The Intersection of Purine and Mitochondrial Metabolism in Cancer
Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macro...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534091/ https://www.ncbi.nlm.nih.gov/pubmed/34685583 http://dx.doi.org/10.3390/cells10102603 |
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author | De Vitto, Humberto Arachchige, Danushka B. Richardson, Brian C. French, Jarrod B. |
author_facet | De Vitto, Humberto Arachchige, Danushka B. Richardson, Brian C. French, Jarrod B. |
author_sort | De Vitto, Humberto |
collection | PubMed |
description | Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macromolecules such as purines and pyrimidines. In this review, we highlight the role of purine and mitochondrial metabolism in cancer and how their intersection influences cancer progression, especially in ovarian cancer. Additionally, we address the importance of metabolic rewiring in cancer and how the evolving landscape of purine synthesis and mitochondria inhibitors can be potentially exploited for cancer treatment. |
format | Online Article Text |
id | pubmed-8534091 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85340912021-10-23 The Intersection of Purine and Mitochondrial Metabolism in Cancer De Vitto, Humberto Arachchige, Danushka B. Richardson, Brian C. French, Jarrod B. Cells Review Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macromolecules such as purines and pyrimidines. In this review, we highlight the role of purine and mitochondrial metabolism in cancer and how their intersection influences cancer progression, especially in ovarian cancer. Additionally, we address the importance of metabolic rewiring in cancer and how the evolving landscape of purine synthesis and mitochondria inhibitors can be potentially exploited for cancer treatment. MDPI 2021-09-30 /pmc/articles/PMC8534091/ /pubmed/34685583 http://dx.doi.org/10.3390/cells10102603 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review De Vitto, Humberto Arachchige, Danushka B. Richardson, Brian C. French, Jarrod B. The Intersection of Purine and Mitochondrial Metabolism in Cancer |
title | The Intersection of Purine and Mitochondrial Metabolism in Cancer |
title_full | The Intersection of Purine and Mitochondrial Metabolism in Cancer |
title_fullStr | The Intersection of Purine and Mitochondrial Metabolism in Cancer |
title_full_unstemmed | The Intersection of Purine and Mitochondrial Metabolism in Cancer |
title_short | The Intersection of Purine and Mitochondrial Metabolism in Cancer |
title_sort | intersection of purine and mitochondrial metabolism in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534091/ https://www.ncbi.nlm.nih.gov/pubmed/34685583 http://dx.doi.org/10.3390/cells10102603 |
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