Cargando…
Accelerated Early Progression of Amyotrophic Lateral Sclerosis over the COVID-19 Pandemic
During the COVID-19 pandemic and the related lockdowns, outpatient follow-up visits for patients with chronic neurological diseases have been suspended. Managing people affected by amyotrophic lateral sclerosis (ALS) has become highly complicated, leaving patients without the standard multidisciplin...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534200/ https://www.ncbi.nlm.nih.gov/pubmed/34679356 http://dx.doi.org/10.3390/brainsci11101291 |
_version_ | 1784587498247159808 |
---|---|
author | De Marchi, Fabiola Gallo, Chiara Sarnelli, Maria Francesca De Marchi, Ilaria Saraceno, Massimo Cantello, Roberto Mazzini, Letizia |
author_facet | De Marchi, Fabiola Gallo, Chiara Sarnelli, Maria Francesca De Marchi, Ilaria Saraceno, Massimo Cantello, Roberto Mazzini, Letizia |
author_sort | De Marchi, Fabiola |
collection | PubMed |
description | During the COVID-19 pandemic and the related lockdowns, outpatient follow-up visits for patients with chronic neurological diseases have been suspended. Managing people affected by amyotrophic lateral sclerosis (ALS) has become highly complicated, leaving patients without the standard multidisciplinary follow-up. This study aimed to analyze the impact of the COVID-19 lockdown on ALS disease progression. We compared the clinical data and progression in the first year following diagnosis for patients who received ALS diagnosis during 2020 (G20, N = 34), comparing it with a group of diagnosed in 2018 (G18, N = 31). Both groups received a comparable multidisciplinary model of care in our Tertiary Expert ALS Centre, Novara, Italy. The monthly rate of ALSFRS-R decline during the lockdown was significantly increased in G20 compared to G18 (1.52 ± 2.69 vs. 0.76 ± 0.56; p-value: 0.005). In G20, 47% required non-invasive ventilation (vs. 32% of G18). Similarly, in G20, 35% of patients died vs. 19% of patients in G18 (p-value: 0.01). All results were corrected for gender, age, site of onset, and diagnostic delay. Several factors can be implicated in making ALS more severe, with a faster progression, such as reduced medical evaluations and the possibility of therapeutic changes, social isolation, and rehabilitation therapy suspension. |
format | Online Article Text |
id | pubmed-8534200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85342002021-10-23 Accelerated Early Progression of Amyotrophic Lateral Sclerosis over the COVID-19 Pandemic De Marchi, Fabiola Gallo, Chiara Sarnelli, Maria Francesca De Marchi, Ilaria Saraceno, Massimo Cantello, Roberto Mazzini, Letizia Brain Sci Article During the COVID-19 pandemic and the related lockdowns, outpatient follow-up visits for patients with chronic neurological diseases have been suspended. Managing people affected by amyotrophic lateral sclerosis (ALS) has become highly complicated, leaving patients without the standard multidisciplinary follow-up. This study aimed to analyze the impact of the COVID-19 lockdown on ALS disease progression. We compared the clinical data and progression in the first year following diagnosis for patients who received ALS diagnosis during 2020 (G20, N = 34), comparing it with a group of diagnosed in 2018 (G18, N = 31). Both groups received a comparable multidisciplinary model of care in our Tertiary Expert ALS Centre, Novara, Italy. The monthly rate of ALSFRS-R decline during the lockdown was significantly increased in G20 compared to G18 (1.52 ± 2.69 vs. 0.76 ± 0.56; p-value: 0.005). In G20, 47% required non-invasive ventilation (vs. 32% of G18). Similarly, in G20, 35% of patients died vs. 19% of patients in G18 (p-value: 0.01). All results were corrected for gender, age, site of onset, and diagnostic delay. Several factors can be implicated in making ALS more severe, with a faster progression, such as reduced medical evaluations and the possibility of therapeutic changes, social isolation, and rehabilitation therapy suspension. MDPI 2021-09-29 /pmc/articles/PMC8534200/ /pubmed/34679356 http://dx.doi.org/10.3390/brainsci11101291 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article De Marchi, Fabiola Gallo, Chiara Sarnelli, Maria Francesca De Marchi, Ilaria Saraceno, Massimo Cantello, Roberto Mazzini, Letizia Accelerated Early Progression of Amyotrophic Lateral Sclerosis over the COVID-19 Pandemic |
title | Accelerated Early Progression of Amyotrophic Lateral Sclerosis over the COVID-19 Pandemic |
title_full | Accelerated Early Progression of Amyotrophic Lateral Sclerosis over the COVID-19 Pandemic |
title_fullStr | Accelerated Early Progression of Amyotrophic Lateral Sclerosis over the COVID-19 Pandemic |
title_full_unstemmed | Accelerated Early Progression of Amyotrophic Lateral Sclerosis over the COVID-19 Pandemic |
title_short | Accelerated Early Progression of Amyotrophic Lateral Sclerosis over the COVID-19 Pandemic |
title_sort | accelerated early progression of amyotrophic lateral sclerosis over the covid-19 pandemic |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534200/ https://www.ncbi.nlm.nih.gov/pubmed/34679356 http://dx.doi.org/10.3390/brainsci11101291 |
work_keys_str_mv | AT demarchifabiola acceleratedearlyprogressionofamyotrophiclateralsclerosisoverthecovid19pandemic AT gallochiara acceleratedearlyprogressionofamyotrophiclateralsclerosisoverthecovid19pandemic AT sarnellimariafrancesca acceleratedearlyprogressionofamyotrophiclateralsclerosisoverthecovid19pandemic AT demarchiilaria acceleratedearlyprogressionofamyotrophiclateralsclerosisoverthecovid19pandemic AT saracenomassimo acceleratedearlyprogressionofamyotrophiclateralsclerosisoverthecovid19pandemic AT cantelloroberto acceleratedearlyprogressionofamyotrophiclateralsclerosisoverthecovid19pandemic AT mazziniletizia acceleratedearlyprogressionofamyotrophiclateralsclerosisoverthecovid19pandemic |