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Transcriptomic Characterization of Postmolar Gestational Choriocarcinoma

The human placenta shares properties with solid tumors, such as rapid growth, tissue invasion, cell migration, angiogenesis, and immune evasion. However, the mechanisms that drive the evolution from premalignant proliferative placental diseases—called hydatidiform moles—to their malignant counterpar...

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Autores principales: Collet, Constance, Lopez, Jonathan, Battail, Christophe, Allias, Fabienne, Devouassoux-Shisheboran, Mojgan, Patrier, Sophie, Lemaitre, Nicolas, Hajri, Touria, Massardier, Jérôme, You, Benoit, Mallet, François, Golfier, François, Alfaidy, Nadia, Bolze, Pierre-Adrien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533618/
https://www.ncbi.nlm.nih.gov/pubmed/34680590
http://dx.doi.org/10.3390/biomedicines9101474
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author Collet, Constance
Lopez, Jonathan
Battail, Christophe
Allias, Fabienne
Devouassoux-Shisheboran, Mojgan
Patrier, Sophie
Lemaitre, Nicolas
Hajri, Touria
Massardier, Jérôme
You, Benoit
Mallet, François
Golfier, François
Alfaidy, Nadia
Bolze, Pierre-Adrien
author_facet Collet, Constance
Lopez, Jonathan
Battail, Christophe
Allias, Fabienne
Devouassoux-Shisheboran, Mojgan
Patrier, Sophie
Lemaitre, Nicolas
Hajri, Touria
Massardier, Jérôme
You, Benoit
Mallet, François
Golfier, François
Alfaidy, Nadia
Bolze, Pierre-Adrien
author_sort Collet, Constance
collection PubMed
description The human placenta shares properties with solid tumors, such as rapid growth, tissue invasion, cell migration, angiogenesis, and immune evasion. However, the mechanisms that drive the evolution from premalignant proliferative placental diseases—called hydatidiform moles—to their malignant counterparts, gestational choriocarcinoma, as well as the factors underlying the increased aggressiveness of choriocarcinoma arising after term delivery compared to those developing from hydatidiform moles, are unknown. Using a 730-gene panel covering 13 cancer-associated canonical pathways, we compared the transcriptomic profiles of complete moles to those of postmolar choriocarcinoma samples and those of postmolar to post-term delivery choriocarcinoma. We identified 33 genes differentially expressed between complete moles and postmolar choriocarcinoma, which revealed TGF-β pathway dysregulation. We found the strong expression of SALL4, an upstream regulator of TGF-β, in postmolar choriocarcinoma, compared to moles, in which its expression was almost null. Finally, there were no differentially expressed genes between postmolar and post-term delivery choriocarcinoma samples. To conclude, the TGF-β pathway appears to be a crucial step in the progression of placental malignancies. Further studies should investigate the value of TGF- β family members as biomarkers and new therapeutic targets.
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spelling pubmed-85336182021-10-23 Transcriptomic Characterization of Postmolar Gestational Choriocarcinoma Collet, Constance Lopez, Jonathan Battail, Christophe Allias, Fabienne Devouassoux-Shisheboran, Mojgan Patrier, Sophie Lemaitre, Nicolas Hajri, Touria Massardier, Jérôme You, Benoit Mallet, François Golfier, François Alfaidy, Nadia Bolze, Pierre-Adrien Biomedicines Article The human placenta shares properties with solid tumors, such as rapid growth, tissue invasion, cell migration, angiogenesis, and immune evasion. However, the mechanisms that drive the evolution from premalignant proliferative placental diseases—called hydatidiform moles—to their malignant counterparts, gestational choriocarcinoma, as well as the factors underlying the increased aggressiveness of choriocarcinoma arising after term delivery compared to those developing from hydatidiform moles, are unknown. Using a 730-gene panel covering 13 cancer-associated canonical pathways, we compared the transcriptomic profiles of complete moles to those of postmolar choriocarcinoma samples and those of postmolar to post-term delivery choriocarcinoma. We identified 33 genes differentially expressed between complete moles and postmolar choriocarcinoma, which revealed TGF-β pathway dysregulation. We found the strong expression of SALL4, an upstream regulator of TGF-β, in postmolar choriocarcinoma, compared to moles, in which its expression was almost null. Finally, there were no differentially expressed genes between postmolar and post-term delivery choriocarcinoma samples. To conclude, the TGF-β pathway appears to be a crucial step in the progression of placental malignancies. Further studies should investigate the value of TGF- β family members as biomarkers and new therapeutic targets. MDPI 2021-10-14 /pmc/articles/PMC8533618/ /pubmed/34680590 http://dx.doi.org/10.3390/biomedicines9101474 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Collet, Constance
Lopez, Jonathan
Battail, Christophe
Allias, Fabienne
Devouassoux-Shisheboran, Mojgan
Patrier, Sophie
Lemaitre, Nicolas
Hajri, Touria
Massardier, Jérôme
You, Benoit
Mallet, François
Golfier, François
Alfaidy, Nadia
Bolze, Pierre-Adrien
Transcriptomic Characterization of Postmolar Gestational Choriocarcinoma
title Transcriptomic Characterization of Postmolar Gestational Choriocarcinoma
title_full Transcriptomic Characterization of Postmolar Gestational Choriocarcinoma
title_fullStr Transcriptomic Characterization of Postmolar Gestational Choriocarcinoma
title_full_unstemmed Transcriptomic Characterization of Postmolar Gestational Choriocarcinoma
title_short Transcriptomic Characterization of Postmolar Gestational Choriocarcinoma
title_sort transcriptomic characterization of postmolar gestational choriocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533618/
https://www.ncbi.nlm.nih.gov/pubmed/34680590
http://dx.doi.org/10.3390/biomedicines9101474
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