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Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances

Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hormones, antagonists of orex...

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Autores principales: Gjermeni, Erind, Kirstein, Anna S., Kolbig, Florentien, Kirchhof, Michael, Bundalian, Linnaeus, Katzmann, Julius L., Laufs, Ulrich, Blüher, Matthias, Garten, Antje, Le Duc, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533625/
https://www.ncbi.nlm.nih.gov/pubmed/34680059
http://dx.doi.org/10.3390/biom11101426
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author Gjermeni, Erind
Kirstein, Anna S.
Kolbig, Florentien
Kirchhof, Michael
Bundalian, Linnaeus
Katzmann, Julius L.
Laufs, Ulrich
Blüher, Matthias
Garten, Antje
Le Duc, Diana
author_facet Gjermeni, Erind
Kirstein, Anna S.
Kolbig, Florentien
Kirchhof, Michael
Bundalian, Linnaeus
Katzmann, Julius L.
Laufs, Ulrich
Blüher, Matthias
Garten, Antje
Le Duc, Diana
author_sort Gjermeni, Erind
collection PubMed
description Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hormones, antagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat absorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs. We provide insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored.
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spelling pubmed-85336252021-10-23 Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances Gjermeni, Erind Kirstein, Anna S. Kolbig, Florentien Kirchhof, Michael Bundalian, Linnaeus Katzmann, Julius L. Laufs, Ulrich Blüher, Matthias Garten, Antje Le Duc, Diana Biomolecules Review Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hormones, antagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat absorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs. We provide insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored. MDPI 2021-09-29 /pmc/articles/PMC8533625/ /pubmed/34680059 http://dx.doi.org/10.3390/biom11101426 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gjermeni, Erind
Kirstein, Anna S.
Kolbig, Florentien
Kirchhof, Michael
Bundalian, Linnaeus
Katzmann, Julius L.
Laufs, Ulrich
Blüher, Matthias
Garten, Antje
Le Duc, Diana
Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances
title Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances
title_full Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances
title_fullStr Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances
title_full_unstemmed Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances
title_short Obesity–An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances
title_sort obesity–an update on the basic pathophysiology and review of recent therapeutic advances
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533625/
https://www.ncbi.nlm.nih.gov/pubmed/34680059
http://dx.doi.org/10.3390/biom11101426
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