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Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances
Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hormones, antagonists of orex...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533625/ https://www.ncbi.nlm.nih.gov/pubmed/34680059 http://dx.doi.org/10.3390/biom11101426 |
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author | Gjermeni, Erind Kirstein, Anna S. Kolbig, Florentien Kirchhof, Michael Bundalian, Linnaeus Katzmann, Julius L. Laufs, Ulrich Blüher, Matthias Garten, Antje Le Duc, Diana |
author_facet | Gjermeni, Erind Kirstein, Anna S. Kolbig, Florentien Kirchhof, Michael Bundalian, Linnaeus Katzmann, Julius L. Laufs, Ulrich Blüher, Matthias Garten, Antje Le Duc, Diana |
author_sort | Gjermeni, Erind |
collection | PubMed |
description | Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hormones, antagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat absorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs. We provide insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored. |
format | Online Article Text |
id | pubmed-8533625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85336252021-10-23 Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances Gjermeni, Erind Kirstein, Anna S. Kolbig, Florentien Kirchhof, Michael Bundalian, Linnaeus Katzmann, Julius L. Laufs, Ulrich Blüher, Matthias Garten, Antje Le Duc, Diana Biomolecules Review Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hormones, antagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat absorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs. We provide insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored. MDPI 2021-09-29 /pmc/articles/PMC8533625/ /pubmed/34680059 http://dx.doi.org/10.3390/biom11101426 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gjermeni, Erind Kirstein, Anna S. Kolbig, Florentien Kirchhof, Michael Bundalian, Linnaeus Katzmann, Julius L. Laufs, Ulrich Blüher, Matthias Garten, Antje Le Duc, Diana Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances |
title | Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances |
title_full | Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances |
title_fullStr | Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances |
title_full_unstemmed | Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances |
title_short | Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances |
title_sort | obesity–an update on the basic pathophysiology and review of recent therapeutic advances |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533625/ https://www.ncbi.nlm.nih.gov/pubmed/34680059 http://dx.doi.org/10.3390/biom11101426 |
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