Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span

Certain plant extracts (PEs) contain bioactive compounds that have antioxidant and lifespan-extending activities on organisms. These PEs play different roles in cellular processes, such as enhancing stress resistance and modulating longevity-defined signaling pathways that contribute to longevity. H...

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Autores principales: Kwong, Mandy Mun Yee, Lee, Jee Whu, Samian, Mohammed Razip, Wahab, Habibah A., Watanabe, Nobumoto, Ong, Eugene Boon Beng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534465/
https://www.ncbi.nlm.nih.gov/pubmed/34685698
http://dx.doi.org/10.3390/cells10102718
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author Kwong, Mandy Mun Yee
Lee, Jee Whu
Samian, Mohammed Razip
Wahab, Habibah A.
Watanabe, Nobumoto
Ong, Eugene Boon Beng
author_facet Kwong, Mandy Mun Yee
Lee, Jee Whu
Samian, Mohammed Razip
Wahab, Habibah A.
Watanabe, Nobumoto
Ong, Eugene Boon Beng
author_sort Kwong, Mandy Mun Yee
collection PubMed
description Certain plant extracts (PEs) contain bioactive compounds that have antioxidant and lifespan-extending activities on organisms. These PEs play different roles in cellular processes, such as enhancing stress resistance and modulating longevity-defined signaling pathways that contribute to longevity. Here, we report the discovery of PEs that extended chronological life span (CLS) in budding yeast from a screen of 222 PEs. We identified two PEs, the leaf extracts of Manihot esculenta and Wodyetia bifurcata that extended CLS in a dose-dependent manner. The CLS-extending PEs also conferred oxidative stress tolerance, suggesting that these PEs might extend yeast CLS through the upregulation of stress response pathways.
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spelling pubmed-85344652021-10-23 Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span Kwong, Mandy Mun Yee Lee, Jee Whu Samian, Mohammed Razip Wahab, Habibah A. Watanabe, Nobumoto Ong, Eugene Boon Beng Cells Article Certain plant extracts (PEs) contain bioactive compounds that have antioxidant and lifespan-extending activities on organisms. These PEs play different roles in cellular processes, such as enhancing stress resistance and modulating longevity-defined signaling pathways that contribute to longevity. Here, we report the discovery of PEs that extended chronological life span (CLS) in budding yeast from a screen of 222 PEs. We identified two PEs, the leaf extracts of Manihot esculenta and Wodyetia bifurcata that extended CLS in a dose-dependent manner. The CLS-extending PEs also conferred oxidative stress tolerance, suggesting that these PEs might extend yeast CLS through the upregulation of stress response pathways. MDPI 2021-10-11 /pmc/articles/PMC8534465/ /pubmed/34685698 http://dx.doi.org/10.3390/cells10102718 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kwong, Mandy Mun Yee
Lee, Jee Whu
Samian, Mohammed Razip
Wahab, Habibah A.
Watanabe, Nobumoto
Ong, Eugene Boon Beng
Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span
title Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span
title_full Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span
title_fullStr Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span
title_full_unstemmed Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span
title_short Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span
title_sort identification of tropical plant extracts that extend yeast chronological life span
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534465/
https://www.ncbi.nlm.nih.gov/pubmed/34685698
http://dx.doi.org/10.3390/cells10102718
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