Emergence of the Novel Aminoglycoside Acetyltransferase Variant aac(6′)-Ib-D179Y and Acquisition of Colistin Heteroresistance in Carbapenem-Resistant Klebsiella pneumoniae Due to a Disrupting Mutation in the DNA Repair Enzyme MutS

Amikacin and colistin are effective against carbapenem-resistant Klebsiella pneumoniae. In 2017, we successively isolated three carbapenem-resistant K. pneumoniae isolates (ST967) from a patient with chronic renal failure in Japan. The first (SMKP01, sputum, day 0) and second (SMKP02, blood, day 14)...

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Detalles Bibliográficos
Autores principales: Sato, Toyotaka, Wada, Takayuki, Nishijima, Suguru, Fukushima, Yukari, Nakajima, Chie, Suzuki, Yasuhiko, Takahashi, Satoshi, Yokota, Shin-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534291/
https://www.ncbi.nlm.nih.gov/pubmed/33443109
http://dx.doi.org/10.1128/mBio.01954-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534291/
https://www.ncbi.nlm.nih.gov/pubmed/33443109
http://dx.doi.org/10.1128/mBio.01954-20

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