Cargando…

Semi-Mechanistic Model for the Antitumor Response of a Combination Cocktail of Immuno-Modulators in Non-Inflamed (Cold) Tumors

SIMPLE SUMMARY: The clinical efficacy of immunotherapies when treating cold tumors is still low, and different treatment combinations are needed when dealing with this challenging scenario. In this work, a middle-out strategy was followed to develop a model describing the antitumor efficacy of diffe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sancho-Araiz, Aymara, Zalba, Sara, Garrido, María J., Berraondo, Pedro, Topp, Brian, de Alwis, Dinesh, Parra-Guillen, Zinnia P., Mangas-Sanjuan, Víctor, Trocóniz, Iñaki F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534053/ https://www.ncbi.nlm.nih.gov/pubmed/34680196 http://dx.doi.org/10.3390/cancers13205049

Ejemplares similares

Mechanistic characterization of oscillatory patterns in unperturbed tumor growth dynamics: The interplay between cancer cells and components of tumor microenvironment
por: Sancho-Araiz, Aymara, et al.
Publicado: (2023)

The Role of Mathematical Models in Immuno-Oncology: Challenges and Future Perspectives
por: Sancho-Araiz, Aymara, et al.
Publicado: (2021)

Mechanistic Modeling of a Novel Oncolytic Virus, V937, to Describe Viral Kinetic and Dynamic Processes Following Intratumoral and Intravenous Administration
por: Parra-Guillen, Zinnia P., et al.
Publicado: (2021)

Modulation of intratumoural myeloid cells, the hallmark of the anti-tumour efficacy induced by a triple combination: tumour-associated peptide, TLR-3 ligand and α-PD-1
por: Zalba, Sara, et al.
Publicado: (2021)

Kinetic and Dynamic Computational Model-Based Characterization of New Proteins in Mice: Application to Interferon Alpha Linked to Apolipoprotein A-I
por: Parra-Guillen, Zinnia Patricia, et al.
Publicado: (2012)

Mechanistic modelling of enzyme‐restoration effects of new recombinant liver‐targeted proteins in acute intermittent porphyria
por: Vera‐Yunca, Diego, et al.
Publicado: (2022)

Editorial: Innovative pharmacometric approaches to inform drug development and clinical use
por: Garcia-Cremades, Maria, et al.
Publicado: (2023)

A physiologically based pharmacokinetic model for V937 oncolytic virus in mice
por: Peribañez-Dominguez, Sara, et al.
Publicado: (2023)

Population Pharmacodynamic Modelling of the CD19+ Suppression Effects of Rituximab in Paediatric Patients with Neurological and Autoimmune Diseases
por: Riva, Natalia, et al.
Publicado: (2023)

Machine Learning Analysis of Individual Tumor Lesions in Four Metastatic Colorectal Cancer Clinical Studies: Linking Tumor Heterogeneity to Overall Survival
por: Vera-Yunca, Diego, et al.
Publicado: (2020)

Semi-Mechanistic Pharmacokinetic Model to Guide the Dose Selection of Nimotuzumab in Patients with Autosomal Dominant Polycystic Kidney Disease
por: de Castro-Suárez, Niurys, et al.
Publicado: (2020)

Dual activity of PD-L1 targeted Doxorubicin immunoliposomes promoted an enhanced efficacy of the antitumor immune response in melanoma murine model
por: Merino, María, et al.
Publicado: (2021)

Interferon-Induced Transmembrane Protein 3 Shapes an Inflamed Tumor Microenvironment and Identifies Immuno-Hot Tumors
por: Cai, Yun, et al.
Publicado: (2021)

A quantitative systems pharmacology model for acute viral hepatitis B
por: Asín-Prieto, Eduardo, et al.
Publicado: (2021)

Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies
por: Soto, Elena, et al.
Publicado: (2010)

Semi-dynamic Control of FCM Initialization for Automatic Extraction of Inflamed Appendix from Ultrasonography
por: Kim, Kwang Baek, et al.
Publicado: (2019)

Experience with health care integration in Bidasoa integrated health organisation: development of the continuity of care unit/Experiencia de integración en la Organización Sanitaria Integrada Bidasoa: desarrollo de la Unidad de Continuidad Asistencial
por: Zabalegui, Iñaki Berraondo
Publicado: (2012)

Quantitative Mechanistic Modeling in Support of Pharmacological Therapeutics Development in Immuno-Oncology
por: Peskov, Kirill, et al.
Publicado: (2019)

Efficacy of celecoxib add-on treatment for immuno-metabolic depression: Protocol of the INFLAMED double-blind placebo-controlled randomized controlled trial
por: Zwiep, J.C., et al.
Publicado: (2022)

Mechanistic Multiscale Pharmacokinetic Model for the Anticancer Drug 2’,2’‐difluorodeoxycytidine (Gemcitabine) in Pancreatic Cancer
por: Garcia‐Cremades, Maria, et al.
Publicado: (2020)

Approximate Bayesian inference in semi-mechanistic models
por: Aderhold, Andrej, et al.
Publicado: (2016)

Inflamed Eyes
por: Knaggs, R. Lawford
Publicado: (1894)

Inflamed Dentine
por: Smith, Henry A.
Publicado: (1857)

Inflamed Eyelids
Publicado: (1891)

Inflamed Eyelids
Publicado: (1891)

A Semi-automated Approach to Preparing Antibody Cocktails for Immunophenotypic Analysis of Human Peripheral Blood
por: Koguchi, Yoshinobu, et al.
Publicado: (2016)

Correlation between anti-PD-L1 tumor concentrations and tumor-specific and nonspecific biomarkers in a melanoma mouse model
por: Contreras, Ana M., et al.
Publicado: (2016)

Phage ImmunoPrecipitation Sequencing (PhIP-Seq): The Promise of High Throughput Serology
por: Tiu, Charles Kevin, et al.
Publicado: (2022)

The Microbiota Profile in Inflamed and Non-Inflamed Ileal Pouch–Anal Anastomosis
por: Kousgaard, Sabrina Just, et al.
Publicado: (2020)

Differences between inflamed and non inflamed appendices diagnosed as acute appendicitis
por: Luiz do Nascimento Junior, Pedro, et al.
Publicado: (2021)

Commentary on Pharmacometrics for Immunotherapy
por: Garrido, MJ, et al.
Publicado: (2017)

CORRIGENDUM: Commentary on Pharmacometrics for Immunotherapy
por: Garrido, MJ, et al.
Publicado: (2017)

TcellInflamedDetector: an R package to distinguish T cell inflamed tumor types from non–T cell inflamed tumor types
por: Yang, San-Duk, et al.
Publicado: (2022)

Cocktail Investing
por: Versace, Christopher
Publicado: (2016)

The Apelinergic System Immuno-Detection in the Abomasum and Duodenum of Sheep Grazing on Semi-Natural Pasture
por: Palmioli, Elisa, et al.
Publicado: (2021)

Single-cell Analysis Technologies for Immuno-oncology Research: from Mechanistic Delineation to Biomarker Discovery
por: Bai, Zhiliang, et al.
Publicado: (2021)

The benefits of inflamed arteries
por: Leslie, Mitch
Publicado: (2008)

Smoking Inflames Joints
por: Susman, E
Publicado: (2002)

Inflaming the Brain with Iron
por: Urrutia, Pamela J., et al.
Publicado: (2021)

THE HEART WILL ALSO BE INFLAMED
por: Maaliki, Naji, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mru9m3i9uprg3k3im39n92lvke