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Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature

Pediatric optic neuritis (PON) may be a clinically isolated and self-limiting event or may present in the context of underlying neurologic, infective, or systemic disease. PON has a high impact on the quality of life as it may or may not evolve into other acquired demyelinating syndromes (ADSs), suc...

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Autores principales: Presicci, Anna, Serra, Maria, Achille, Mariaclara, Caputo, Elvita, Margari, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534428/
https://www.ncbi.nlm.nih.gov/pubmed/34682120
http://dx.doi.org/10.3390/children8100855
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author Presicci, Anna
Serra, Maria
Achille, Mariaclara
Caputo, Elvita
Margari, Lucia
author_facet Presicci, Anna
Serra, Maria
Achille, Mariaclara
Caputo, Elvita
Margari, Lucia
author_sort Presicci, Anna
collection PubMed
description Pediatric optic neuritis (PON) may be a clinically isolated and self-limiting event or may present in the context of underlying neurologic, infective, or systemic disease. PON has a high impact on the quality of life as it may or may not evolve into other acquired demyelinating syndromes (ADSs), such as multiple sclerosis (MS), neuromyelitis optica (NMO), or other syndromes related to the myelin oligodendrocyte glycoprotein IgG antibodies (MOG-IgG). These different PON phenotypes present variable clinical and radiological features, plasma and liquor biomarkers, and prognosis. We describe four pediatric cases presenting clinically with ON, with different etiopathogenetic pictures: one case had a probable infective etiology, while the others were associated with different demyelinating disorders (MS, NMO, syndrome related to MOG-IgG). We discuss the possible evolution of presenting ON in other ADSs, based on recent literature. A careful evaluation of the clinical and investigation findings and the natural course of PON is necessary to define its pathogenic pathway and evolution. Further prolonged follow-up studies are needed to highlight the predictors of PON evolution, its potential sequelae, and the best treatment options.
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spelling pubmed-85344282021-10-23 Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature Presicci, Anna Serra, Maria Achille, Mariaclara Caputo, Elvita Margari, Lucia Children (Basel) Case Report Pediatric optic neuritis (PON) may be a clinically isolated and self-limiting event or may present in the context of underlying neurologic, infective, or systemic disease. PON has a high impact on the quality of life as it may or may not evolve into other acquired demyelinating syndromes (ADSs), such as multiple sclerosis (MS), neuromyelitis optica (NMO), or other syndromes related to the myelin oligodendrocyte glycoprotein IgG antibodies (MOG-IgG). These different PON phenotypes present variable clinical and radiological features, plasma and liquor biomarkers, and prognosis. We describe four pediatric cases presenting clinically with ON, with different etiopathogenetic pictures: one case had a probable infective etiology, while the others were associated with different demyelinating disorders (MS, NMO, syndrome related to MOG-IgG). We discuss the possible evolution of presenting ON in other ADSs, based on recent literature. A careful evaluation of the clinical and investigation findings and the natural course of PON is necessary to define its pathogenic pathway and evolution. Further prolonged follow-up studies are needed to highlight the predictors of PON evolution, its potential sequelae, and the best treatment options. MDPI 2021-09-27 /pmc/articles/PMC8534428/ /pubmed/34682120 http://dx.doi.org/10.3390/children8100855 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Presicci, Anna
Serra, Maria
Achille, Mariaclara
Caputo, Elvita
Margari, Lucia
Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature
title Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature
title_full Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature
title_fullStr Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature
title_full_unstemmed Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature
title_short Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature
title_sort pediatric optic neuritis: description of four cases and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534428/
https://www.ncbi.nlm.nih.gov/pubmed/34682120
http://dx.doi.org/10.3390/children8100855
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