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Acute Valproate Exposure Induces Mitochondrial Biogenesis and Autophagy with FOXO3a Modulation in SH-SY5Y Cells

Valproic acid (VPA) is an antiepileptic drug found to induce mitochondrial dysfunction and autophagy in cancer cell lines. We treated the SH-SY5Y cell line with various concentrations of VPA (1, 5, and 10 mM). The treatment decreased cell viability, ATP production, and mitochondrial membrane potenti...

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Detalles Bibliográficos
Autores principales:	Jang, Eun-Hye, Lee, Jung-Ho, Kim, Soon-Ae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533738/ https://www.ncbi.nlm.nih.gov/pubmed/34685502 http://dx.doi.org/10.3390/cells10102522

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