The Chemokine-Based Peptide, CXCL9(74-103), Inhibits Angiogenesis by Blocking Heparan Sulfate Proteoglycan-Mediated Signaling of Multiple Endothelial Growth Factors

SIMPLE SUMMARY: Major angiogenic growth factors activate downstream signaling cascades by interacting with both receptor tyrosine kinases (RTKs) and cell surface proteoglycans, such as heparan sulfate proteoglycans (HSPGs). As current anti-angiogenesis regimens in cancer are often faced with resista...

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Detalles Bibliográficos
Autores principales: De Zutter, Alexandra, Crijns, Helena, Berghmans, Nele, García-Caballero, Melissa, Vanbrabant, Lotte, Pörtner, Noëmie, Vanheule, Vincent, Verscheure, Paulien, Siddiquei, Mohammad Mairaj, Abu El-Asrar, Ahmed M., Carmeliet, Peter, Van Wielendaele, Pieter, De Meester, Ingrid, Van Damme, Jo, Proost, Paul, Struyf, Sofie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534003/
https://www.ncbi.nlm.nih.gov/pubmed/34680238
http://dx.doi.org/10.3390/cancers13205090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534003/
https://www.ncbi.nlm.nih.gov/pubmed/34680238
http://dx.doi.org/10.3390/cancers13205090

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