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Computational Fluid Dynamic Technique for Assessment of How Changing Character of Blood Flow and Different Value of Hct Influence Blood Hemodynamic in Dissected Aorta

Using computer tomography angiography (CTA) and computational structural analysis, we present a non-invasive method of mass flow rate/velocity and wall stress analysis in type B aortic dissection. Three-dimensional (3D) computer models of the aorta were calculated using pre-operative (baseline) and...

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Autores principales: Polanczyk, Andrzej, Piechota-Polanczyk, Aleksandra, Huk, Ihor, Neumayer, Christoph, Balcer, Julia, Strzelecki, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534802/
https://www.ncbi.nlm.nih.gov/pubmed/34679564
http://dx.doi.org/10.3390/diagnostics11101866
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author Polanczyk, Andrzej
Piechota-Polanczyk, Aleksandra
Huk, Ihor
Neumayer, Christoph
Balcer, Julia
Strzelecki, Michal
author_facet Polanczyk, Andrzej
Piechota-Polanczyk, Aleksandra
Huk, Ihor
Neumayer, Christoph
Balcer, Julia
Strzelecki, Michal
author_sort Polanczyk, Andrzej
collection PubMed
description Using computer tomography angiography (CTA) and computational structural analysis, we present a non-invasive method of mass flow rate/velocity and wall stress analysis in type B aortic dissection. Three-dimensional (3D) computer models of the aorta were calculated using pre-operative (baseline) and post-operative CT data from 12 male patients (aged from 51 to 64 years) who were treated for acute type B dissection. A computational fluid dynamics (CFD) technique was used to quantify the displacement forces acting on the aortic wall in the areas of endografts placement. The mass flow rate and wall stress were measured and quantified using the CFD technique. The CFD model indicated the places with a lower value of blood velocity and shear rate, which corelated with higher blood viscosity and a probability of thrombus appearance. Moreover, with the increase in Hct, blood viscosity also increased, while the intensity of blood flow provoked changing viscosity values in these areas. Furthermore, the velocity gradient near the tear surface caused high wall WSS; this could lead to a decreased resistance in the aorta’s wall with further implications to a patient.
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spelling pubmed-85348022021-10-23 Computational Fluid Dynamic Technique for Assessment of How Changing Character of Blood Flow and Different Value of Hct Influence Blood Hemodynamic in Dissected Aorta Polanczyk, Andrzej Piechota-Polanczyk, Aleksandra Huk, Ihor Neumayer, Christoph Balcer, Julia Strzelecki, Michal Diagnostics (Basel) Article Using computer tomography angiography (CTA) and computational structural analysis, we present a non-invasive method of mass flow rate/velocity and wall stress analysis in type B aortic dissection. Three-dimensional (3D) computer models of the aorta were calculated using pre-operative (baseline) and post-operative CT data from 12 male patients (aged from 51 to 64 years) who were treated for acute type B dissection. A computational fluid dynamics (CFD) technique was used to quantify the displacement forces acting on the aortic wall in the areas of endografts placement. The mass flow rate and wall stress were measured and quantified using the CFD technique. The CFD model indicated the places with a lower value of blood velocity and shear rate, which corelated with higher blood viscosity and a probability of thrombus appearance. Moreover, with the increase in Hct, blood viscosity also increased, while the intensity of blood flow provoked changing viscosity values in these areas. Furthermore, the velocity gradient near the tear surface caused high wall WSS; this could lead to a decreased resistance in the aorta’s wall with further implications to a patient. MDPI 2021-10-11 /pmc/articles/PMC8534802/ /pubmed/34679564 http://dx.doi.org/10.3390/diagnostics11101866 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Polanczyk, Andrzej
Piechota-Polanczyk, Aleksandra
Huk, Ihor
Neumayer, Christoph
Balcer, Julia
Strzelecki, Michal
Computational Fluid Dynamic Technique for Assessment of How Changing Character of Blood Flow and Different Value of Hct Influence Blood Hemodynamic in Dissected Aorta
title Computational Fluid Dynamic Technique for Assessment of How Changing Character of Blood Flow and Different Value of Hct Influence Blood Hemodynamic in Dissected Aorta
title_full Computational Fluid Dynamic Technique for Assessment of How Changing Character of Blood Flow and Different Value of Hct Influence Blood Hemodynamic in Dissected Aorta
title_fullStr Computational Fluid Dynamic Technique for Assessment of How Changing Character of Blood Flow and Different Value of Hct Influence Blood Hemodynamic in Dissected Aorta
title_full_unstemmed Computational Fluid Dynamic Technique for Assessment of How Changing Character of Blood Flow and Different Value of Hct Influence Blood Hemodynamic in Dissected Aorta
title_short Computational Fluid Dynamic Technique for Assessment of How Changing Character of Blood Flow and Different Value of Hct Influence Blood Hemodynamic in Dissected Aorta
title_sort computational fluid dynamic technique for assessment of how changing character of blood flow and different value of hct influence blood hemodynamic in dissected aorta
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8534802/
https://www.ncbi.nlm.nih.gov/pubmed/34679564
http://dx.doi.org/10.3390/diagnostics11101866
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