The HPSE Gene Insulator—A Novel Regulatory Element That Affects Heparanase Expression, Stem Cell Mobilization, and the Risk of Acute Graft versus Host Disease

The HPSE gene encodes heparanase (HPSE), a key player in cancer, inflammation, and autoimmunity. We have previously identified a strong HPSE gene enhancer involved in self-regulation of heparanase by negative feedback exerted in a functional rs4693608 single-nucleotide polymorphism (SNP) dependent m...

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Detalles Bibliográficos
Autores principales: Ostrovsky, Olga, Baryakh, Polina, Morgulis, Yan, Mayorov, Margarita, Bloom, Nira, Beider, Katia, Shimoni, Avichai, Vlodavsky, Israel, Nagler, Arnon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534152/
https://www.ncbi.nlm.nih.gov/pubmed/34685503
http://dx.doi.org/10.3390/cells10102523

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