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A Machine Learning Application to Predict Early Lung Involvement in Scleroderma: A Feasibility Evaluation

Introduction: Systemic sclerosis (SSc) is a systemic immune-mediated disease, featuring fibrosis of the skin and organs, and has the greatest mortality among rheumatic diseases. The nervous system involvement has recently been demonstrated, although actual lung involvement is considered the leading...

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Autores principales: Murdaca, Giuseppe, Caprioli, Simone, Tonacci, Alessandro, Billeci, Lucia, Greco, Monica, Negrini, Simone, Cittadini, Giuseppe, Zentilin, Patrizia, Ventura Spagnolo, Elvira, Gangemi, Sebastiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534403/
https://www.ncbi.nlm.nih.gov/pubmed/34679580
http://dx.doi.org/10.3390/diagnostics11101880
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author Murdaca, Giuseppe
Caprioli, Simone
Tonacci, Alessandro
Billeci, Lucia
Greco, Monica
Negrini, Simone
Cittadini, Giuseppe
Zentilin, Patrizia
Ventura Spagnolo, Elvira
Gangemi, Sebastiano
author_facet Murdaca, Giuseppe
Caprioli, Simone
Tonacci, Alessandro
Billeci, Lucia
Greco, Monica
Negrini, Simone
Cittadini, Giuseppe
Zentilin, Patrizia
Ventura Spagnolo, Elvira
Gangemi, Sebastiano
author_sort Murdaca, Giuseppe
collection PubMed
description Introduction: Systemic sclerosis (SSc) is a systemic immune-mediated disease, featuring fibrosis of the skin and organs, and has the greatest mortality among rheumatic diseases. The nervous system involvement has recently been demonstrated, although actual lung involvement is considered the leading cause of death in SSc and, therefore, should be diagnosed early. Pulmonary function tests are not sensitive enough to be used for screening purposes, thus they should be flanked by other clinical examinations; however, this would lead to a risk of overtesting, with considerable costs for the health system and an unnecessary burden for the patients. To this extent, Machine Learning (ML) algorithms could represent a useful add-on to the current clinical practice for diagnostic purposes and could help retrieve the most useful exams to be carried out for diagnostic purposes. Method: Here, we retrospectively collected high resolution computed tomography, pulmonary function tests, esophageal pH impedance tests, esophageal manometry and reflux disease questionnaires of 38 patients with SSc, applying, with R, different supervised ML algorithms, including lasso, ridge, elastic net, classification and regression trees (CART) and random forest to estimate the most important predictors for pulmonary involvement from such data. Results: In terms of performance, the random forest algorithm outperformed the other classifiers, with an estimated root-mean-square error (RMSE) of 0.810. However, this algorithm was seen to be computationally intensive, leaving room for the usefulness of other classifiers when a shorter response time is needed. Conclusions: Despite the notably small sample size, that could have prevented obtaining fully reliable data, the powerful tools available for ML can be useful for predicting early lung involvement in SSc patients. The use of predictors coming from spirometry and pH impedentiometry together might perform optimally for predicting early lung involvement in SSc.
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spelling pubmed-85344032021-10-23 A Machine Learning Application to Predict Early Lung Involvement in Scleroderma: A Feasibility Evaluation Murdaca, Giuseppe Caprioli, Simone Tonacci, Alessandro Billeci, Lucia Greco, Monica Negrini, Simone Cittadini, Giuseppe Zentilin, Patrizia Ventura Spagnolo, Elvira Gangemi, Sebastiano Diagnostics (Basel) Article Introduction: Systemic sclerosis (SSc) is a systemic immune-mediated disease, featuring fibrosis of the skin and organs, and has the greatest mortality among rheumatic diseases. The nervous system involvement has recently been demonstrated, although actual lung involvement is considered the leading cause of death in SSc and, therefore, should be diagnosed early. Pulmonary function tests are not sensitive enough to be used for screening purposes, thus they should be flanked by other clinical examinations; however, this would lead to a risk of overtesting, with considerable costs for the health system and an unnecessary burden for the patients. To this extent, Machine Learning (ML) algorithms could represent a useful add-on to the current clinical practice for diagnostic purposes and could help retrieve the most useful exams to be carried out for diagnostic purposes. Method: Here, we retrospectively collected high resolution computed tomography, pulmonary function tests, esophageal pH impedance tests, esophageal manometry and reflux disease questionnaires of 38 patients with SSc, applying, with R, different supervised ML algorithms, including lasso, ridge, elastic net, classification and regression trees (CART) and random forest to estimate the most important predictors for pulmonary involvement from such data. Results: In terms of performance, the random forest algorithm outperformed the other classifiers, with an estimated root-mean-square error (RMSE) of 0.810. However, this algorithm was seen to be computationally intensive, leaving room for the usefulness of other classifiers when a shorter response time is needed. Conclusions: Despite the notably small sample size, that could have prevented obtaining fully reliable data, the powerful tools available for ML can be useful for predicting early lung involvement in SSc patients. The use of predictors coming from spirometry and pH impedentiometry together might perform optimally for predicting early lung involvement in SSc. MDPI 2021-10-12 /pmc/articles/PMC8534403/ /pubmed/34679580 http://dx.doi.org/10.3390/diagnostics11101880 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Murdaca, Giuseppe
Caprioli, Simone
Tonacci, Alessandro
Billeci, Lucia
Greco, Monica
Negrini, Simone
Cittadini, Giuseppe
Zentilin, Patrizia
Ventura Spagnolo, Elvira
Gangemi, Sebastiano
A Machine Learning Application to Predict Early Lung Involvement in Scleroderma: A Feasibility Evaluation
title A Machine Learning Application to Predict Early Lung Involvement in Scleroderma: A Feasibility Evaluation
title_full A Machine Learning Application to Predict Early Lung Involvement in Scleroderma: A Feasibility Evaluation
title_fullStr A Machine Learning Application to Predict Early Lung Involvement in Scleroderma: A Feasibility Evaluation
title_full_unstemmed A Machine Learning Application to Predict Early Lung Involvement in Scleroderma: A Feasibility Evaluation
title_short A Machine Learning Application to Predict Early Lung Involvement in Scleroderma: A Feasibility Evaluation
title_sort machine learning application to predict early lung involvement in scleroderma: a feasibility evaluation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534403/
https://www.ncbi.nlm.nih.gov/pubmed/34679580
http://dx.doi.org/10.3390/diagnostics11101880
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