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Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease

Neopterin (NPT), a pyrazino-pyrimidine compound mainly produced by activated macrophages, has been regarded as a proinflammatory and proatherosclerotic agent. The study was designed to evaluate NPT level and its interaction with conventional peripheral artery disease (PAD) biomarkers and vascular re...

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Autores principales: Zembron-Lacny, Agnieszka, Dziubek, Wioletta, Tylutka, Anna, Wacka, Eryk, Morawin, Barbara, Bulinska, Katarzyna, Stefanska, Malgorzata, Wozniewski, Marek, Szuba, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534562/
https://www.ncbi.nlm.nih.gov/pubmed/34679610
http://dx.doi.org/10.3390/diagnostics11101911
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author Zembron-Lacny, Agnieszka
Dziubek, Wioletta
Tylutka, Anna
Wacka, Eryk
Morawin, Barbara
Bulinska, Katarzyna
Stefanska, Malgorzata
Wozniewski, Marek
Szuba, Andrzej
author_facet Zembron-Lacny, Agnieszka
Dziubek, Wioletta
Tylutka, Anna
Wacka, Eryk
Morawin, Barbara
Bulinska, Katarzyna
Stefanska, Malgorzata
Wozniewski, Marek
Szuba, Andrzej
author_sort Zembron-Lacny, Agnieszka
collection PubMed
description Neopterin (NPT), a pyrazino-pyrimidine compound mainly produced by activated macrophages, has been regarded as a proinflammatory and proatherosclerotic agent. The study was designed to evaluate NPT level and its interaction with conventional peripheral artery disease (PAD) biomarkers and vascular regenerative potential in severe PAD. The study included 59 patients (females n = 17, males n = 42) aged 67.0 ± 8.2 years classified into two groups based on ankle-brachial index (ABI) measurements (ABI ≤ 0.9 n = 43, ABI ≤ 0.5 n = 16). A total of 60 subjects aged 70.4 ± 5.5 years (females n = 42, males n = 18) with ABI > 0.9 constituted a reference group. NPT concentration reached values above 10 nmol/L in patients with PAD, which differed significantly from reference group (8.15 ± 1.33 nmol/L). High levels of CRP > 5 mg/L, TC > 200 mg/dL as well as lipoproteins LDL > 100 mg/dL and non-HDL > 130 mg/dL were found in the same group, indicating the relationship between NPT and conventional atherogenic markers. The endothelial progenitor cells (EPCs) tended toward lower values in patients with ABI ≤ 0.5 when compared to reference group, and inversely correlated with NPT. These findings indicate a crucial role of NPT in atheromatous process and its usefulness in monitoring PAD severity. However, the role of NPT in chronic PAD needs further studies including relatively high number of subjects.
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spelling pubmed-85345622021-10-23 Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease Zembron-Lacny, Agnieszka Dziubek, Wioletta Tylutka, Anna Wacka, Eryk Morawin, Barbara Bulinska, Katarzyna Stefanska, Malgorzata Wozniewski, Marek Szuba, Andrzej Diagnostics (Basel) Article Neopterin (NPT), a pyrazino-pyrimidine compound mainly produced by activated macrophages, has been regarded as a proinflammatory and proatherosclerotic agent. The study was designed to evaluate NPT level and its interaction with conventional peripheral artery disease (PAD) biomarkers and vascular regenerative potential in severe PAD. The study included 59 patients (females n = 17, males n = 42) aged 67.0 ± 8.2 years classified into two groups based on ankle-brachial index (ABI) measurements (ABI ≤ 0.9 n = 43, ABI ≤ 0.5 n = 16). A total of 60 subjects aged 70.4 ± 5.5 years (females n = 42, males n = 18) with ABI > 0.9 constituted a reference group. NPT concentration reached values above 10 nmol/L in patients with PAD, which differed significantly from reference group (8.15 ± 1.33 nmol/L). High levels of CRP > 5 mg/L, TC > 200 mg/dL as well as lipoproteins LDL > 100 mg/dL and non-HDL > 130 mg/dL were found in the same group, indicating the relationship between NPT and conventional atherogenic markers. The endothelial progenitor cells (EPCs) tended toward lower values in patients with ABI ≤ 0.5 when compared to reference group, and inversely correlated with NPT. These findings indicate a crucial role of NPT in atheromatous process and its usefulness in monitoring PAD severity. However, the role of NPT in chronic PAD needs further studies including relatively high number of subjects. MDPI 2021-10-15 /pmc/articles/PMC8534562/ /pubmed/34679610 http://dx.doi.org/10.3390/diagnostics11101911 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zembron-Lacny, Agnieszka
Dziubek, Wioletta
Tylutka, Anna
Wacka, Eryk
Morawin, Barbara
Bulinska, Katarzyna
Stefanska, Malgorzata
Wozniewski, Marek
Szuba, Andrzej
Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease
title Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease
title_full Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease
title_fullStr Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease
title_full_unstemmed Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease
title_short Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease
title_sort assessment of serum neopterin as a biomarker in peripheral artery disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534562/
https://www.ncbi.nlm.nih.gov/pubmed/34679610
http://dx.doi.org/10.3390/diagnostics11101911
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