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Discovering the Molecular Landscape of Meningioma: The Struggle to Find New Therapeutic Targets
Meningiomas are the most common primary CNS tumors. They are usually benign but can present aggressive behavior in about 20% of cases. The genetic landscape of meningioma is characterized by the presence (in about 60% of cases) or absence of NF2 mutation. Low-grade meningiomas can also present other...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534341/ https://www.ncbi.nlm.nih.gov/pubmed/34679551 http://dx.doi.org/10.3390/diagnostics11101852 |
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author | Maggio, Ilaria Franceschi, Enrico Di Nunno, Vincenzo Gatto, Lidia Tosoni, Alicia Angelini, Daniele Bartolini, Stefania Lodi, Raffaele Brandes, Alba Ariela |
author_facet | Maggio, Ilaria Franceschi, Enrico Di Nunno, Vincenzo Gatto, Lidia Tosoni, Alicia Angelini, Daniele Bartolini, Stefania Lodi, Raffaele Brandes, Alba Ariela |
author_sort | Maggio, Ilaria |
collection | PubMed |
description | Meningiomas are the most common primary CNS tumors. They are usually benign but can present aggressive behavior in about 20% of cases. The genetic landscape of meningioma is characterized by the presence (in about 60% of cases) or absence of NF2 mutation. Low-grade meningiomas can also present other genetic alterations, particularly affecting SMO, TRAF7, KLF4 AKT1 and PI3KCA. In higher grade meningiomas, mutations of TERT promoter and deletion of CDKN2A/B seem to have a prognostic value. Furthermore, other genetic alterations have been identified, such as BAP1, DMD and PBRM1. Different subgroups of DNA methylation appear to be correlated with prognosis. In this review, we explored the genetic landscape of meningiomas and the possible therapeutic implications. |
format | Online Article Text |
id | pubmed-8534341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85343412021-10-23 Discovering the Molecular Landscape of Meningioma: The Struggle to Find New Therapeutic Targets Maggio, Ilaria Franceschi, Enrico Di Nunno, Vincenzo Gatto, Lidia Tosoni, Alicia Angelini, Daniele Bartolini, Stefania Lodi, Raffaele Brandes, Alba Ariela Diagnostics (Basel) Review Meningiomas are the most common primary CNS tumors. They are usually benign but can present aggressive behavior in about 20% of cases. The genetic landscape of meningioma is characterized by the presence (in about 60% of cases) or absence of NF2 mutation. Low-grade meningiomas can also present other genetic alterations, particularly affecting SMO, TRAF7, KLF4 AKT1 and PI3KCA. In higher grade meningiomas, mutations of TERT promoter and deletion of CDKN2A/B seem to have a prognostic value. Furthermore, other genetic alterations have been identified, such as BAP1, DMD and PBRM1. Different subgroups of DNA methylation appear to be correlated with prognosis. In this review, we explored the genetic landscape of meningiomas and the possible therapeutic implications. MDPI 2021-10-08 /pmc/articles/PMC8534341/ /pubmed/34679551 http://dx.doi.org/10.3390/diagnostics11101852 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Maggio, Ilaria Franceschi, Enrico Di Nunno, Vincenzo Gatto, Lidia Tosoni, Alicia Angelini, Daniele Bartolini, Stefania Lodi, Raffaele Brandes, Alba Ariela Discovering the Molecular Landscape of Meningioma: The Struggle to Find New Therapeutic Targets |
title | Discovering the Molecular Landscape of Meningioma: The Struggle to Find New Therapeutic Targets |
title_full | Discovering the Molecular Landscape of Meningioma: The Struggle to Find New Therapeutic Targets |
title_fullStr | Discovering the Molecular Landscape of Meningioma: The Struggle to Find New Therapeutic Targets |
title_full_unstemmed | Discovering the Molecular Landscape of Meningioma: The Struggle to Find New Therapeutic Targets |
title_short | Discovering the Molecular Landscape of Meningioma: The Struggle to Find New Therapeutic Targets |
title_sort | discovering the molecular landscape of meningioma: the struggle to find new therapeutic targets |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534341/ https://www.ncbi.nlm.nih.gov/pubmed/34679551 http://dx.doi.org/10.3390/diagnostics11101852 |
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