The Intersection of Purine and Mitochondrial Metabolism in Cancer

Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macro...

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Autores principales: De Vitto, Humberto, Arachchige, Danushka B., Richardson, Brian C., French, Jarrod B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534091/
https://www.ncbi.nlm.nih.gov/pubmed/34685583
http://dx.doi.org/10.3390/cells10102603
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author De Vitto, Humberto
Arachchige, Danushka B.
Richardson, Brian C.
French, Jarrod B.
author_facet De Vitto, Humberto
Arachchige, Danushka B.
Richardson, Brian C.
French, Jarrod B.
author_sort De Vitto, Humberto
collection PubMed
description Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macromolecules such as purines and pyrimidines. In this review, we highlight the role of purine and mitochondrial metabolism in cancer and how their intersection influences cancer progression, especially in ovarian cancer. Additionally, we address the importance of metabolic rewiring in cancer and how the evolving landscape of purine synthesis and mitochondria inhibitors can be potentially exploited for cancer treatment.
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spelling pubmed-85340912021-10-23 The Intersection of Purine and Mitochondrial Metabolism in Cancer De Vitto, Humberto Arachchige, Danushka B. Richardson, Brian C. French, Jarrod B. Cells Review Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of intermediates necessary for biosynthesis of macromolecules such as purines and pyrimidines. In this review, we highlight the role of purine and mitochondrial metabolism in cancer and how their intersection influences cancer progression, especially in ovarian cancer. Additionally, we address the importance of metabolic rewiring in cancer and how the evolving landscape of purine synthesis and mitochondria inhibitors can be potentially exploited for cancer treatment. MDPI 2021-09-30 /pmc/articles/PMC8534091/ /pubmed/34685583 http://dx.doi.org/10.3390/cells10102603 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
De Vitto, Humberto
Arachchige, Danushka B.
Richardson, Brian C.
French, Jarrod B.
The Intersection of Purine and Mitochondrial Metabolism in Cancer
title The Intersection of Purine and Mitochondrial Metabolism in Cancer
title_full The Intersection of Purine and Mitochondrial Metabolism in Cancer
title_fullStr The Intersection of Purine and Mitochondrial Metabolism in Cancer
title_full_unstemmed The Intersection of Purine and Mitochondrial Metabolism in Cancer
title_short The Intersection of Purine and Mitochondrial Metabolism in Cancer
title_sort intersection of purine and mitochondrial metabolism in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534091/
https://www.ncbi.nlm.nih.gov/pubmed/34685583
http://dx.doi.org/10.3390/cells10102603
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