Cargando…

Alternative Pre-mRNA Splicing of the Mu Opioid Receptor Gene, OPRM1: Insight into Complex Mu Opioid Actions

Most opioid analgesics used clinically, including morphine and fentanyl, as well as the recreational drug heroin, act primarily through the mu opioid receptor, a class A Rhodopsin-like G protein-coupled receptor (GPCR). The single-copy mu opioid receptor gene, OPRM1, undergoes extensive alternative...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Shan, Kang, Wen-Jia, Abrimian, Anna, Xu, Jin, Cartegni, Luca, Majumdar, Susruta, Hesketh, Patrick, Bekker, Alex, Pan, Ying-Xian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534031/ https://www.ncbi.nlm.nih.gov/pubmed/34680158 http://dx.doi.org/10.3390/biom11101525

Ejemplares similares

Exploring Pharmacological Functions of Alternatively Spliced Variants of the Mu Opioid Receptor Gene, Oprm1, via Gene-Targeted Animal Models
por: Kang, Wenjian, et al.
Publicado: (2022)

Endogenous Opioid Peptides and Alternatively Spliced Mu Opioid Receptor Seven Transmembrane Carboxyl-Terminal Variants
por: Abrimian, Anna, et al.
Publicado: (2021)

Characterizing exons 11 and 1 promoters of the mu opioid receptor (Oprm) gene in transgenic mice
por: Xu, Jin, et al.
Publicado: (2006)

Identification and characterization of seven new exon 11-associated splice variants of the rat mu opioid receptor gene, OPRM1
por: Xu, Jin, et al.
Publicado: (2011)

Haplotype block structure of the genomic region of the mu opioid receptor gene (OPRM1)
por: Levran, Orna, et al.
Publicado: (2010)

Variation of the human mu-opioid receptor (OPRM1) gene predicts vulnerability to frustration
por: Daniel, Alan M., et al.
Publicado: (2020)

Functional Polymorphism of the Mu-Opioid Receptor Gene (OPRM1) Influences Reinforcement Learning in Humans
por: Lee, Mary R., et al.
Publicado: (2011)

A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism
por: Gris, Pavel, et al.
Publicado: (2010)

Mu Opioid Receptor Actions in the Lateral Habenula
por: Margolis, Elyssa B., et al.
Publicado: (2016)

Mu opioid receptor (OPRM1) as a predictor of treatment outcome in opiate-dependent individuals of Arab descent
por: AL-Eitan, Laith N, et al.
Publicado: (2012)

Lack of association between the A118G polymorphism of the mu opioid receptor gene (OPRM1) and opioid dependence: A meta-analysis
por: Coller, Janet K, et al.
Publicado: (2009)

Association of opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with nicotine dependence
por: Kong, Xiangyi, et al.
Publicado: (2017)

Variation in the Mu-Opioid Receptor (OPRM1) and Offspring Sex Are Associated With Maternal Behavior in Rhesus Macaques (Macaca mulatta)
por: Wood, Elizabeth K., et al.
Publicado: (2022)

Mu Opioid Splice Variant MOR-1K Contributes to the Development of Opioid-Induced Hyperalgesia
por: Oladosu, Folabomi A., et al.
Publicado: (2015)

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonists
por: Murányi, Marianna, et al.
Publicado: (2013)

Nitro-benzylideneoxymorphone, a bifunctional mu and delta opioid receptor ligand with high mu opioid receptor efficacy
por: Olson, Keith M., et al.
Publicado: (2023)

Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians
por: Ehlers, Cindy L, et al.
Publicado: (2008)

An analysis of the effect of mu-opioid receptor gene (OPRM1) promoter region DNA methylation on the response of naltrexone treatment of alcohol dependence
por: Lin, Yufei, et al.
Publicado: (2020)

Activity of opioid ligands in cells expressing cloned mu opioid receptors
por: Gharagozlou, Parham, et al.
Publicado: (2003)

Mu Opioid Receptor Gene: New Point Mutations in Opioid Addicts
por: Dinarvand, Amin, et al.
Publicado: (2014)

Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D(2) Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor
por: Vasudevan, Lakshmi, et al.
Publicado: (2019)

An Emerging Role for the Delta Opioid Receptor in the Regulation of Mu Opioid Receptor Function
por: Rozenfeld, Raphael, et al.
Publicado: (2007)

DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion
por: Chidambaran, Vidya, et al.
Publicado: (2017)

Mu opioid receptor: from pain to glucose metabolism
por: Tudurí, Eva, et al.
Publicado: (2016)

Biased Opioid Ligands
por: Faouzi, Abdelfattah, et al.
Publicado: (2020)

Comparison of physicochemical properties and biological activities of opioid morphinans interacting with mu opioid receptors
por: Asim, Muhammad F, et al.
Publicado: (2008)

Role of kappa‐opioid and mu‐opioid receptors in pruritus: Peripheral and central itch circuits
por: Kim, Brian S., et al.
Publicado: (2022)

Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons
por: Quirion, Béatrice, et al.
Publicado: (2022)

Differential Expressions of the Alternatively Spliced Variant mRNAs of the µ Opioid Receptor Gene, OPRM1, in Brain Regions of Four Inbred Mouse Strains
por: Xu, Jin, et al.
Publicado: (2014)

Anatomical Analysis of Transient Potential Vanilloid Receptor 1 (Trpv1+) and Mu-Opioid Receptor (Oprm1+) Co-expression in Rat Dorsal Root Ganglion Neurons
por: Ma, Wenting, et al.
Publicado: (2022)

Naloxegol: First oral peripherally acting mu opioid receptor antagonists for opioid-induced constipation
por: Anantharamu, Tejus, et al.
Publicado: (2015)

Mu opioid receptors on vGluT2‐expressing glutamatergic neurons modulate opioid reward
por: Reeves, Kaitlin C., et al.
Publicado: (2020)

Interactions Between Opioids and Dextroamphetamine on Locomotor Activity: Influence of an Opioid's Relative Efficacy at the Mu Receptor
por: Smith, Mark A., et al.
Publicado: (2022)

Mechanism of opioid addiction and its intervention therapy: Focusing on the reward circuitry and mu‐opioid receptor
por: Zhang, Jia‐Jia, et al.
Publicado: (2022)

Opioids, sleep, analgesia and respiratory depression: Their convergence on Mu (μ)-opioid receptors in the parabrachial area
por: Lynch, Nicole, et al.
Publicado: (2023)

Orvinols with Mixed Kappa/Mu Opioid Receptor Agonist Activity
por: Greedy, Benjamin M., et al.
Publicado: (2013)

Differential Stability of the Crystallographic Interfaces of Mu- and Kappa-Opioid Receptors
por: Johnston, Jennifer M., et al.
Publicado: (2014)

Anhedonia to music and mu-opioids: Evidence from the administration of naltrexone
por: Mallik, Adiel, et al.
Publicado: (2017)

Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons
por: Ehrlich, Aliza T., et al.
Publicado: (2019)

Heteromerization Modulates mu Opioid Receptor Functional Properties in vivo
por: Ugur, Muzeyyen, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_go1e4hds3o7509aahlifnb0dqv