A Promising Intracellular Protein-Degradation Strategy: TRIMbody-Away Technique Based on Nanobody Fragment

Most recently, a technology termed TRIM-Away has allowed acute and rapid destruction of endogenous target proteins in cultured cells using specific antibodies and endogenous/exogenous tripartite motif 21 (TRIM21). However, the relatively large size of the full-size mAbs (150 kDa) results in correspo...

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Detalles Bibliográficos
Autores principales: Chen, Gang, Kong, Yu, Li, You, Huang, Ailing, Wang, Chunyu, Zhou, Shanshan, Yang, Zhenlin, Wu, Yanling, Ren, Jianke, Ying, Tianlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533776/
https://www.ncbi.nlm.nih.gov/pubmed/34680146
http://dx.doi.org/10.3390/biom11101512

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