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Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease
Neopterin (NPT), a pyrazino-pyrimidine compound mainly produced by activated macrophages, has been regarded as a proinflammatory and proatherosclerotic agent. The study was designed to evaluate NPT level and its interaction with conventional peripheral artery disease (PAD) biomarkers and vascular re...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534562/ https://www.ncbi.nlm.nih.gov/pubmed/34679610 http://dx.doi.org/10.3390/diagnostics11101911 |
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author | Zembron-Lacny, Agnieszka Dziubek, Wioletta Tylutka, Anna Wacka, Eryk Morawin, Barbara Bulinska, Katarzyna Stefanska, Malgorzata Wozniewski, Marek Szuba, Andrzej |
author_facet | Zembron-Lacny, Agnieszka Dziubek, Wioletta Tylutka, Anna Wacka, Eryk Morawin, Barbara Bulinska, Katarzyna Stefanska, Malgorzata Wozniewski, Marek Szuba, Andrzej |
author_sort | Zembron-Lacny, Agnieszka |
collection | PubMed |
description | Neopterin (NPT), a pyrazino-pyrimidine compound mainly produced by activated macrophages, has been regarded as a proinflammatory and proatherosclerotic agent. The study was designed to evaluate NPT level and its interaction with conventional peripheral artery disease (PAD) biomarkers and vascular regenerative potential in severe PAD. The study included 59 patients (females n = 17, males n = 42) aged 67.0 ± 8.2 years classified into two groups based on ankle-brachial index (ABI) measurements (ABI ≤ 0.9 n = 43, ABI ≤ 0.5 n = 16). A total of 60 subjects aged 70.4 ± 5.5 years (females n = 42, males n = 18) with ABI > 0.9 constituted a reference group. NPT concentration reached values above 10 nmol/L in patients with PAD, which differed significantly from reference group (8.15 ± 1.33 nmol/L). High levels of CRP > 5 mg/L, TC > 200 mg/dL as well as lipoproteins LDL > 100 mg/dL and non-HDL > 130 mg/dL were found in the same group, indicating the relationship between NPT and conventional atherogenic markers. The endothelial progenitor cells (EPCs) tended toward lower values in patients with ABI ≤ 0.5 when compared to reference group, and inversely correlated with NPT. These findings indicate a crucial role of NPT in atheromatous process and its usefulness in monitoring PAD severity. However, the role of NPT in chronic PAD needs further studies including relatively high number of subjects. |
format | Online Article Text |
id | pubmed-8534562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85345622021-10-23 Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease Zembron-Lacny, Agnieszka Dziubek, Wioletta Tylutka, Anna Wacka, Eryk Morawin, Barbara Bulinska, Katarzyna Stefanska, Malgorzata Wozniewski, Marek Szuba, Andrzej Diagnostics (Basel) Article Neopterin (NPT), a pyrazino-pyrimidine compound mainly produced by activated macrophages, has been regarded as a proinflammatory and proatherosclerotic agent. The study was designed to evaluate NPT level and its interaction with conventional peripheral artery disease (PAD) biomarkers and vascular regenerative potential in severe PAD. The study included 59 patients (females n = 17, males n = 42) aged 67.0 ± 8.2 years classified into two groups based on ankle-brachial index (ABI) measurements (ABI ≤ 0.9 n = 43, ABI ≤ 0.5 n = 16). A total of 60 subjects aged 70.4 ± 5.5 years (females n = 42, males n = 18) with ABI > 0.9 constituted a reference group. NPT concentration reached values above 10 nmol/L in patients with PAD, which differed significantly from reference group (8.15 ± 1.33 nmol/L). High levels of CRP > 5 mg/L, TC > 200 mg/dL as well as lipoproteins LDL > 100 mg/dL and non-HDL > 130 mg/dL were found in the same group, indicating the relationship between NPT and conventional atherogenic markers. The endothelial progenitor cells (EPCs) tended toward lower values in patients with ABI ≤ 0.5 when compared to reference group, and inversely correlated with NPT. These findings indicate a crucial role of NPT in atheromatous process and its usefulness in monitoring PAD severity. However, the role of NPT in chronic PAD needs further studies including relatively high number of subjects. MDPI 2021-10-15 /pmc/articles/PMC8534562/ /pubmed/34679610 http://dx.doi.org/10.3390/diagnostics11101911 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zembron-Lacny, Agnieszka Dziubek, Wioletta Tylutka, Anna Wacka, Eryk Morawin, Barbara Bulinska, Katarzyna Stefanska, Malgorzata Wozniewski, Marek Szuba, Andrzej Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease |
title | Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease |
title_full | Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease |
title_fullStr | Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease |
title_full_unstemmed | Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease |
title_short | Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease |
title_sort | assessment of serum neopterin as a biomarker in peripheral artery disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534562/ https://www.ncbi.nlm.nih.gov/pubmed/34679610 http://dx.doi.org/10.3390/diagnostics11101911 |
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