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Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature
Pediatric optic neuritis (PON) may be a clinically isolated and self-limiting event or may present in the context of underlying neurologic, infective, or systemic disease. PON has a high impact on the quality of life as it may or may not evolve into other acquired demyelinating syndromes (ADSs), suc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534428/ https://www.ncbi.nlm.nih.gov/pubmed/34682120 http://dx.doi.org/10.3390/children8100855 |
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author | Presicci, Anna Serra, Maria Achille, Mariaclara Caputo, Elvita Margari, Lucia |
author_facet | Presicci, Anna Serra, Maria Achille, Mariaclara Caputo, Elvita Margari, Lucia |
author_sort | Presicci, Anna |
collection | PubMed |
description | Pediatric optic neuritis (PON) may be a clinically isolated and self-limiting event or may present in the context of underlying neurologic, infective, or systemic disease. PON has a high impact on the quality of life as it may or may not evolve into other acquired demyelinating syndromes (ADSs), such as multiple sclerosis (MS), neuromyelitis optica (NMO), or other syndromes related to the myelin oligodendrocyte glycoprotein IgG antibodies (MOG-IgG). These different PON phenotypes present variable clinical and radiological features, plasma and liquor biomarkers, and prognosis. We describe four pediatric cases presenting clinically with ON, with different etiopathogenetic pictures: one case had a probable infective etiology, while the others were associated with different demyelinating disorders (MS, NMO, syndrome related to MOG-IgG). We discuss the possible evolution of presenting ON in other ADSs, based on recent literature. A careful evaluation of the clinical and investigation findings and the natural course of PON is necessary to define its pathogenic pathway and evolution. Further prolonged follow-up studies are needed to highlight the predictors of PON evolution, its potential sequelae, and the best treatment options. |
format | Online Article Text |
id | pubmed-8534428 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85344282021-10-23 Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature Presicci, Anna Serra, Maria Achille, Mariaclara Caputo, Elvita Margari, Lucia Children (Basel) Case Report Pediatric optic neuritis (PON) may be a clinically isolated and self-limiting event or may present in the context of underlying neurologic, infective, or systemic disease. PON has a high impact on the quality of life as it may or may not evolve into other acquired demyelinating syndromes (ADSs), such as multiple sclerosis (MS), neuromyelitis optica (NMO), or other syndromes related to the myelin oligodendrocyte glycoprotein IgG antibodies (MOG-IgG). These different PON phenotypes present variable clinical and radiological features, plasma and liquor biomarkers, and prognosis. We describe four pediatric cases presenting clinically with ON, with different etiopathogenetic pictures: one case had a probable infective etiology, while the others were associated with different demyelinating disorders (MS, NMO, syndrome related to MOG-IgG). We discuss the possible evolution of presenting ON in other ADSs, based on recent literature. A careful evaluation of the clinical and investigation findings and the natural course of PON is necessary to define its pathogenic pathway and evolution. Further prolonged follow-up studies are needed to highlight the predictors of PON evolution, its potential sequelae, and the best treatment options. MDPI 2021-09-27 /pmc/articles/PMC8534428/ /pubmed/34682120 http://dx.doi.org/10.3390/children8100855 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Presicci, Anna Serra, Maria Achille, Mariaclara Caputo, Elvita Margari, Lucia Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature |
title | Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature |
title_full | Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature |
title_fullStr | Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature |
title_full_unstemmed | Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature |
title_short | Pediatric Optic Neuritis: Description of Four Cases and Review of the Literature |
title_sort | pediatric optic neuritis: description of four cases and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534428/ https://www.ncbi.nlm.nih.gov/pubmed/34682120 http://dx.doi.org/10.3390/children8100855 |
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