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Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression

Planarians are flatworms capable of whole-body regeneration, able to regrow any missing body part after injury or amputation. The extraordinary regenerative capacity of planarians is based upon the presence in the adult of a large population of somatic pluripotent stem cells. These cells, called neo...

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Detalles Bibliográficos
Autores principales: Molina, M. Dolores, Cebrià, Francesc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533874/
https://www.ncbi.nlm.nih.gov/pubmed/34680165
http://dx.doi.org/10.3390/biom11101532
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author Molina, M. Dolores
Cebrià, Francesc
author_facet Molina, M. Dolores
Cebrià, Francesc
author_sort Molina, M. Dolores
collection PubMed
description Planarians are flatworms capable of whole-body regeneration, able to regrow any missing body part after injury or amputation. The extraordinary regenerative capacity of planarians is based upon the presence in the adult of a large population of somatic pluripotent stem cells. These cells, called neoblasts, offer a unique system to study the process of stem cell specification and differentiation in vivo. In recent years, FACS-based isolation of neoblasts, RNAi functional analyses as well as high-throughput approaches such as single-cell sequencing have allowed a rapid progress in our understanding of many different aspects of neoblast biology. Here, we summarize our current knowledge on the molecular signatures that define planarian neoblasts heterogeneity, which includes a percentage of truly pluripotent stem cells, and guide the commitment of pluripotent neoblasts into lineage-specific progenitor cells, as well as their differentiation into specific planarian cell types.
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spelling pubmed-85338742021-10-23 Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression Molina, M. Dolores Cebrià, Francesc Biomolecules Review Planarians are flatworms capable of whole-body regeneration, able to regrow any missing body part after injury or amputation. The extraordinary regenerative capacity of planarians is based upon the presence in the adult of a large population of somatic pluripotent stem cells. These cells, called neoblasts, offer a unique system to study the process of stem cell specification and differentiation in vivo. In recent years, FACS-based isolation of neoblasts, RNAi functional analyses as well as high-throughput approaches such as single-cell sequencing have allowed a rapid progress in our understanding of many different aspects of neoblast biology. Here, we summarize our current knowledge on the molecular signatures that define planarian neoblasts heterogeneity, which includes a percentage of truly pluripotent stem cells, and guide the commitment of pluripotent neoblasts into lineage-specific progenitor cells, as well as their differentiation into specific planarian cell types. MDPI 2021-10-17 /pmc/articles/PMC8533874/ /pubmed/34680165 http://dx.doi.org/10.3390/biom11101532 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Molina, M. Dolores
Cebrià, Francesc
Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression
title Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression
title_full Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression
title_fullStr Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression
title_full_unstemmed Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression
title_short Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression
title_sort decoding stem cells: an overview on planarian stem cell heterogeneity and lineage progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533874/
https://www.ncbi.nlm.nih.gov/pubmed/34680165
http://dx.doi.org/10.3390/biom11101532
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