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Hospital Variation in Cancer Treatments and Survival OutComes of Advanced Melanoma Patients: Nationwide Quality Assurance in The Netherlands
SIMPLE SUMMARY: The survival of advanced melanoma patients has improved significantly over the last decade due to the introduction of new systemic therapies. It is unknown whether survival outcomes of advanced melanoma patients differ between melanoma centers in the Netherlands. This research aimed...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533953/ https://www.ncbi.nlm.nih.gov/pubmed/34680228 http://dx.doi.org/10.3390/cancers13205077 |
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author | van Breeschoten, Jesper van den Eertwegh, Alfonsus J. M. de Wreede, Liesbeth C. Hilarius, Doranne L. van Zwet, Erik W. Haanen, John B. Blank, Christian U. Aarts, Maureen J. B. van den Berkmortel, Franchette W. P. J. de Groot, Jan Willem B. Hospers, Geke A. P. Kapiteijn, Ellen Piersma, Djura van Rijn, Rozemarijn S. Stevense-den Boer, Marion A. M. van der Veldt, Astrid A. M. Vreugdenhil, Gerard Boers-Sonderen, Marye J. Suijkerbuijk, Karijn P. M. Wouters, Michel W. J. M. |
author_facet | van Breeschoten, Jesper van den Eertwegh, Alfonsus J. M. de Wreede, Liesbeth C. Hilarius, Doranne L. van Zwet, Erik W. Haanen, John B. Blank, Christian U. Aarts, Maureen J. B. van den Berkmortel, Franchette W. P. J. de Groot, Jan Willem B. Hospers, Geke A. P. Kapiteijn, Ellen Piersma, Djura van Rijn, Rozemarijn S. Stevense-den Boer, Marion A. M. van der Veldt, Astrid A. M. Vreugdenhil, Gerard Boers-Sonderen, Marye J. Suijkerbuijk, Karijn P. M. Wouters, Michel W. J. M. |
author_sort | van Breeschoten, Jesper |
collection | PubMed |
description | SIMPLE SUMMARY: The survival of advanced melanoma patients has improved significantly over the last decade due to the introduction of new systemic therapies. It is unknown whether survival outcomes of advanced melanoma patients differ between melanoma centers in the Netherlands. This research aimed to assess center variation in treatments and 2-year survival probabilities of advanced melanoma patients diagnosed between 2013 and 2017 in the Netherlands. Significant center variation in 2-year survival probabilities of patients diagnosed in 2014–2015 was observed after correcting for case-mix and treatment with new systemic therapies. The different use of new systemic therapies partially explained the observed variation. From 2016 onwards, no significant difference in 2-year survival was observed between centers. This study shows the added value of quality monitoring with a national registry that enables the study of variation between centers. ABSTRACT: Background: To assure a high quality of care for patients treated in Dutch melanoma centers, hospital variation in treatment patterns and outcomes is evaluated in the Dutch Melanoma Treatment Registry. The aim of this study was to assess center variation in treatments and 2-year survival probabilities of patients diagnosed between 2013 and 2017 in the Netherlands. Methods: We selected patients diagnosed between 2013 and 2017 with unresectable IIIC or stage IV melanoma, registered in the Dutch Melanoma Treatment Registry. Centers’ performance on 2-year survival was evaluated using Empirical Bayes estimates calculated in a random effects model. Treatment patterns of the centers with the lowest and highest estimates for 2-year survival were compared. Results: For patients diagnosed between 2014 and 2015, significant center variation in 2-year survival probabilities was observed even after correcting for case-mix and treatment with new systemic therapies. The different use of new systemic therapies partially explained the observed variation. From 2016 onwards, no significant difference in 2-year survival was observed between centers. Conclusion: Our data suggest that between 2014 and 2015, after correcting for patient case-mix, significant variation in 2-year survival probabilities between Dutch melanoma centers existed. The use of new systemic therapies could partially explain this variation. In 2013 and between 2016 and 2017, no significant variation between centers existed. |
format | Online Article Text |
