Cargando…

PROTECT: Prospective Phase-II-Trial Evaluating Adaptive Proton Therapy for Cervical Cancer to Reduce the Impact on Morbidity and the Immune System

SIMPLE SUMMARY: Chemoradiation with photon radiotherapy is very effective as a locally advanced cervical cancer (LACC) treatment. However, the majority of women with LACC experience treatment-related toxicity involving the gastrointestinal and urogenital tracts and the immune system. Compared to tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Corbeau, Anouk, Nout, Remi A., Mens, Jan Willem M., Horeweg, Nanda, Godart, Jérémy, Kerkhof, Ellen M., Kuipers, Sander C., van Poelgeest, Mariette I. E., Kroep, Judith R., Boere, Ingrid A., van Doorn, Helena C., Hoogeman, Mischa S., van der Heide, Uulke A., Putter, Hein, Welters, Marij J. P., van der Burg, Sjoerd H., Creutzberg, Carien L., de Boer, Stephanie M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533850/ https://www.ncbi.nlm.nih.gov/pubmed/34680328 http://dx.doi.org/10.3390/cancers13205179

Ejemplares similares

The impact of bone marrow sparing on organs at risk dose for cervical cancer: a Pareto front analysis
por: Kuipers, Sander, et al.
Publicado: (2023)

Detection and functional assessment of regulatory T cells in clinical samples
por: Santegoets, Saskia, et al.
Publicado: (2014)

Synergy of therapeutic vaccination against HPV16 oncogenic proteins and standard chemotherapeutics
por: Melief, Cornelis J, et al.
Publicado: (2014)

The Tumor Microenvironment and Immunotherapy of Oropharyngeal Squamous Cell Carcinoma
por: Welters, Marij J. P., et al.
Publicado: (2020)

Pre-existing inflammatory immune microenvironment predicts the clinical response of vulvar high-grade squamous intraepithelial lesions to therapeutic HPV16 vaccination
por: Abdulrahman, Ziena, et al.
Publicado: (2020)

High numbers of activated helper T cells are associated with better clinical outcome in early stage vulvar cancer, irrespective of HPV or p53 status
por: Kortekaas, Kim E., et al.
Publicado: (2019)

Monitoring of the Immune Dysfunction in Cancer Patients
por: Santegoets, Saskia J. A. M., et al.
Publicado: (2016)

The combined HPV16-E2/E6/E7 T cell response in oropharyngeal cancer predicts superior survival
por: Santegoets, Saskia J., et al.
Publicado: (2023)

Human Papillary and Reticular Fibroblasts Show Distinct Functions on Tumor Behavior in 3D-Organotypic Cultures Mimicking Melanoma and HNSCC
por: Wu, Shidi, et al.
Publicado: (2022)

The Role of Radiotherapy in Endometrial Cancer: Current Evidence and Trends
por: Creutzberg, Carien L., et al.
Publicado: (2011)

A phase 1/2 study combining gemcitabine, Pegintron and p53 SLP vaccine in patients with platinum-resistant ovarian cancer
por: Dijkgraaf, Eveline M., et al.
Publicado: (2015)

Cell mediated immunity against HPV16 E2, E6 and E7 peptides in women with incident CIN and in constantly HPV-negative women followed-up for 10-years
por: Paaso, Anna, et al.
Publicado: (2015)

Potential use of lymph node-derived HPV-specific T cells for adoptive cell therapy of cervical cancer
por: van Poelgeest, Mariëtte I. E., et al.
Publicado: (2016)

Primary vulvar squamous cell carcinomas with high T cell infiltration and active immune signaling are potential candidates for neoadjuvant PD-1/PD-L1 immunotherapy
por: Kortekaas, Kim E, et al.
Publicado: (2021)

Human papillomavirus 16-specific cell-mediated immunity in children born to mothers with incident cervical intraepithelial neoplasia (CIN) and to those constantly HPV negative
por: Koskimaa, Hanna-Mari, et al.
Publicado: (2015)

Standard radiotherapy but not chemotherapy impairs systemic immunity in non-small cell lung cancer
por: Talebian Yazdi, Mehrdad, et al.
Publicado: (2016)

