Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications

Cancer is one of the most important health problems and the second leading cause of death worldwide. Despite the advances in oncology, cancer heterogeneity remains challenging to therapeutics. This is because the exosome-mediated crosstalk between cancer and non-cancer cells within the tumor microen...

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Autores principales: da Costa, Vitor Rodrigues, Araldi, Rodrigo Pinheiro, Vigerelli, Hugo, D’Ámelio, Fernanda, Mendes, Thais Biude, Gonzaga, Vivian, Policíquio, Bruna, Colozza-Gama, Gabriel Avelar, Valverde, Cristiane Wenceslau, Kerkis, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533895/
https://www.ncbi.nlm.nih.gov/pubmed/34685596
http://dx.doi.org/10.3390/cells10102617
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author da Costa, Vitor Rodrigues
Araldi, Rodrigo Pinheiro
Vigerelli, Hugo
D’Ámelio, Fernanda
Mendes, Thais Biude
Gonzaga, Vivian
Policíquio, Bruna
Colozza-Gama, Gabriel Avelar
Valverde, Cristiane Wenceslau
Kerkis, Irina
author_facet da Costa, Vitor Rodrigues
Araldi, Rodrigo Pinheiro
Vigerelli, Hugo
D’Ámelio, Fernanda
Mendes, Thais Biude
Gonzaga, Vivian
Policíquio, Bruna
Colozza-Gama, Gabriel Avelar
Valverde, Cristiane Wenceslau
Kerkis, Irina
author_sort da Costa, Vitor Rodrigues
collection PubMed
description Cancer is one of the most important health problems and the second leading cause of death worldwide. Despite the advances in oncology, cancer heterogeneity remains challenging to therapeutics. This is because the exosome-mediated crosstalk between cancer and non-cancer cells within the tumor microenvironment (TME) contributes to the acquisition of all hallmarks of cancer and leads to the formation of cancer stem cells (CSCs), which exhibit resistance to a range of anticancer drugs. Thus, this review aims to summarize the role of TME-derived exosomes in cancer biology and explore the clinical potential of mesenchymal stem-cell-derived exosomes as a cancer treatment, discussing future prospects of cell-free therapy for cancer treatment and challenges to be overcome.
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spelling pubmed-85338952021-10-23 Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications da Costa, Vitor Rodrigues Araldi, Rodrigo Pinheiro Vigerelli, Hugo D’Ámelio, Fernanda Mendes, Thais Biude Gonzaga, Vivian Policíquio, Bruna Colozza-Gama, Gabriel Avelar Valverde, Cristiane Wenceslau Kerkis, Irina Cells Review Cancer is one of the most important health problems and the second leading cause of death worldwide. Despite the advances in oncology, cancer heterogeneity remains challenging to therapeutics. This is because the exosome-mediated crosstalk between cancer and non-cancer cells within the tumor microenvironment (TME) contributes to the acquisition of all hallmarks of cancer and leads to the formation of cancer stem cells (CSCs), which exhibit resistance to a range of anticancer drugs. Thus, this review aims to summarize the role of TME-derived exosomes in cancer biology and explore the clinical potential of mesenchymal stem-cell-derived exosomes as a cancer treatment, discussing future prospects of cell-free therapy for cancer treatment and challenges to be overcome. MDPI 2021-10-01 /pmc/articles/PMC8533895/ /pubmed/34685596 http://dx.doi.org/10.3390/cells10102617 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
da Costa, Vitor Rodrigues
Araldi, Rodrigo Pinheiro
Vigerelli, Hugo
D’Ámelio, Fernanda
Mendes, Thais Biude
Gonzaga, Vivian
Policíquio, Bruna
Colozza-Gama, Gabriel Avelar
Valverde, Cristiane Wenceslau
Kerkis, Irina
Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications
title Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications
title_full Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications
title_fullStr Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications
title_full_unstemmed Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications
title_short Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications
title_sort exosomes in the tumor microenvironment: from biology to clinical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533895/
https://www.ncbi.nlm.nih.gov/pubmed/34685596
http://dx.doi.org/10.3390/cells10102617
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