Acute Valproate Exposure Induces Mitochondrial Biogenesis and Autophagy with FOXO3a Modulation in SH-SY5Y Cells

Valproic acid (VPA) is an antiepileptic drug found to induce mitochondrial dysfunction and autophagy in cancer cell lines. We treated the SH-SY5Y cell line with various concentrations of VPA (1, 5, and 10 mM). The treatment decreased cell viability, ATP production, and mitochondrial membrane potenti...

Descripción completa

Detalles Bibliográficos
Autores principales: Jang, Eun-Hye, Lee, Jung-Ho, Kim, Soon-Ae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533738/
https://www.ncbi.nlm.nih.gov/pubmed/34685502
http://dx.doi.org/10.3390/cells10102522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533738/
https://www.ncbi.nlm.nih.gov/pubmed/34685502
http://dx.doi.org/10.3390/cells10102522

Ejemplares similares