SEA and GATOR 10 Years Later

The SEA complex was described for the first time in yeast Saccharomyces cerevisiae ten years ago, and its human homologue GATOR complex two years later. During the past decade, many advances on the SEA/GATOR biology in different organisms have been made that allowed its role as an essential upstream...

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Autores principales: Loissell-Baltazar, Yahir A., Dokudovskaya, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534245/
https://www.ncbi.nlm.nih.gov/pubmed/34685669
http://dx.doi.org/10.3390/cells10102689
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author Loissell-Baltazar, Yahir A.
Dokudovskaya, Svetlana
author_facet Loissell-Baltazar, Yahir A.
Dokudovskaya, Svetlana
author_sort Loissell-Baltazar, Yahir A.
collection PubMed
description The SEA complex was described for the first time in yeast Saccharomyces cerevisiae ten years ago, and its human homologue GATOR complex two years later. During the past decade, many advances on the SEA/GATOR biology in different organisms have been made that allowed its role as an essential upstream regulator of the mTORC1 pathway to be defined. In this review, we describe these advances in relation to the identification of multiple functions of the SEA/GATOR complex in nutrient response and beyond and highlight the consequence of GATOR mutations in cancer and neurodegenerative diseases.
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spelling pubmed-85342452021-10-23 SEA and GATOR 10 Years Later Loissell-Baltazar, Yahir A. Dokudovskaya, Svetlana Cells Review The SEA complex was described for the first time in yeast Saccharomyces cerevisiae ten years ago, and its human homologue GATOR complex two years later. During the past decade, many advances on the SEA/GATOR biology in different organisms have been made that allowed its role as an essential upstream regulator of the mTORC1 pathway to be defined. In this review, we describe these advances in relation to the identification of multiple functions of the SEA/GATOR complex in nutrient response and beyond and highlight the consequence of GATOR mutations in cancer and neurodegenerative diseases. MDPI 2021-10-08 /pmc/articles/PMC8534245/ /pubmed/34685669 http://dx.doi.org/10.3390/cells10102689 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Loissell-Baltazar, Yahir A.
Dokudovskaya, Svetlana
SEA and GATOR 10 Years Later
title SEA and GATOR 10 Years Later
title_full SEA and GATOR 10 Years Later
title_fullStr SEA and GATOR 10 Years Later
title_full_unstemmed SEA and GATOR 10 Years Later
title_short SEA and GATOR 10 Years Later
title_sort sea and gator 10 years later
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534245/
https://www.ncbi.nlm.nih.gov/pubmed/34685669
http://dx.doi.org/10.3390/cells10102689
work_keys_str_mv AT loissellbaltazaryahira seaandgator10yearslater
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