Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications

Cancer is one of the most important health problems and the second leading cause of death worldwide. Despite the advances in oncology, cancer heterogeneity remains challenging to therapeutics. This is because the exosome-mediated crosstalk between cancer and non-cancer cells within the tumor microen...

Descripción completa

Detalles Bibliográficos
Autores principales: da Costa, Vitor Rodrigues, Araldi, Rodrigo Pinheiro, Vigerelli, Hugo, D’Ámelio, Fernanda, Mendes, Thais Biude, Gonzaga, Vivian, Policíquio, Bruna, Colozza-Gama, Gabriel Avelar, Valverde, Cristiane Wenceslau, Kerkis, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533895/
https://www.ncbi.nlm.nih.gov/pubmed/34685596
http://dx.doi.org/10.3390/cells10102617
Descripción
Sumario:Cancer is one of the most important health problems and the second leading cause of death worldwide. Despite the advances in oncology, cancer heterogeneity remains challenging to therapeutics. This is because the exosome-mediated crosstalk between cancer and non-cancer cells within the tumor microenvironment (TME) contributes to the acquisition of all hallmarks of cancer and leads to the formation of cancer stem cells (CSCs), which exhibit resistance to a range of anticancer drugs. Thus, this review aims to summarize the role of TME-derived exosomes in cancer biology and explore the clinical potential of mesenchymal stem-cell-derived exosomes as a cancer treatment, discussing future prospects of cell-free therapy for cancer treatment and challenges to be overcome.

Ejemplares similares