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Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets
SIMPLE SUMMARY: Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers whose causation is only partly understood. An increasing number of studies have uncovered molecular changes associated with pNETs, helping to identify common disease mechanisms. This knowledge has guided current pNET...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533967/ https://www.ncbi.nlm.nih.gov/pubmed/34680266 http://dx.doi.org/10.3390/cancers13205117 |
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author | Maharjan, Chandra K. Ear, Po Hien Tran, Catherine G. Howe, James R. Chandrasekharan, Chandrikha Quelle, Dawn E. |
author_facet | Maharjan, Chandra K. Ear, Po Hien Tran, Catherine G. Howe, James R. Chandrasekharan, Chandrikha Quelle, Dawn E. |
author_sort | Maharjan, Chandra K. |
collection | PubMed |
description | SIMPLE SUMMARY: Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers whose causation is only partly understood. An increasing number of studies have uncovered molecular changes associated with pNETs, helping to identify common disease mechanisms. This knowledge has guided current pNET therapies that can effectively slow progression of the disease. However, tumors often become resistant to available therapies, necessitating a deeper understanding of mechanisms driving disease progression in order to develop new treatments. Here, we provide a comprehensive review of pNET-associated molecular alterations and existing pNET models to illustrate potential areas for advancement in research and therapy. ABSTRACT: Pancreatic neuroendocrine tumors (pNETs) are unique, slow-growing malignancies whose molecular pathogenesis is incompletely understood. With rising incidence of pNETs over the last four decades, larger and more comprehensive ‘omic’ analyses of patient tumors have led to a clearer picture of the pNET genomic landscape and transcriptional profiles for both primary and metastatic lesions. In pNET patients with advanced disease, those insights have guided the use of targeted therapies that inhibit activated mTOR and receptor tyrosine kinase (RTK) pathways or stimulate somatostatin receptor signaling. Such treatments have significantly benefited patients, but intrinsic or acquired drug resistance in the tumors remains a major problem that leaves few to no effective treatment options for advanced cases. This demands a better understanding of essential molecular and biological events underlying pNET growth, metastasis, and drug resistance. This review examines the known molecular alterations associated with pNET pathogenesis, identifying which changes may be drivers of the disease and, as such, relevant therapeutic targets. We also highlight areas that warrant further investigation at the biological level and discuss available model systems for pNET research. The paucity of pNET models has hampered research efforts over the years, although recently developed cell line, animal, patient-derived xenograft, and patient-derived organoid models have significantly expanded the available platforms for pNET investigations. Advancements in pNET research and understanding are expected to guide improved patient treatments. |
format | Online Article Text |
id | pubmed-8533967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85339672021-10-23 Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets Maharjan, Chandra K. Ear, Po Hien Tran, Catherine G. Howe, James R. Chandrasekharan, Chandrikha Quelle, Dawn E. Cancers (Basel) Review SIMPLE SUMMARY: Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers whose causation is only partly understood. An increasing number of studies have uncovered molecular changes associated with pNETs, helping to identify common disease mechanisms. This knowledge has guided current pNET therapies that can effectively slow progression of the disease. However, tumors often become resistant to available therapies, necessitating a deeper understanding of mechanisms driving disease progression in order to develop new treatments. Here, we provide a comprehensive review of pNET-associated molecular alterations and existing pNET models to illustrate potential areas for advancement in research and therapy. ABSTRACT: Pancreatic neuroendocrine tumors (pNETs) are unique, slow-growing malignancies whose molecular pathogenesis is incompletely understood. With rising incidence of pNETs over the last four decades, larger and more comprehensive ‘omic’ analyses of patient tumors have led to a clearer picture of the pNET genomic landscape and transcriptional profiles for both primary and metastatic lesions. In pNET patients with advanced disease, those insights have guided the use of targeted therapies that inhibit activated mTOR and receptor tyrosine kinase (RTK) pathways or stimulate somatostatin receptor signaling. Such treatments have significantly benefited patients, but intrinsic or acquired drug resistance in the tumors remains a major problem that leaves few to no effective treatment options for advanced cases. This demands a better understanding of essential molecular and biological events underlying pNET growth, metastasis, and drug resistance. This review examines the known molecular alterations associated with pNET pathogenesis, identifying which changes may be drivers of the disease and, as such, relevant therapeutic targets. We also highlight areas that warrant further investigation at the biological level and discuss available model systems for pNET research. The paucity of pNET models has hampered research efforts over the years, although recently developed cell line, animal, patient-derived xenograft, and patient-derived organoid models have significantly expanded the available platforms for pNET investigations. Advancements in pNET research and understanding are expected to guide improved patient treatments. MDPI 2021-10-12 /pmc/articles/PMC8533967/ /pubmed/34680266 http://dx.doi.org/10.3390/cancers13205117 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Maharjan, Chandra K. Ear, Po Hien Tran, Catherine G. Howe, James R. Chandrasekharan, Chandrikha Quelle, Dawn E. Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets |
title | Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets |
title_full | Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets |
title_fullStr | Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets |
title_full_unstemmed | Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets |
title_short | Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets |
title_sort | pancreatic neuroendocrine tumors: molecular mechanisms and therapeutic targets |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533967/ https://www.ncbi.nlm.nih.gov/pubmed/34680266 http://dx.doi.org/10.3390/cancers13205117 |
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