrent Implantation Failure: From Pathophysiology to Treatment

Uterine natural killer (uNK) cells constitute a unique uterine leucocyte subpopulation facilitating implantation and maintaining pregnancy. Herein, we critically analyze current evidence regarding the role of uNK cells in the events entailed in recurrent implantation failure (RIF) and recurrent misc...

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Autores principales: Sfakianoudis, Konstantinos, Rapani, Anna, Grigoriadis, Sokratis, Pantou, Agni, Maziotis, Evangelos, Kokkini, Georgia, Tsirligkani, Chrysanthi, Bolaris, Stamatis, Nikolettos, Konstantinos, Chronopoulou, Margarita, Pantos, Konstantinos, Simopoulou, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533591/
https://www.ncbi.nlm.nih.gov/pubmed/34680540
http://dx.doi.org/10.3390/biomedicines9101425
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author Sfakianoudis, Konstantinos
Rapani, Anna
Grigoriadis, Sokratis
Pantou, Agni
Maziotis, Evangelos
Kokkini, Georgia
Tsirligkani, Chrysanthi
Bolaris, Stamatis
Nikolettos, Konstantinos
Chronopoulou, Margarita
Pantos, Konstantinos
Simopoulou, Mara
author_facet Sfakianoudis, Konstantinos
Rapani, Anna
Grigoriadis, Sokratis
Pantou, Agni
Maziotis, Evangelos
Kokkini, Georgia
Tsirligkani, Chrysanthi
Bolaris, Stamatis
Nikolettos, Konstantinos
Chronopoulou, Margarita
Pantos, Konstantinos
Simopoulou, Mara
author_sort Sfakianoudis, Konstantinos
collection PubMed
description Uterine natural killer (uNK) cells constitute a unique uterine leucocyte subpopulation facilitating implantation and maintaining pregnancy. Herein, we critically analyze current evidence regarding the role of uNK cells in the events entailed in recurrent implantation failure (RIF) and recurrent miscarriages (RM). Data suggest an association between RIF and RM with abnormally elevated uNK cells’ numbers, as well as with a defective biological activity leading to cytotoxicity. However, other studies do not concur on these associations. Robust data suggesting a definitive causative relationship between uNK cells and RIF and RM is missing. Considering the possibility of uNK cells involvement on RIF and RM pathophysiology, possible treatments including glucocorticoids, intralipids, and intravenous immunoglobulin administration have been proposed towards addressing uNK related RIF and RM. When considering clinical routine practice, this study indicated that solid evidence is required to report on efficiency and safety of these treatments as there are recommendations that clearly advise against their employment. In conclusion, defining a causative relationship between uNK and RIF–RM pathologies certainly merits investigation. Future studies should serve as a prerequisite prior to proposing the use of uNK as a biomarker or prior to targeting uNK cells for therapeutic purposes addressing RIF and RM.
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spelling pubmed-85335912021-10-23 The Role of Uterine Natural Killer Cells on Recurrent Miscarriage and Recurrent Implantation Failure: From Pathophysiology to Treatment Sfakianoudis, Konstantinos Rapani, Anna Grigoriadis, Sokratis Pantou, Agni Maziotis, Evangelos Kokkini, Georgia Tsirligkani, Chrysanthi Bolaris, Stamatis Nikolettos, Konstantinos Chronopoulou, Margarita Pantos, Konstantinos Simopoulou, Mara Biomedicines Review Uterine natural killer (uNK) cells constitute a unique uterine leucocyte subpopulation facilitating implantation and maintaining pregnancy. Herein, we critically analyze current evidence regarding the role of uNK cells in the events entailed in recurrent implantation failure (RIF) and recurrent miscarriages (RM). Data suggest an association between RIF and RM with abnormally elevated uNK cells’ numbers, as well as with a defective biological activity leading to cytotoxicity. However, other studies do not concur on these associations. Robust data suggesting a definitive causative relationship between uNK cells and RIF and RM is missing. Considering the possibility of uNK cells involvement on RIF and RM pathophysiology, possible treatments including glucocorticoids, intralipids, and intravenous immunoglobulin administration have been proposed towards addressing uNK related RIF and RM. When considering clinical routine practice, this study indicated that solid evidence is required to report on efficiency and safety of these treatments as there are recommendations that clearly advise against their employment. In conclusion, defining a causative relationship between uNK and RIF–RM pathologies certainly merits investigation. Future studies should serve as a prerequisite prior to proposing the use of uNK as a biomarker or prior to targeting uNK cells for therapeutic purposes addressing RIF and RM. MDPI 2021-10-09 /pmc/articles/PMC8533591/ /pubmed/34680540 http://dx.doi.org/10.3390/biomedicines9101425 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sfakianoudis, Konstantinos
Rapani, Anna
Grigoriadis, Sokratis
Pantou, Agni
Maziotis, Evangelos
Kokkini, Georgia
Tsirligkani, Chrysanthi
Bolaris, Stamatis
Nikolettos, Konstantinos
Chronopoulou, Margarita
Pantos, Konstantinos
Simopoulou, Mara
The Role of Uterine Natural Killer Cells on Recurrent Miscarriage and Recurrent Implantation Failure: From Pathophysiology to Treatment
title The Role of Uterine Natural Killer Cells on Recurrent Miscarriage and Recurrent Implantation Failure: From Pathophysiology to Treatment
title_full The Role of Uterine Natural Killer Cells on Recurrent Miscarriage and Recurrent Implantation Failure: From Pathophysiology to Treatment
title_fullStr The Role of Uterine Natural Killer Cells on Recurrent Miscarriage and Recurrent Implantation Failure: From Pathophysiology to Treatment
title_full_unstemmed The Role of Uterine Natural Killer Cells on Recurrent Miscarriage and Recurrent Implantation Failure: From Pathophysiology to Treatment
title_short The Role of Uterine Natural Killer Cells on Recurrent Miscarriage and Recurrent Implantation Failure: From Pathophysiology to Treatment
title_sort role of uterine natural killer cells on recurrent miscarriage and recurrent implantation failure: from pathophysiology to treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533591/
https://www.ncbi.nlm.nih.gov/pubmed/34680540
http://dx.doi.org/10.3390/biomedicines9101425
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