Cargando…

Obesity and Pancreatic Cancer: Insight into Mechanisms

SIMPLE SUMMARY: Obesity is recognized as a chronic progressive disease and risk factor for many human diseases. The high and increasing number of obese people may underlie the expected increase in pancreatic cancer cases in the United States. There are several pathways discussed that link obesity wi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eibl, Guido, Rozengurt, Enrique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534007/ https://www.ncbi.nlm.nih.gov/pubmed/34680216 http://dx.doi.org/10.3390/cancers13205067

Ejemplares similares

Crosstalk between KRAS, SRC and YAP Signaling in Pancreatic Cancer: Interactions Leading to Aggressive Disease and Drug Resistance
por: Rozengurt, Enrique, et al.
Publicado: (2021)

Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development
por: Rozengurt, Enrique, et al.
Publicado: (2019)

Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival
por: Rozengurt, Enrique, et al.
Publicado: (2018)

Pancreatic Macrophages: Critical Players in Obesity-Promoted Pancreatic Cancer
por: Teper, Yaroslav, et al.
Publicado: (2020)

Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
por: Sinnett-Smith, James, et al.
Publicado: (2022)

Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells
por: Ming, Ming, et al.
Publicado: (2014)

Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice
por: Teper, Yaroslav, et al.
Publicado: (2023)

Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in Kras(G12D) mice
por: Hao, Fang, et al.
Publicado: (2019)

Statins Inhibit Inflammatory Cytokine Production by Macrophages and Acinar-to-Ductal Metaplasia of Pancreatic Cells
por: Ako, Soichiro, et al.
Publicado: (2022)

Obesity-Induced Adipose Tissue Inflammation as a Strong Promotional Factor for Pancreatic Ductal Adenocarcinoma
por: Chang, Hui-Hua, et al.
Publicado: (2019)

Risk factors for pancreatic cancer: underlying mechanisms and potential targets
por: Edderkaoui, Mouad, et al.
Publicado: (2014)

Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model
por: Chang, Hui-Hua, et al.
Publicado: (2018)

The Role of PPAR-γ and Its Interaction with COX-2 in Pancreatic Cancer
por: Eibl, Guido
Publicado: (2008)

Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice
por: Xu, Mu, et al.
Publicado: (2018)

Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells
por: Rozengurt, Enrique
Publicado: (2014)

Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer
por: Duffy, John P, et al.
Publicado: (2003)

The Diverse Involvement of Cigarette Smoking in Pancreatic Cancer Development and Prognosis
por: Weissman, Simcha, et al.
Publicado: (2020)

Pancreatic Cancer and Cachexia—Metabolic Mechanisms and Novel Insights
por: Poulia, Kalliopi Anna, et al.
Publicado: (2020)

Different Patterns of Akt and ERK Feedback Activation in Response to Rapamycin, Active-Site mTOR Inhibitors and Metformin in Pancreatic Cancer Cells
por: Soares, Heloisa P., et al.
Publicado: (2013)

Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice
por: Kaur, Kawaljit, et al.
Publicado: (2018)

Pancreatic Cancer and Obesity: Molecular Mechanisms of Cell Transformation and Chemoresistance
por: Cascetta, Priscilla, et al.
Publicado: (2018)

Obesity and Pancreatic Cancer: Recent Progress in Epidemiology, Mechanisms and Bariatric Surgery
por: Shinoda, Shuhei, et al.
Publicado: (2022)

OA04.02. Mechanisms of growth inhibition of pancreatic cancer by omega-3 polyunsaturated fatty acids
por: Chen, M, et al.
Publicado: (2012)

Suppression of Gingival NK Cells in Precancerous and Cancerous Stages of Pancreatic Cancer in KC and BLT-Humanized Mice
por: Kaur, Kawaljit, et al.
Publicado: (2017)

Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice
por: Chang, Hui-Hua, et al.
Publicado: (2017)

The Impact of obesity and diabetes mellitus on pancreatic cancer: Molecular mechanisms and clinical perspectives
por: Quoc Lam, Bao, et al.
Publicado: (2020)

Bioluminescence Imaging of Angiogenesis in a Murine Orthotopic Pancreatic Cancer Model
por: Angst, Eliane, et al.
Publicado: (2010)

Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer
por: Andersen, Dana K., et al.
Publicado: (2017)

Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin
por: Zhou, Guisheng, et al.
Publicado: (2014)

Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California
por: Juo, Yen-Yi, et al.
Publicado: (2018)

New insights into the mechanism of low high-density lipoprotein cholesterol in obesity
por: Wang, Hao, et al.
Publicado: (2011)

Protein Kinase D: A Selective Target for Antigen Receptors and a Downstream Target for Protein Kinase C in Lymphocytes
por: Matthews, Sharon A., et al.
Publicado: (2000)

Pancreatic cancer genomics: insights and opportunities for clinical translation
por: Makohon-Moore, Alvin, et al.
Publicado: (2013)

Novel Insights in the Physiopathology and Management of Obesity-Related Kidney Disease
por: Sandino, Justo, et al.
Publicado: (2022)

The SUMO pathway in pancreatic cancer: insights and inhibition
por: Schneeweis, Christian, et al.
Publicado: (2020)

Molecular Mechanism of Pancreatic Stellate Cells Activation in Chronic Pancreatitis and Pancreatic Cancer
por: Jin, Guihua, et al.
Publicado: (2020)

Current Insights into the Potential Role of fMRI in Discovering the Mechanisms Underlying Obesity
por: Szmygin, Hanna, et al.
Publicado: (2023)

Adipogenesis Regulation and Endocrine Disruptors: Emerging Insights in Obesity
por: González-Casanova, Jorge Enrique, et al.
Publicado: (2020)

Mechanistic Insights into the Link between Obesity and Prostate Cancer
por: Adesunloye, Bamidele A.
Publicado: (2021)

Linking Obesity with Colorectal Cancer: Epidemiology and Mechanistic Insights
por: Ye, Pengfei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_64qb8o6pnsb175727jv773nroi