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Early Effects of HTLV-1 Infection on the Activation, Exhaustion, and Differentiation of T-Cells in Humanized NSG Mice

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy of CD4(+) T-cells associated with HTLV-1 infection. In this study, we used the model of immunodeficient NSG mice reconstituted with a functional human immune system (HIS) to investigate early events in HTLV-1 pathogenesis. Upon infect...

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Detalles Bibliográficos
Autores principales:	Espíndola, Otávio de Melo, Siteur-van Rijnstra, Esther, Frankin, Esmay, Weijer, Kees, van der Velden, Yme Ubeles, Berkhout, Ben, Blom, Bianca, Villaudy, Julien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534134/ https://www.ncbi.nlm.nih.gov/pubmed/34685494 http://dx.doi.org/10.3390/cells10102514

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