Cargando…

Lipid Profiling of Alzheimer’s Disease Brain Highlights Enrichment in Glycerol(phospho)lipid, and Sphingolipid Metabolism

Alzheimer’s disease (AD) is reported to be closely linked with abnormal lipid metabolism. To gain a more comprehensive understanding of what causes AD and its subsequent development, we profiled the lipidome of postmortem (PM) human brains (neocortex) of people with a range of AD pathology (Braak 0–...

Descripción completa

Detalles Bibliográficos
Autores principales:	Akyol, Sumeyya, Ugur, Zafer, Yilmaz, Ali, Ustun, Ilyas, Gorti, Santosh Kapil Kumar, Oh, Kyungjoon, McGuinness, Bernadette, Passmore, Peter, Kehoe, Patrick G., Maddens, Michael E., Green, Brian D., Graham, Stewart F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534054/ https://www.ncbi.nlm.nih.gov/pubmed/34685570 http://dx.doi.org/10.3390/cells10102591

Ejemplares similares

Metabolic Profiling of CSF from People Suffering from Sporadic and LRRK2 Parkinson’s Disease: A Pilot Study
por: Yilmaz, Ali, et al.
Publicado: (2020)

Targeted Metabolic Profiling of Urine Highlights a Potential Biomarker Panel for the Diagnosis of Alzheimer’s Disease and Mild Cognitive Impairment: A Pilot Study
por: Yilmaz, Ali, et al.
Publicado: (2020)

Association of Metabolomic Biomarkers with Sleeve Gastrectomy Weight Loss Outcomes
por: Miller, Wendy M., et al.
Publicado: (2023)

Lipids and lipoproteins may play a role in the neuropathology of Alzheimer’s disease
por: Akyol, Omer, et al.
Publicado: (2023)

Role of circulating sphingolipids in lipid metabolism: Why dietary lipids matter
por: Calzada, Catherine, et al.
Publicado: (2023)

The Biochemical Profile of Post-Mortem Brain from People Who Suffered from Epilepsy Reveals Novel Insights into the Etiopathogenesis of the Disease
por: Lalwani, Ashna M., et al.
Publicado: (2020)

15-Multifaceted impact of caffeic acid phenethyl ester (CAPE) in experimental myocardial injuries
por: Akyol, Sümeyya, et al.
Publicado: (2015)

Metformin induces lipid changes on sphingolipid species and oxidized lipids in polycystic ovary syndrome women
por: Pradas, Irene, et al.
Publicado: (2019)

Sphingolipids and Epoxidized Lipid Metabolites in the Control of Gut Immunosurveillance and Allergy
por: Kunisawa, Jun, et al.
Publicado: (2016)

Lipid Rafts, Sphingolipids, and Ergosterol in Yeast Vacuole Fusion and Maturation
por: Hurst, Logan R., et al.
Publicado: (2020)

Cholesterol and Sphingolipid Enriched Lipid Rafts as Therapeutic Targets in Cancer
por: Codini, Michela, et al.
Publicado: (2021)

Living alone for people on dementia medication: related use of drugs
por: Zafeiridi, Evi, et al.
Publicado: (2020)

Factors influencing transition to care homes for people with dementia in Northern Ireland
por: Zafeiridi, Evi, et al.
Publicado: (2021)

Dementia with Lewy bodies post-mortem brains reveal differentially methylated CpG sites with biomarker potential
por: Shao, Xiaojian, et al.
Publicado: (2022)

Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity
por: Montoliu, Ivan, et al.
Publicado: (2014)

Nitrosopumilus as main source of isoprenoid glycerol dialkyl glycerol tetraether lipids in the central Baltic Sea
por: Wittenborn, Anna Katharina, et al.
Publicado: (2023)

Bone resorption, matrix metalloproteinases and caffeic acid phenethyl ester
por: Akyol, Sumeyya, et al.
Publicado: (2016)

Evidence That Parietal Lobe Fatty Acids May Be More Profoundly Affected in Moderate Alzheimer’s Disease (AD) Pathology Than in Severe AD Pathology
por: Nasaruddin, Muhammad L., et al.
Publicado: (2018)

Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors
por: Kharel, Yugesh, et al.
Publicado: (2018)

The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated
por: Bazarganipour, Sarah, et al.
Publicado: (2019)

The consumption of propolis and royal jelly in preventing upper respiratory tract infections and as dietary supplementation in children
por: Yuksel, Sevda, et al.
Publicado: (2016)

Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations
por: Demirkan, Ayşe, et al.
Publicado: (2012)

Chasing the Major Sphingolipids on Earth: Automated Annotation of Plant Glycosyl Inositol Phospho Ceramides by Glycolipidomics
por: Panzenboeck, Lisa, et al.
Publicado: (2020)

Platelet Membrane β-Secretase Activity in Mild Cognitive Impairment and Conversion to Dementia: a Longitudinal Study
por: McGuinness, Bernadette, et al.
Publicado: (2015)

Factors Associated with Mortality Including Nursing Home Transitions: A Retrospective Analysis of 25,418 People Prescribed Anti-Dementia Drugs in Northern Ireland
por: McMichael, Alan J., et al.
Publicado: (2020)

F24. OMEGA-6 PUFA METABOLISM DISTURBED IN PHOSPHO- AND SPHINGOLIPIDS IN NEUROLEPTIC-NAïVE FIRST-EPISODE SCHIZOPHRENIA PATIENTS – A FATTY ACID PROFILING STUDY IN FIVE LIPID FRACTIONS
por: Langbein, Kerstin, et al.
Publicado: (2018)

Sphingolipid Synthesis Inhibition by Myriocin Administration Enhances Lipid Consumption and Ameliorates Lipid Response to Myocardial Ischemia Reperfusion Injury
por: Bonezzi, Fabiola, et al.
Publicado: (2019)

Caulobacter lipid A is conditionally dispensable in the absence of fur and in the presence of anionic sphingolipids
por: Zik, Justin J., et al.
Publicado: (2022)

Predicting conversion to dementia in a memory clinic: A standard clinical approach compared with an empirically defined clustering method (latent profile analysis) for mild cognitive impairment subtyping
por: McGuinness, Bernadette, et al.
Publicado: (2015)

Methylated Cytochrome P450 and the Solute Carrier Family of Genes Correlate With Perturbations in Bile Acid Metabolism in Parkinson’s Disease
por: Vishweswaraiah, Sangeetha, et al.
Publicado: (2022)

Untargeted Metabolomic Analysis of Human Plasma Indicates Differentially Affected Polyamine and L-Arginine Metabolism in Mild Cognitive Impairment Subjects Converting to Alzheimer’s Disease
por: Graham, Stewart F., et al.
Publicado: (2015)

Metabolomic Profiling of Bile Acids in Clinical and Experimental Samples of Alzheimer’s Disease
por: Pan, Xiaobei, et al.
Publicado: (2017)

The origins and implications of glycerol ether lipids in China coastal wetland sediments
por: Lü, Xiaoxia, et al.
Publicado: (2019)

Antiviral properties of caffeic acid phenethyl ester and its potential application
por: Erdemli, Hacı Kemal, et al.
Publicado: (2015)

In vitro and in vivo neuroprotective effect of caffeic acid phenethyl ester
por: Akyol, Sumeyya, et al.
Publicado: (2015)

Dementia
por: Cunningham, EL, et al.
Publicado: (2015)

A world of sphingolipids and glycolipids in the brain —Novel functions of simple lipids modified with glucose—
por: HIRABAYASHI, Yoshio
Publicado: (2012)

Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease
por: Doccini, Stefano, et al.
Publicado: (2022)

Editorial: Highlights in Lipids in Cardiovascular Disease: 2021
por: Boucheniata, Chaymae, et al.
Publicado: (2022)

Can propolis and caffeic acid phenethyl ester be promising agents against cyclophosphamide toxicity?
por: Akyol, Sumeyya, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_6ttcjeeokhe7qvofetc2roqln8