Cargando…

Neurogenic Potential of the 18-kDa Mitochondrial Translocator Protein (TSPO) in Pluripotent P19 Stem Cells

The 18-kDa translocator protein (TSPO) is a key mitochondrial target by which different TSPO ligands exert neuroprotective effects. We assayed the neurogenic potential of TSPO to induce the neuronal differentiation of pluripotent P19 stem cells in vitro. We studied changes in cell morphology, cell p...

Descripción completa

Detalles Bibliográficos
Autores principales:	González-Blanco, Laura, Bermejo-Millo, Juan Carlos, Oliveira, Gabriela, Potes, Yaiza, Antuña, Eduardo, Menéndez-Valle, Iván, Vega-Naredo, Ignacio, Coto-Montes, Ana, Caballero, Beatriz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534396/ https://www.ncbi.nlm.nih.gov/pubmed/34685764 http://dx.doi.org/10.3390/cells10102784

Ejemplares similares

The Interactome in the Evolution From Frailty to Sarcopenic Dependence
por: Coto-Montes, Ana, et al.
Publicado: (2021)

Inflammaging: Implications in Sarcopenia
por: Antuña, Eduardo, et al.
Publicado: (2022)

Benefits of the Neurogenic Potential of Melatonin for Treating Neurological and Neuropsychiatric Disorders
por: Potes, Yaiza, et al.
Publicado: (2023)

Cell interactome in sarcopenia during aging
por: González‐Blanco, Laura, et al.
Publicado: (2022)

18 kDa Translocator Protein TSPO Is a Mediator of Astrocyte Reactivity
por: Tournier, Benjamin B., et al.
Publicado: (2023)

Removal of Environmental Nanoparticles Increases Protein Synthesis and Energy Production in Healthy Humans
por: Antuña, Eduardo, et al.
Publicado: (2022)

Chronic Treatment with Melatonin Improves Hippocampal Neurogenesis in the Aged Brain and Under Neurodegeneration
por: Cachán-Vega, Cristina, et al.
Publicado: (2022)

Differential Cellular Interactome in Schizophrenia and Bipolar Disorder—Discriminatory Biomarker Role
por: Menéndez-Valle, Iván, et al.
Publicado: (2023)

Translocator Protein 18 kDa (TSPO) Is Regulated in White and Brown Adipose Tissue by Obesity
por: Thompson, Misty M., et al.
Publicado: (2013)

A Novel Interaction of Translocator Protein 18 kDa (TSPO) with NADPH Oxidase in Microglia
por: Loth, Meredith K., et al.
Publicado: (2020)

Translocator Protein 18 kDa (TSPO) as a Novel Therapeutic Target for Chronic Pain
por: Liu, Jie, et al.
Publicado: (2022)

Regulation of Translocator Protein 18 kDa (TSPO) Expression in Rat and Human Male Germ Cells
por: Manku, Gurpreet, et al.
Publicado: (2016)

Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function
por: Yao, Rumeng, et al.
Publicado: (2020)

In vitro and pilot in vivo imaging of 18 kDa translocator protein (TSPO) in inflammatory vascular disease
por: Schollhammer, Romain, et al.
Publicado: (2021)

SOD and CAT as potential preliminary biomarkers for the differential diagnosis of schizophrenia and bipolar disorder in the first episode of psychosis
por: Cachán-Vega, C., et al.
Publicado: (2023)

Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO)()
por: Colasanti, Alessandro, et al.
Publicado: (2013)

Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis
por: Karlstetter, Marcus, et al.
Publicado: (2014)

Characterization of the 18 kDa translocator protein (TSPO) expression in post‐mortem normal and Alzheimer's disease brains
por: Gui, Yaxing, et al.
Publicado: (2019)

Activated microglia do not increase 18 kDa translocator protein (TSPO) expression in the multiple sclerosis brain
por: Nutma, Erik, et al.
Publicado: (2021)