id | pubmed-8533953 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85339532021-10-23 Hospital Variation in Cancer Treatments and Survival OutComes of Advanced Melanoma Patients: Nationwide Quality Assurance in The Netherlands van Breeschoten, Jesper van den Eertwegh, Alfonsus J. M. de Wreede, Liesbeth C. Hilarius, Doranne L. van Zwet, Erik W. Haanen, John B. Blank, Christian U. Aarts, Maureen J. B. van den Berkmortel, Franchette W. P. J. de Groot, Jan Willem B. Hospers, Geke A. P. Kapiteijn, Ellen Piersma, Djura van Rijn, Rozemarijn S. Stevense-den Boer, Marion A. M. van der Veldt, Astrid A. M. Vreugdenhil, Gerard Boers-Sonderen, Marye J. Suijkerbuijk, Karijn P. M. Wouters, Michel W. J. M. Cancers (Basel) Article SIMPLE SUMMARY: The survival of advanced melanoma patients has improved significantly over the last decade due to the introduction of new systemic therapies. It is unknown whether survival outcomes of advanced melanoma patients differ between melanoma centers in the Netherlands. This research aimed to assess center variation in treatments and 2-year survival probabilities of advanced melanoma patients diagnosed between 2013 and 2017 in the Netherlands. Significant center variation in 2-year survival probabilities of patients diagnosed in 2014–2015 was observed after correcting for case-mix and treatment with new systemic therapies. The different use of new systemic therapies partially explained the observed variation. From 2016 onwards, no significant difference in 2-year survival was observed between centers. This study shows the added value of quality monitoring with a national registry that enables the study of variation between centers. ABSTRACT: Background: To assure a high quality of care for patients treated in Dutch melanoma centers, hospital variation in treatment patterns and outcomes is evaluated in the Dutch Melanoma Treatment Registry. The aim of this study was to assess center variation in treatments and 2-year survival probabilities of patients diagnosed between 2013 and 2017 in the Netherlands. Methods: We selected patients diagnosed between 2013 and 2017 with unresectable IIIC or stage IV melanoma, registered in the Dutch Melanoma Treatment Registry. Centers’ performance on 2-year survival was evaluated using Empirical Bayes estimates calculated in a random effects model. Treatment patterns of the centers with the lowest and highest estimates for 2-year survival were compared. Results: For patients diagnosed between 2014 and 2015, significant center variation in 2-year survival probabilities was observed even after correcting for case-mix and treatment with new systemic therapies. The different use of new systemic therapies partially explained the observed variation. From 2016 onwards, no significant difference in 2-year survival was observed between centers. Conclusion: Our data suggest that between 2014 and 2015, after correcting for patient case-mix, significant variation in 2-year survival probabilities between Dutch melanoma centers existed. The use of new systemic therapies could partially explain this variation. In 2013 and between 2016 and 2017, no significant variation between centers existed. MDPI 2021-10-11 /pmc/articles/PMC8533953/ /pubmed/34680228 http://dx.doi.org/10.3390/cancers13205077 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article van Breeschoten, Jesper van den Eertwegh, Alfonsus J. M. de Wreede, Liesbeth C. Hilarius, Doranne L. van Zwet, Erik W. Haanen, John B. Blank, Christian U. Aarts, Maureen J. B. van den Berkmortel, Franchette W. P. J. de Groot, Jan Willem B. Hospers, Geke A. P. Kapiteijn, Ellen Piersma, Djura van Rijn, Rozemarijn S. Stevense-den Boer, Marion A. M. van der Veldt, Astrid A. M. Vreugdenhil, Gerard Boers-Sonderen, Marye J. Suijkerbuijk, Karijn P. M. Wouters, Michel W. J. M. Hospital Variation in Cancer Treatments and Survival OutComes of Advanced Melanoma Patients: Nationwide Quality Assurance in The Netherlands |
title | Hospital Variation in Cancer Treatments and Survival OutComes of Advanced Melanoma Patients: Nationwide Quality Assurance in The Netherlands |
title_full | Hospital Variation in Cancer Treatments and Survival OutComes of Advanced Melanoma Patients: Nationwide Quality Assurance in The Netherlands |
title_fullStr | Hospital Variation in Cancer Treatments and Survival OutComes of Advanced Melanoma Patients: Nationwide Quality Assurance in The Netherlands |
title_full_unstemmed | Hospital Variation in Cancer Treatments and Survival OutComes of Advanced Melanoma Patients: Nationwide Quality Assurance in The Netherlands |
title_short | Hospital Variation in Cancer Treatments and Survival OutComes of Advanced Melanoma Patients: Nationwide Quality Assurance in The Netherlands |
title_sort | hospital variation in cancer treatments and survival outcomes of advanced melanoma patients: nationwide quality assurance in the netherlands |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533953/ https://www.ncbi.nlm.nih.gov/pubmed/34680228 http://dx.doi.org/10.3390/cancers13205077 |
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