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Comprehensive Genomic Profiling of Circulating Cell-Free DNA Distinguishes Focal MET Amplification from Aneuploidy in Diverse Advanced Cancers

Amplification (amp) of MET can be observed in cases of focal gene copy number gain, such as MET-driven amp, or with a gain of chromosome 7, such as aneuploidy. Several studies have shown that only high-level focal MET amp (MET/CEP7 ratio ≥5) is oncogenic, with such tumors responding to targeted ther...

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Detalles Bibliográficos
Autores principales:	Kumaki, Yuichi, Olsen, Steve, Suenaga, Mitsukuni, Nakagawa, Tsuyoshi, Uetake, Hiroyuki, Ikeda, Sadakatsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534719/ https://www.ncbi.nlm.nih.gov/pubmed/34677235 http://dx.doi.org/10.3390/curroncol28050317

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