Replacement of Lost Substance P Reduces Fibrosis in the Diabetic Heart by Preventing Adverse Fibroblast and Macrophage Phenotype Changes

Reduced levels of the sensory nerve neuropeptide substance P (SP) have been reported in the diabetic rat heart, the consequence being a loss of cardioprotection in response to ischemic post-conditioning. We considered whether this loss of SP also predisposes the heart to non-ischemic diabetic cardio...

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Autores principales: Widiapradja, Alexander, Kasparian, Ainsley O., McCaffrey, Samuel L., Kolb, Lauren L., Imig, John D., Lacey, Jessica L., Melendez, Giselle C., Levick, Scott P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534147/
https://www.ncbi.nlm.nih.gov/pubmed/34685639
http://dx.doi.org/10.3390/cells10102659

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