Pulmonary Nodule and Mass: Superiority of MRI of Diffusion-Weighted Imaging and T2-Weighted Imaging to FDG-PET/CT

SIMPLE SUMMARY: Although diffusion-weighted imaging (DWI) can be valuable for differential diagnosis of lung cancer from benign pulmonary nodules and masses (PNMs), the diagnostic capability may not be perfect. This study’s purpose was to compare the diagnostic efficacy of 18-fluoro-2-deoxy-glucose positron emission tomography–computed tomography (FDG-PET/CT) and magnetic resonance imaging (MRI) of DWI and T2-weighted imaging (T2WI) in PNMs. There were 278 lung cancers and 50 benign PNMs that were examined by FDG-PET/CT and MRI. The sensitivity of the maximum standardized uptake value (SUVmax) was significantly lower than that of the apparent diffusion coefficient (ADC) and the T2 contrast ratio (T2 CR). The accuracy of SUVmax was significantly lower than that of ADC and that of T2 CR. The sensitivity and accuracy of MRI were significantly higher than those of FDG-PET/CT. MRI can replace FDG-PET/CT for differential diagnosis of PNMs. ABSTRACT: The purpose of this retrospective study was to compare the diagnostic efficacy of FDG-PET/CT and MRI in discriminating malignant from benign pulmonary nodules and masses (PNMs). There were 278 lung cancers and 50 benign PNMs that were examined by FDG-PET/CT and MRI. The T2 contrast ratio (T2 CR) was designated as the ratio of T2 signal intensity of PNM divided by T2 signal intensity of the rhomboid muscle. The optimal cut-off values (OCVs) for differential diagnosis were 3.605 for maximum standardized uptake value (SUVmax), 1.459 × 10(−3) mm(2)/s for apparent diffusion coefficient (ADC), and 2.46 for T2 CR. Areas under the receiver operating characteristics curves were 67.5% for SUVmax, 74.3% for ADC, and 72.4% for T2 CR, respectively. The sensitivity (0.658) of SUVmax was significantly lower than that (0.838) of ADC (p < 0.001) and that (0.871) of T2 CR (p < 0.001). The specificity (0.620) of SUVmax was that the same as (0.640) ADC and (0.640) of T2 CR. The accuracy (0.652) of SUVmax was significantly lower than that (0.808) of ADC (p < 0.001) and that (0.835) of T2 CR (p < 0.001). The sensitivity and accuracy of DWI and T2WI in MRI were significantly higher than those of FDG-PET/CT. Ultimately, MRI can replace FDG PET/CT for differential diagnosis of PNMs saving healthcare systems money while not sacrificing the quality of care.