Melatonin Alleviates the Impairment of Muscle Bioenergetics and Protein Quality Control Systems in Leptin-Deficiency-Induced Obesity
por: Potes, Yaiza, et al.
Publicado: (2023)

An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28
por: Owen, David R, et al.
Publicado: (2012)

The 18-kDa Translocator Protein (TSPO) Disrupts Mammary Epithelial Morphogenesis and Promotes Breast Cancer Cell Migration
por: Wu, Xiaoting, et al.
Publicado: (2013)

Translocator protein 18 kDa (TSPO): old dogma, new mice, new structure, and new questions for neuroprotection
por: Kim, Eun-Jung, et al.
Publicado: (2015)

Current paradigm of the 18-kDa translocator protein (TSPO) as a molecular target for PET imaging in neuroinflammation and neurodegenerative diseases
por: Ching, Alex Sik Chung, et al.
Publicado: (2011)

Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration
por: Scholz, Rebecca, et al.
Publicado: (2015)

Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases
por: Dupont, Anne-Claire, et al.
Publicado: (2017)

Impact of Translocator Protein 18 kDa (TSPO) Deficiency on Mitochondrial Function and the Inflammatory State of Human C20 Microglia Cells
por: Bader, Stefanie, et al.
Publicado: (2023)

Translocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages
por: Weidner, Lorraine, et al.
Publicado: (2023)

In vivo evaluation of a novel (18)F-labeled PET radioligand for translocator protein 18 kDa (TSPO) in monkey brain
por: Yan, Xuefeng, et al.
Publicado: (2023)

Systematic Analysis of Translocator Protein 18 kDa (TSPO) Ligands on Toll-like Receptors-mediated Pro-inflammatory Responses in Microglia and Astrocytes
por: Lee, Ji-Won, et al.
Publicado: (2016)

Lentiviral-Mediated Overexpression of the 18 kDa Translocator Protein (TSPO) in the Hippocampal Dentate Gyrus Ameliorates LPS-Induced Cognitive Impairment in Mice
por: Wang, Wei, et al.
Publicado: (2016)

Overweight in the Elderly Induces a Switch in Energy Metabolism that Undermines Muscle Integrity
por: Potes, Yaiza, et al.
Publicado: (2019)

The 18 kDa Translocator Protein, Microglia and Neuroinflammation
por: Liu, Guo‐Jun, et al.
Publicado: (2014)

[(125) I]IodoDPA-713 Binding to 18 kDa Translocator Protein (TSPO) in a Mouse Model of Intracerebral Hemorrhage: Implications for Neuroimaging
por: Bonsack, Frederick, et al.
Publicado: (2018)

Imaging adipose tissue browning using the TSPO-18kDa tracer [(18)F]FEPPA
por: Hartimath, S.V., et al.
Publicado: (2019)

Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer’s disease
por: Pradhan, Arpit Kumar, et al.
Publicado: (2023)

The 18 kDa Translocator Protein (TSPO) Overexpression in Hippocampal Dentate Gyrus Elicits Anxiolytic-Like Effects in a Mouse Model of Post-traumatic Stress Disorder
por: Zhang, Xiao-Ying, et al.
Publicado: (2018)

The response to unfolded proteins in schizophrenia and bipolar disorder
por: Cachán, C., et al.
Publicado: (2023)

Synthesis and Evaluation of Translocator 18 kDa Protein (TSPO) Positron Emission Tomography (PET) Radioligands with Low Binding Sensitivity to Human Single Nucleotide Polymorphism rs6971
por: Zanotti-Fregonara, Paolo, et al.
Publicado: (2014)

PS30. Gender difference in stress responses as examined by TSPO (Translocator Protein 18 kDa), cortisol and STAI (State-Trait Anxiety Inventory) in normal human subjects.
por: Nakamoto, Yurie, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_mv8jcq2m1g010ifp3iqagm2pt6