Brain and Breast Cancer Cells with PTEN Loss of Function Reveal Enhanced Durotaxis and RHOB Dependent Amoeboid Migration Utilizing 3D Scaffolds and Aligned Microfiber Tracts

SIMPLE SUMMARY: Glioblastoma multiforme (GBM) and metastatic triple-negative breast cancer (TNBC) with PTEN mutations are associated with brain tumor spreading and poor patient outcomes. GBM, and possibly TNBC, migrate on axons and blood vessels to disseminate in the brain; however, the mechanism is...

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Detalles Bibliográficos
Autores principales: Wieland, Annalena, Strissel, Pamela L., Schorle, Hannah, Bakirci, Ezgi, Janzen, Dieter, Beckmann, Matthias W., Eckstein, Markus, Dalton, Paul D., Strick, Reiner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533830/
https://www.ncbi.nlm.nih.gov/pubmed/34680293
http://dx.doi.org/10.3390/cancers13205144

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