Adjuvant therapy for endometrial cancer in the era of molecular classification: radiotherapy, chemoradiation and novel targets for therapy
por: van den Heerik, Anne Sophie V M, et al.
Publicado: (2021)

Harmonization of the intracellular cytokine staining assay
por: Welters, Marij J. P., et al.
Publicado: (2012)

Interferon‐γ and IL‐5 associated cell‐mediated immune responses to HPV16 E2 and E6 distinguish between persistent oral HPV16 infections and noninfected mucosa
por: Paaso, Anna, et al.
Publicado: (2021)

A sexual rehabilitation intervention for women with gynaecological cancer receiving radiotherapy (SPARC study): design of a multicentre randomized controlled trial
por: Suvaal, Isabelle, et al.
Publicado: (2021)

Short-Term Fasting Synergizes with Solid Cancer Therapy by Boosting Antitumor Immunity
por: de Gruil, Nadia, et al.
Publicado: (2022)

Human papillomavirus 16 E2-, E6- and E7-specific T-cell responses in children and their mothers who developed incident cervical intraepithelial neoplasia during a 14-year follow-up of the Finnish Family HPV cohort
por: Koskimaa, Hanna-Mari, et al.
Publicado: (2014)

Selecting Adjuvant Treatment for Endometrial Carcinoma Using Molecular Risk Factors
por: Wortman, Bastiaan G., et al.
Publicado: (2019)

A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions
por: de Vos van Steenwijk, Peggy J., et al.
Publicado: (2012)

CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors
por: Duurland, Chantal L, et al.
Publicado: (2022)

EGFR signaling suppresses type 1 cytokine-induced T-cell attracting chemokine secretion in head and neck cancer
por: Ma, Wenbo, et al.
Publicado: (2018)

Adjuvant Systemic Therapy after Chemoradiation and Brachytherapy for Locally Advanced Cervical Cancer: A Systematic Review and Meta-Analysis
por: Horeweg, Nanda, et al.
Publicado: (2021)

Timed adoptive T cell transfer during chemotherapy in patients with recurrent platinum-sensitive epithelial ovarian cancer
por: Verdegaal, Els M E, et al.
Publicado: (2023)

The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study
por: de Groot, Stefanie, et al.
Publicado: (2015)

Imaging for radiation treatment planning and monitoring in prostate Cancer: Precision, personalization, individualization of therapy
por: Grosu, Anca-Ligia, et al.
Publicado: (2019)

Interleukin-6 receptor and its ligand interleukin-6 are opposite markers for survival and infiltration with mature myeloid cells in ovarian cancer
por: Wouters, MCA, et al.
Publicado: (2015)

HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial
por: van Poelgeest, Mariette I E, et al.
Publicado: (2013)

Local and systemic XAGE-1b-specific immunity in patients with lung adenocarcinoma
por: Talebian Yazdi, Mehrdad, et al.
Publicado: (2015)

Impact of (chemo)radiotherapy on immune cell composition and function in cervical cancer patients
por: van Meir, H., et al.
Publicado: (2016)

Hierarchical Modeling for Rare Event Detection and Cell Subset Alignment across Flow Cytometry Samples
por: Cron, Andrew, et al.
Publicado: (2013)

Molecular Classification Predicts Response to Radiotherapy in the Randomized PORTEC-1 and PORTEC-2 Trials for Early-Stage Endometrioid Endometrial Cancer
por: Horeweg, Nanda, et al.
Publicado: (2023)

Quantitative Magnetic Resonance Imaging for Biological Image-Guided Adaptive Radiotherapy
por: van Houdt, Petra J., et al.
Publicado: (2021)

A pre‐existing coordinated inflammatory microenvironment is associated with complete response of vulvar high‐grade squamous intraepithelial lesions to different forms of immunotherapy
por: Abdulrahman, Ziena, et al.
Publicado: (2020)

Managing Multi-center Flow Cytometry Data for Immune Monitoring
por: White, Scott, et al.
Publicado: (2015)

Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study
por: Mandruzzato, Susanna, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_k8h4b4jkv042feft56fcm32jv4