Adipose-Tissue-Derived Mesenchymal Stem Cells Mediate PD-L1 Overexpression in the White Adipose Tissue of Obese Individuals, Resulting in T Cell Dysfunction

The PD-L1/PD-1 immune checkpoint axis is the strongest T cell exhaustion inducer. As immune dysfunction occurs during obesity, we analyzed the impact of obesity on PD-L1/PD-1 expression in white adipose tissue (WAT) in mice and in human white adipocytes. We found that PD-L1 was overexpressed in WAT...

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Detalles Bibliográficos
Autores principales: Eljaafari, Assia, Pestel, Julien, Le Magueresse-Battistoni, Brigitte, Chanon, Stephanie, Watson, Julia, Robert, Maud, Disse, Emmanuel, Vidal, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534339/
https://www.ncbi.nlm.nih.gov/pubmed/34685625
http://dx.doi.org/10.3390/cells10102645

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