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Role of Extracellular Vesicles in Cell Death and Inflammation
Extracellular vesicles (EVs) have been identified as novel mediators of intercellular communication. They work via delivering the sequestered cargo to cells in the close vicinity, as well as distant sites in the body, regulating pathophysiological processes. Cell death and inflammation are biologica...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534608/ https://www.ncbi.nlm.nih.gov/pubmed/34685643 http://dx.doi.org/10.3390/cells10102663 |
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author | Sanwlani, Rahul Gangoda, Lahiru |
author_facet | Sanwlani, Rahul Gangoda, Lahiru |
author_sort | Sanwlani, Rahul |
collection | PubMed |
description | Extracellular vesicles (EVs) have been identified as novel mediators of intercellular communication. They work via delivering the sequestered cargo to cells in the close vicinity, as well as distant sites in the body, regulating pathophysiological processes. Cell death and inflammation are biologically crucial processes in both normal physiology and pathology. These processes are indistinguishably linked with their effectors modulating the other process. For instance, during an unresolvable infection, the upregulation of specific immune mediators leads to inflammation causing cell death and tissue damage. EVs have gained considerable interest as mediators of both cell death and inflammation during conditions, such as sepsis. This review summarizes the types of extracellular vesicles known to date and their roles in mediating immune responses leading to cell death and inflammation with specific focus on sepsis and lung inflammation. |
format | Online Article Text |
id | pubmed-8534608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85346082021-10-23 Role of Extracellular Vesicles in Cell Death and Inflammation Sanwlani, Rahul Gangoda, Lahiru Cells Review Extracellular vesicles (EVs) have been identified as novel mediators of intercellular communication. They work via delivering the sequestered cargo to cells in the close vicinity, as well as distant sites in the body, regulating pathophysiological processes. Cell death and inflammation are biologically crucial processes in both normal physiology and pathology. These processes are indistinguishably linked with their effectors modulating the other process. For instance, during an unresolvable infection, the upregulation of specific immune mediators leads to inflammation causing cell death and tissue damage. EVs have gained considerable interest as mediators of both cell death and inflammation during conditions, such as sepsis. This review summarizes the types of extracellular vesicles known to date and their roles in mediating immune responses leading to cell death and inflammation with specific focus on sepsis and lung inflammation. MDPI 2021-10-05 /pmc/articles/PMC8534608/ /pubmed/34685643 http://dx.doi.org/10.3390/cells10102663 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sanwlani, Rahul Gangoda, Lahiru Role of Extracellular Vesicles in Cell Death and Inflammation |
title | Role of Extracellular Vesicles in Cell Death and Inflammation |
title_full | Role of Extracellular Vesicles in Cell Death and Inflammation |
title_fullStr | Role of Extracellular Vesicles in Cell Death and Inflammation |
title_full_unstemmed | Role of Extracellular Vesicles in Cell Death and Inflammation |
title_short | Role of Extracellular Vesicles in Cell Death and Inflammation |
title_sort | role of extracellular vesicles in cell death and inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534608/ https://www.ncbi.nlm.nih.gov/pubmed/34685643 http://dx.doi.org/10.3390/cells10102663 |
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