The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers

Genetic analysis of the association between alcohol, cocaine, and opiate addiction and variable number tandem repeat (VNTR) polymorphisms in monoamine oxidase B (MAOB) and serotonergic 5-hydroxytryptamine (serotonin) receptor 1B and 2C (HTR1B 21 and HTR2C) pathway genes was performed in a sample of...

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Autores principales: Mateu, César, Rodríguez-Arias, Marta, Gil-Miravet, Isis, Benito, Ana, Tomás, José M., Haro, Gonzalo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534042/
https://www.ncbi.nlm.nih.gov/pubmed/34679329
http://dx.doi.org/10.3390/brainsci11101265
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author Mateu, César
Rodríguez-Arias, Marta
Gil-Miravet, Isis
Benito, Ana
Tomás, José M.
Haro, Gonzalo
author_facet Mateu, César
Rodríguez-Arias, Marta
Gil-Miravet, Isis
Benito, Ana
Tomás, José M.
Haro, Gonzalo
author_sort Mateu, César
collection PubMed
description Genetic analysis of the association between alcohol, cocaine, and opiate addiction and variable number tandem repeat (VNTR) polymorphisms in monoamine oxidase B (MAOB) and serotonergic 5-hydroxytryptamine (serotonin) receptor 1B and 2C (HTR1B 21 and HTR2C) pathway genes was performed in a sample of 302 polyconsumers. Our genetic association analysis revealed a significant association between a 184 base pair (bp) VNTR polymorphism in the MAOB gene and addiction to cocaine and opiates. This work highlights new genetic marker associations in cocaine and opiate polyconsumer addictions. These data help to clarify and quantify the complex role of genetics in addictive disorders, as well as their future contribution to the prevention (genetic counselling), diagnosis (genetic diagnosis of vulnerability), and treatment (pharmacogenomics) of these disorders.
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spelling pubmed-85340422021-10-23 The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers Mateu, César Rodríguez-Arias, Marta Gil-Miravet, Isis Benito, Ana Tomás, José M. Haro, Gonzalo Brain Sci Article Genetic analysis of the association between alcohol, cocaine, and opiate addiction and variable number tandem repeat (VNTR) polymorphisms in monoamine oxidase B (MAOB) and serotonergic 5-hydroxytryptamine (serotonin) receptor 1B and 2C (HTR1B 21 and HTR2C) pathway genes was performed in a sample of 302 polyconsumers. Our genetic association analysis revealed a significant association between a 184 base pair (bp) VNTR polymorphism in the MAOB gene and addiction to cocaine and opiates. This work highlights new genetic marker associations in cocaine and opiate polyconsumer addictions. These data help to clarify and quantify the complex role of genetics in addictive disorders, as well as their future contribution to the prevention (genetic counselling), diagnosis (genetic diagnosis of vulnerability), and treatment (pharmacogenomics) of these disorders. MDPI 2021-09-24 /pmc/articles/PMC8534042/ /pubmed/34679329 http://dx.doi.org/10.3390/brainsci11101265 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mateu, César
Rodríguez-Arias, Marta
Gil-Miravet, Isis
Benito, Ana
Tomás, José M.
Haro, Gonzalo
The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers
title The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers
title_full The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers
title_fullStr The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers
title_full_unstemmed The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers
title_short The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers
title_sort association between a maob variable number tandem repeat polymorphism and cocaine and opiate addictions in polyconsumers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534042/
https://www.ncbi.nlm.nih.gov/pubmed/34679329
http://dx.doi.org/10.3390/brainsci11101265
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